After doing a little research I found that this molecule lacks antihistaminergic effects, and is an effective anxiolytic at doses of 150mg, also lacks the sedative effects of benzodiazepines.
Any ideas as to what receptors it targets?
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N&PD Moderators: Skorpio
Captodiamine - mechanism of action?
- Thread starter wungchow
- Start date
After doing a little research I found that this molecule lacks antihistaminergic effects, and is an effective anxiolytic at doses of 150mg, also lacks the sedative effects of benzodiazepines.
Any ideas as to what receptors it targets? 
Jamshyd
Bluelight Crew
I'm guessing it is "anxiolytic" the same way Hydroxyzine is "anxiolytic". I believe there is an old captodiamine thread in this forum already. Do a search.
Riemann Zeta
Bluelighter
It certainly looks like it would have antihistaminergic and antimuscarinic effects. If it looks, smells like, walks like, talks like...an antihistamine, it probably is.Diphenhydramine inhibits reuptake of serotonin, is it probable that this substance does as well?
Except for this article, http://www.medscape.com/viewarticle/489359 , I have not been able to find any digitalised material on captodiame/captodiamine. According to a title (this one, http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum ) captodiamine potentiates hexobarbitol, perhaps someone has access to it?MurphyClox
Bluelighter
- Joined
- Mar 26, 2008
- Messages
- 1,416
Oh yeah, the structural similarity to modafinil is indeed astonishing.
Captodiamine is known to potentiate the action of barbiturates, thiobarbiturates, ketobemidone, pethidine, isomethadone, and morphine, most probably by inhibition of metabolising enzymes (CYP-family).
To my best knowledge, the exact molecular pharmacology (targeted receptor(s)) is not known, as captodiamine was abandoned some time ago and oviously nobody sees the need for new investigations.
Murphy
