there shouldnt be any adverse drug interactions, no.
as stated in another thread, cannabis is one of the few drugs you can use with most other drugs and not worry about side effects
from the interaction.
i dont know what lexapro is but i will say be careful when combining methadone with ANYTHING.
you know yourself and your drug dosages better than me so stay safe and have fun.
im sure someone else can shed more light on this matter though.