Cannabis users 'suffering new syndrome'

hoptis

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Cannabis users 'suffering new syndrome'
By Danny Rose

AAP
March 23, 2009 05:47pm

THERE is mounting evidence to support the existence of a new syndrome afflicting heavy cannabis users, after the world's first cases were found in South Australia.

The condition "cannabinoid hyperemesis" was first identified in a group of about 20 heavy drug users in the Adelaide hills in 2004, and a new case has emerged this time in the US.

The syndrome is characterised by nausea, stomach pain and bouts of vomiting - ill effects which, oddly, sufferers say they get some relief from by h a ving a hot shower or bath.

The new case, involving a 22-year-old man in Omaha, is published in the World Journal of Gastroenterology where doctors were also told to consider it when treating people with unexplained vomiting.

"Given the high prevalence of chronic cannabis abuse worldwide and the paucity of reports in the literature, clinicians need to be more attentive to the clinical features of this under-recognised condition," writes Dr Siva Sontineni, and colleagues, from the Creighton University Medical Centre.

In the US case, the sufferer had been smoking marijuana daily and in heavy doses for six years. This eventually led to bouts of vomiting lasting two to three hours daily, and this was worse after meals.

As with South Australian cases, the young man initially turned to "compulsive hot bathing behaviour" to relieve the symptoms but he was not cured until he gave up smoking cannabis altogether.

Adelaide-based drug expert and emergency ward doctor, Dr David Caldicott, said he had seen three cases of the illness and it was possibly also under-reported by sufferers.

"We're probably seeing the tip of the iceberg in the emergency departments, it's probably far more common but far milder (in the broader community)," he said.

Little was known about how cumulative cannabis use could lead to vomiting and, particularly, why sufferers would find some relief in hot bathing, Dr Caldicott also said.

"That's a distinct and unanimously recurrent feature of this condition, and we don't know why," he said.

"Grown men, screaming in pain, sweating profusely, vomiting every 30 seconds and demanding to be allowed to use the shower. It's a very dramatic presentation."

Dr Caldicott said the condition had been identified in a small number of cannabis users "but in the medical community it is now considered to be a real condition".

The National Cannabis Prevention and Information Centre, based at the University of NSW, is taking a more conservative approach.

Centre director Jan Copeland said more cases would need to emerge before it could be considered a new syndrome linked to chronic cannabis use.

"It is not unusual for there to be significant mental and physical health complications with this level of cannabis use," Professor Copeland said.

For more information on cannabis, the centre has a free national helpline 1800 304050.

News.com.au
 
this sounds like they're giving a name for the infamous "white out" that occurs when smoking WAY too much pot in one sitting w/o adequate food, drink, or sleep

i know personally that a hot bath or shower does wonders when this happens (ive only had it happen once in a blue moon) but i believe its the result of abuse and not taking your bodys natural signals into consideration
 
"In the US case, the sufferer had been smoking marijuana daily and in heavy doses for six years. This eventually led to bouts of vomiting lasting two to three hours daily, and this was worse after meals."

Well no shit...ABuse can do bad things. MODERATE use, typically won't.
 
I call BS on tha auther.

Want to see a drug that causes real damage, go check out the large ammount of chirosis and delereum tremens in current and recovering alcoholics. That doesnt even take into account the ammount of people killed by drunk drivers on a yearly basis.

There is a movement to legalize and regulate pot once again and those against the idea are digging so far up their asses for anti-cannibis propaganda that they are choking on their own necks...
 
i cant wait to see this eventuate into a treatable condition. its very real, and needs to be investigated further; for both the sake of emergency departments, and the sufferer.

...kytnism...:|
 
This doesn't surprise me. I need to get a hold of the full paper though. Unfortunately a few case studies does not a syndrome make, but the universal prevalence of the hot baths and showers is intriguing.

Cannabinoids are known to have affinity for TRPV receptors. The hot baths make me think that this system might be involved somehow.
 
Eur J Neurosci. 2007 May;25(9):2773-82. Epub 2007 Apr 25.Click here to read Links
Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.
Sharkey KA, Cristino L, Oland LD, Van Sickle MD, Starowicz K, Pittman QJ, Guglielmotti V, Davison JS, Di Marzo V.

Hotchkiss Brain Institute, Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada. [email protected]

Cannabinoid (CB) agonists suppress nausea and vomiting (emesis). Similarly, transient receptor potential vanilloid-1 (TRPV1) receptor agonists are anti-emetic. Arvanil, N-(3-methoxy-4-hydroxy-benzyl)-arachidonamide, is a synthetic 'hybrid' agonist of CB1 and TRPV1 receptors. Anandamide and N-arachidonoyl-dopamine (NADA) are endogenous agonists at both these receptors. We investigated if arvanil, NADA and anandamide were anti-emetic in the ferret and their mechanism of action. All compounds reduced the episodes of emesis in response to morphine 6 glucuronide. These effects were attenuated by AM251, a CB1 antagonist that was pro-emetic per se, and TRPV1 antagonists iodoresiniferatoxin and AMG 9810, which were without pro-emetic effects. Similar sensitivity to arvanil and NADA was found for prodromal signs of emesis. We analysed the distribution of TRPV1 receptors in the ferret brainstem and, for comparison, the co-localization of CB1 and TRPV1 receptors in the mouse brainstem. TRPV1 immunoreactivity was largely restricted to the nucleus of the solitary tract of the ferret, with faint labeling in the dorsal motor nucleus of the vagus and sparse distribution in the area postrema. A similar distribution of TRPV1, and its extensive co-localization with CB1, was observed in the mouse. Our findings suggest that CB1 and TRPV1 receptors in the brainstem play a major role in the control of emesis by agonists of these two receptors. While there appears to be an endogenous 'tone' of CB1 receptors inhibiting emesis, this does not seem to be the case for TRPV1 receptors, indicating that endogenously released endocannabinoids/endovanilloids inhibit emesis preferentially via CB1 receptors.

PMID: 17459108 [PubMed - indexed for MEDLINE]


Also, many strains of cannabis contain very high levels of THCV, which is a CB1 antagonist. It may also be a TRPV1 antagonist, I haven't looked; if it is, that might explain this.
 
The syndrome is characterised by nausea, stomach pain and bouts of vomiting - ill effects which,
I got this from being dependent on heroin from a young age 15ish & even now im sober it effects me. Marijuana is the only thing that eases these pains & enables me to maintain a somewhat normal weight (115lbs 5'7) after years of smoking my weight back up.. Funny the state seems to think im in the wrong for saving my own life by substituting marijuana for heroin.
 
Like kytnism said, its a real condition. I read a brief summary about it in a medical journal once but couldn't find any additional info; it stuck out in my mind because of the showering thing.
 
I can definitely see where this is coming from though, but only if this nausea is experienced after eating and NOT SMOKING

In my deepest periods of potheadedness I do find myself not all that interested in food, and essentaially bulemic when I do eat- if I haven't smoked. It would be interesting to see if not smoking is the key to this syndrome.

I always pinned this on mental issues though. Pot just makes eating so much better that you get really used to it over time, so eventually food just sucks without smoking and your body can't handle it. A combination of being used to awesome taste enhancement, and the antinausea effects.
 
How is it a syndrome if it goes away once you stop using cannabis? 8)

And what is heavy daily usage? A couple grams a day? An oz a day? Even during my heaviest usage period i never vomitted from marijuana. If anything it prevents me from feeling nauseous..when i didn't have it i didn't eat cause i felt nauseous and had no appetite. of course if i went crazy with the munchies and ate a bunch of random shitty food i might puke...but then that has nothing to do with marijuana itself. 8)
 
i cant wait to see this eventuate into a treatable condition. its very real, and needs to be investigated further; for both the sake of emergency departments, and the sufferer.

...kytnism...:|

It's real alright. My dad smokes multiple times daily and he vomits at night quite regularly. We put it down to the tar from the tobacco he smokes with it in the pipe, i must show him this.
 
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Hmmm,

was first identified in a group of about 20 heavy drug users in the Adelaide hills in 2004, and a new case has emerged this time in the US.

clinicians need to be more attentive to the clinical features of this under-recognised condition

We're probably seeing the tip of the iceberg in the emergency departments

Little was known about how cumulative cannabis use could lead to vomiting

Grown men, screaming in pain, sweating profusely, vomiting every 30 seconds and demanding to be allowed to use the shower. It's a very dramatic presentation.

"but in the medical community it is now considered to be a real condition"

So, apart from 20 Aussies and a single US-resident, nothing more is recorded but only hinted at or suspected?
If only the medical world would (have) react(ed) as diligently with SARS, H5N1, HIV and a score of other ailments, and for the general public to enjoy reading about them as much as they enjoy drug-related scary stories. I think it's time for a new genre in literature, so we can keep the news media (coughs) clean.
 
So, apart from 20 Aussies and a single US-resident, nothing more is recorded but only hinted at or suspected?
If only the medical world would (have) react(ed) as diligently with SARS, H5N1, HIV and a score of other ailments, and for the general public to enjoy reading about them as much as they enjoy drug-related scary stories. I think it's time for a new genre in literature, so we can keep the news media (coughs) clean.

What the fuck are you talking about? HIV, SARS and H5N1 were and are still the subject of major research, including government funded research. Even from the very first days of these things appearing they got major press and shortly afterwards article after article appeared in major and minor journals. This is still ongoing. All of these continue to have researched published on them.

You should consider spending less time randomly bolding and instead read these journals you have obviously never looked at. Good God, each of these were major, major issues in the world media, just even just academic journals. If you haven't noticed, this is not the subject of a world wide media storm or even much academic research.
 
yeah, it's probably just a withdrawal effect... I wish they would say if these people were getting sick when they didn't smoke
 
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