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  • N&PD Moderators: Skorpio

cannabis and opiate brain bondage

No, they act through completely separate receptors, and in my opinion, have completely different effects.
 
Well opiates and cannabinoids do have some link, how and why I don't know if we know, (I certainly don't).

For one, the analgesia induced by CB1 receptor agonists (THC) is sensitive to opioid receptor antagonism, and is highly synergistic with opioid induced anagelsia. Cannabinoid induced analgesia is also potentiated by blocking enzymes which break down endogenous opioids. Also, CB1 knockout mice don't get as "addicted" to opiates and wildtype mice. THC defiantly cause an increase in the release of the endogenous opioids dynorphin A and leucine enkephalin.

So there is some link going on there, exactly how or why is certainly beyound my knowledge
 
As Bilz0r stated above, there is an integral synergy between these two receptor systems in the brain. The activity of one system seems to reinforce the activity of the other. Opioid antagonists block some of the reinforcing effects of alcohol, whose activity is known to be greatly modulated by cannabinoids' effect on retrograde synaptic plasticity. For this reason I could see big pharma pushing a combined opioid and CB1 antagonist as effective drug for addicts trying to quit any habit (read drugs, porn, internet, eating). Blocking both of the pleasure systems- pharmaceutical genious! (That's sarcasm, folks.)

Bilz0r, what do you know about cohabitation, by this i mean endogenous opioids and endocannaboids being released from the same neuron or glial cell.
 
i always thought there was something similiar between opiates and pot. When im high on pot, then do painkillers, i have a real tyough time noticing the opiate effects, seems that pot masks it, or the body high from the two are similiar, but the mental high between opiates and pot and completely different.

So the body high i feel there is a link
 
Well I would imagine that cells which release both endogenous opioids and cannabinoids, would release them from completely different sites, and through different mechanisms.

So you're saying that alcohol effects DSI?
 
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