Cannabinoid carbazole derivative vs. dibenzazepine TCA structures

[Solipsis]

Is there any expected functional relationship between the carbazole structure of cannabinoids like EG-018 and the dibenzazepine TCA's like imipramine?
It looks very similar, do you believe it is a cause for concern? Though I guess that problems would arise mostly from overuse due to cannabinoid tolerance... then who knows what this acts on, also wondering about MAOI contraindications becoming relevant and the like.

 

[Zeds(NCO2CH2CH3)2]

no they arent similar at all carbazole core of eg-018 and imiprinine dibenzazepine core are entirely different, plus imiprinine has a quaternary ammonium salt req for binding (ionic salt bridge interaction), while the jwh compounds, the others and the classical cannabinoids do not have one, ever, not thc, none of them has this, except for a few select new cannabinoids.

No expected effect but if you ask me the the compounds like EG-018 FUB-144 etc, the JWH SERIES, are VERY TOXIC, how you might ask? because there are no god dam conjugatable groups for phase 2 metabolism. THEREFORE, these compounds will linger for a bit as they are also SO GREASY, SO GREASY, they are straight aromatics and hydrocarbon tails. THEY STAY AROUND FOR A WHILE and may even intercalate with DNA(SUPER PLANAR).

Remember the study that came out a few years ago that detailed the metabolism is toxic, YES THEY ARE, the metabolites are produced by epoxidation of the aromatic ring( RING HYDROXYLATION) allowing free radicals in your favorite comrade, YOUR LIVER, so thus they can then be conjugated out and excreted out, BECAUSE OTHERWISE ITS HARD. 2

IF IF IF IF IF IF you REALLLYYY want to do these compounds avoid them do something less harmful instead.
BRING THE FLAME WAR
zedsdead

 

[Solipsis]

lol i love how you are often kinda angry about chemistry, very helpful and instructive in the process though.

There are certainly cannabinoids with primarily naphthyl moieties and the like, that I have always found very ugly for the very reasons you mention - only your story is more elaborate.

What would you consider examples of a minimum of metabolable (sorry for that) groups needed on these structures so that there is no excessive lingering?