Can we make DXM more ketamine like?

[Memantine]

Turn DXM into DXO. It is a much more selective NMDA antagonist.

(or take DXM with CYP3A4 inhibitors / CYP2D6 inducers)

 

[Nagelfar]

Isn't DXO it's primary metabolite already anyway? I always thought making a drug that is kappa selective in the manner of Salvia Divinorum and an NMDAR antagonist, that out of all potential candidates, a DXO derivative may be able to do that. I think those two kinds of altered states would augment one another nicely; usually the Salvia subjective experience is considered one where you get 'stuck in', or fixed into your own POV as a box from where you cannot escape; at large enough doses (if you don't black out due to the trauma of the solipsism of it all) the furniture within your field of vision becomes like appendages that, try as you are inclined to, you cannot move etc. Where the dissociative anesthetic type drugs like DXM make your feel totally detached from your environment, your mind is just cut off from the physical realm. So what would those two, diametrically opposite, experiences that one can subject themselves to feel like, in tandem, if both reaching their respective plateau of aimed for altered state at once?

 

[Memantine]

Yes DXO is. That's why I said (or take DXM with CYP3A4 inhibitors / CYP2D6 inducers)

I believe there is already a number of people that tried combining SD with nitrous oxide, ketamine etc. and yes they say it causes intense loss of ego.

 

[adder]

3-hydroxymorphinan (nor-DXO) is probably a potent NMDA antagonist itself, perhaps even more potent than DXO itself. I can't see a reason why it wouldn't be. Both (+)-Normetazocine and (+)-metazocine are potent NMDA antagonists, and the former is the more potent one with a Ki of 30 nM vs. 41 nM for the latter. I guess the difference might simply be due to the basicity of the amine with secondary amines being more basic than tertiary ones.

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