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Cannabis for Restless Leg Syndrome?

LubbaLouie said:
Oh wow! Yes, that is what I am noticing as well. I have ramped up rather quickly. What do you take on the non delta 8 days?
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Usually methylphenidate or delta9. I always combine delta8 or 9 with CBD as well. I know there are some dopaminergic drugs for RLS but the side effects may not be great, unless you're really into compulsive gambling I guess although you did mention you're prescribed ropinirol but don't like it. I experienced RLS a long time ago but for me it was an iron thing
 
LubbaLouie said:
No - I'm not on any medication besides Belsomra for sleep. Diphenhydramine most definitely makes my RLS worse. Thanks for responding!
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It's off-topic but what is your experience with suvorexant? Merck's original clinical trials claimed an efficacy similar to that of Zolpidem. We've all learnt to take clinical trials and manufacturers claims about their own products with a grain of salt these days, but it seems that it was atleast true that suvorexant lacks abuse potential.

I tried it 5 years ago, and found it to be ineffective. It didn't produce any psychoactive effects however, which is a huge benefit for sleeping drugs.
 
LubbaLouie said:
oh wow - can you tell me more about the concerns with vaping THC?
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Vaping is fine but what you have to realize as with so many things in life, you're presented with an arsenal or tools and there's only one right tool for the job. I'm Canadian and I like vaping on road trips? Or at festivals at something because vape pens are portable. You can bring them nearly anywhere, in the US/Canada even on a plane.

The problem with vaping is that it's scorching your lungs, and also you're putting a lot of trust into whomever extracted the dope and then formulated/cooked it for you....several users of this web site have had problems. Including me.

When I was into vaping really hard I basically got something called withdrawls that are best avoided. It really wasn't that bad but you won't face that at all with Plane Old Fashioned Weed (POFS, called 'flower').

Weed has been part of the human experience for like about 5,000 years? I think? And in that time it's barely hurt anyone. Vapes on the other hand have already hurt several people I know.

On the balance I don't think it's such a big deal and you sound like you're on the right path. I'll post my notes below.


Weed - good for any time after work
Edibles - good for plane flights or long bus trips
Vapes - Good for extended road trips where you can't bring weed
Hash - Good for parties and stuff but not for every day use

Please let us know if you have any questions. Weed is a passion of mine and I'm glad that you're enjoying it!
 
gordonliddy said:
 Snip
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Vaping is without a doubt the safest and best way to consume Cannibas as a medicine in a long term fashion IF you want to inhale it. I know your point was that there's benefits and trade-offs to each method but I always try to mention the following when vaping vs smoking Cannibas comes up.

Regularly inhaling smoke of any sort but especially that of plant matter can cause lung diseases such as COPD, chronic Bronchitis and emphysema. It also increases your risk of getting respiratory infections.

The link between Cannibas smoke and lung cancer isn't as clear, but it is an undeniable fact that Cannibas smoke contains known carcinogens such as benzopyrenes and a range of other hydrocarbons.
 
gordonliddy said:
Vaping is fine but what you have to realize as with so many things in life, you're presented with an arsenal or tools and there's only one right tool for the job. I'm Canadian and I like vaping on road trips? Or at festivals at something because vape pens are portable. You can bring them nearly anywhere, in the US/Canada even on a plane.

The problem with vaping is that it's scorching your lungs, and also you're putting a lot of trust into whomever extracted the dope and then formulated/cooked it for you....several users of this web site have had problems. Including me.

When I was into vaping really hard I basically got something called withdrawls that are best avoided. It really wasn't that bad but you won't face that at all with Plane Old Fashioned Weed (POFS, called 'flower').

Weed has been part of the human experience for like about 5,000 years? I think? And in that time it's barely hurt anyone. Vapes on the other hand have already hurt several people I know.

On the balance I don't think it's such a big deal and you sound like you're on the right path. I'll post my notes below.


Weed - good for any time after work
Edibles - good for plane flights or long bus trips
Vapes - Good for extended road trips where you can't bring weed
Hash - Good for parties and stuff but not for every day use

Please let us know if you have any questions. Weed is a passion of mine and I'm glad that you're enjoying it!
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Vaping produces less tars than smoking cannabis which impedes the ability of the lungs to clear out particulate. I agree that many of the delta8 vapes can be harmful, I personally wouldn't use them. I only eat delta8. However vaping a high CBD delta9 flower nay be one of the better ways of using inhaled cannabis medicinally as the CBD will help with the anxiety.
 
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gordonliddy said:
Vaping is fine but what you have to realize as with so many things in life, you're presented with an arsenal or tools and there's only one right tool for the job. I'm Canadian and I like vaping on road trips? Or at festivals at something because vape pens are portable. You can bring them nearly anywhere, in the US/Canada even on a plane.

The problem with vaping is that it's scorching your lungs, and also you're putting a lot of trust into whomever extracted the dope and then formulated/cooked it for you....several users of this web site have had problems. Including me.

When I was into vaping really hard I basically got something called withdrawls that are best avoided. It really wasn't that bad but you won't face that at all with Plane Old Fashioned Weed (POFS, called 'flower').

Weed has been part of the human experience for like about 5,000 years? I think? And in that time it's barely hurt anyone. Vapes on the other hand have already hurt several people I know.

On the balance I don't think it's such a big deal and you sound like you're on the right path. I'll post my notes below.


Weed - good for any time after work
Edibles - good for plane flights or long bus trips
Vapes - Good for extended road trips where you can't bring weed
Hash - Good for parties and stuff but not for every day use

Please let us know if you have any questions. Weed is a passion of mine and I'm glad that you're enjoying it!
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Reading this comment, I know very little about thc.. but it was recommended to me for sleep. Will it help?
 
mrs.cortes11@gmail said:
Reading this comment, I know very little about thc.. but it was recommended to me for sleep. Will it help?
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Yes. For best results, learn to roll and smoke a joint about 20 minutes before bed or as needed. This should work in about 80% of cases or more. It's good in the event of stress but you will not be able to drive for example, so make sure that you are in an area where you can lie down and go to bed if you become immediately sleepy. You will have the sensation and judgement of a drunk person so make sure you are in a house where you are comfortable and able to have a glass of water if you become thirsty. Listening to music also helps.

If you are not patient enough to learn how to smoke a joint right away, edible and vapes are also popular options. In time you will find what is best for you.
 
I've had RLS forever and weed doesn't help in the slightest. Maybe a bit of a distraction and if you smoke enough you usually pass out but that seems a bit wasteful. Pregabalin/gabapentin make it much worse for me. 1st line med for RLS here and the first few days on them were torture.
Amphetamines work very well, as do opioids (obviously).
My doc wouldn't put me on ropinirole due to impulse control issues (meth/amphetamine use) so he gave me clonazepam. Weird choice. Anyway, that doesn't work either, it's just building up as a nice stash.

Normal ferritin levels, it seems to be somewhat genetic.

Ime only opioids are true "cures" for RLS. Wish I could be put on something long acting like bupe or methadone.

Amphetamines will totally stop the symptoms but... you aren't getting any sleep. Maybe this implies there's a monoamine part of RLS that excess dopamine can help with. You could use kratom or codeine or another fairly mild opioid but with all these things when you come off them the RLS is agony and i get it in my entire body.
Hot baths give a lot of relief and feel amazing.

Avoid antihistamines like the plague!!!
 
krankbrother said:
Amphetamines will totally stop the symptoms but... you aren't getting any sleep. Maybe this implies there's a monoamine part of RLS that excess dopamine can help with.
...
Ime only opioids are true "cures" for RLS.
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Dopamine tends to counter serotonin, and high serotonin is associated with all sorts of issues. You can get an idea of these by looking at the "side"effects of SSRI drugs.
This paper does link drugs that increase serotonin to RLS - "...antidepressants may induce or worsen restless legs syndrome."

Like amphetamine, opioids also raise dopamine - which in turn counters serotonin - which could explain opioids stop RLS.
Apart from using pro-dopamine drugs, you can fix the dynamics that cause high serotonin in the first place. That's usually down to metabolic function which is explained in this post. That same blog covers serotonin too. The blog is partly based on articles from this site; here's the ones that cover serotonin:

https://raypeat.com/articles/articles/serotonin-depression-aggression.shtml
https://raypeat.com/articles/articles/serotonin-disease-aging-inflammation.shtml
https://raypeat.com/articles/aging/tryptophan-serotonin-aging.shtml

As for immediate practical solutions, these might be worth investigating:
  • Thymoquinone extract (opioid activity)
  • Sodium ascorbate (supports dopamine production)
  • Creatine (reduces withdrawals, supports metabolism via ATP production)
  • Rhodiola rosea (adaptogen, boosts dopamine)
  • Agmatine (endogenous opioids, reduce withdrawals, prevent tolerance build-up for stimulants/opioids)
  • Theanine (stops stress response, sedative, repairs dopamine system via GDNF)
Opioid-sparing items that interact with opioid receptors:
  • Caryophyllene
  • Cannabigerol
  • Myrrh oil
  • Menthol
  • Vanillin
  • Myrcene
  • Pinene
For repairing metabolic function, the focus is on thyroid function and mitochondria (explained in this post)
  • Vitamin B1 (via B-complex)
  • Niacinamide (50-100mg, with meals)
  • Low dose aspirin (81-100mg max per day, why aspirin?)
  • L-Phenylalanine (300-500mg, daily)
  • Creatine (1g daily)
  • CoQ10
  • Ribose
  • Inosine
 
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I have been smoking and using edibles. What got me started again was restless leg and some diabetic neuropathy. It helps alot. My doctor was on board so why not. It def helps me.
 
So I'm not officially diagnosed with this. My father is, though....

And often i find myself unable to sleep because of racing, bouncing thoughts, and a symptom of those is kind of an urge to flex and curl my feet and re-arrange how my knees are resting when I'm on my side.

I even wake up that way. When i start to curl and extend my toes I know there's not a chance of getting back to whatever dream I was just pulled from.

Drugs don't seem to help, and sometimes make it worse. The best way to power through it for me is to just go to bed physically and mentally exhausted. My job does a good job of doing that for me these days, but prior to that I would just use bodyweight exercises followed by a curl-up smoke session with a book. Also a luxury bed helps. I bought a Puffy and it's fucking amazing.

but still, I often find myself up until 2, 3, 4am but I also have SOLID sleep.
 
LubbaLouie said:
oh wow - can you tell me more about the concerns with vaping THC?
Click to expand...
There are no serious concerns with vaping as long as you have a high quality vape and good product from what i have seen. Low quality vapes can contain weird metals and pre filled cartridges can have weird chemicals, but smoking weed is also objectively terrible for the lungs despite what some will say. There is no good way to injest burned plant matter or superheated wax into organs meant to breath air. If you want to protect lungs, get a medical grade vape if you must inhale, but oral is the only safe method. (I smoke and vape by the way, not just being a hater)
 
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