Pharmacology Can someone please breakdown the pharmacological profile of Kava?

[Juicewrldfan]

I have trouble finding a good breakdown of the full pharmacology of kava. I have some very expensive reputed to be high quality heady kava coming in a day or two and have been trying to find a good breakdown of the pharmacology.

Are there any pros here that can break it down for me please?

 

[Juicewrldfan]

I just found this but I don’t feel it’s specific enough.

https://i.imgur.io/OpIhfTS_d.webp?maxwidth=640&shape=thumb&fidelity=medium

 

[AlsoTapered]

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Annales de Toxicologie Analytique vol. 25 iss. 3 pp.109—119 Chromatographic hair analysis for natural kavalactones and their metabolites. A preliminary study DOI: 10.1051/ata/2013044 a a	Tarbah, Fuad ;Barguil, Yann ;Müller, Claudia ;Rickert, Annette ;Weinmann, Wolfgang ;Nour, Mohammed ;Kintz, Pascal ;[...]	EDP Sciences	2013 Novembre 07		French;English
	Planta Medica vol. 79 iss. 13 Kavalactones as inhibitors of advanced glycation endproducts (AGEs) formation DOI: 10.1055/s-0033-1352456 a a	Upadhyay, A ;Tuenter, E ;Ahmad, R ;Apers, S ;Hermans, N ;Pieters, L	Georg Thieme Verlag KG	2013 August 21		German;English
	The biosynthetic origin of psychoactive kavalactones in kava DOI: 10.1101/294439 posted-content l	Pluskal, Tomáš ;Torrens-Spence, Michael P. ;Fallon, Timothy R. ;De Abreu, Andrea ;Shi, Cindy H. ;Weng, Jing-Ke	Cold Spring Harbor Laboratory	2018 April 04
	Medicine Research vol. 2 iss. 1 pp.20170019—3 Plant-Derived Kavalactones and Their Bioactivities DOI: 10.21127/yaoyimr20170019 a a	Zhang, Nenling ;Wu, Linjing ;Liu, Xiang ;Shen, Xiangchun	Yaoyi International Publishing	2018
	BIO-PROTOCOL vol. 8 iss. 18 A Behavioral Assay to Examine the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Excitability DOI: 10.21769/bioprotoc.3008 a a	Kautu, Bwarenaba ;Chappel, Jessie ;Steele, Kellie ;Phillips, Juliana ;Mengarelli, M.	Bio-Protocol, LLC	2018
	Neural Regeneration Research vol. 10 iss. 6 pp.875 Neuroprotective properties of kavalactones DOI: 10.4103/1673-5374.158335 a a	Lee, Meng-Jen ;Tzeng, Yew-Min	Medknow	2015		English
	ChemInform vol. 35 iss. 45 pp.0—0 Versatile Asymmetric Synthesis of the Kavalactones: First Synthesis of (+)-Kavain. DOI: 10.1002/chin.200445231 a a	Thomas E. Smith; Mabel Djang; Alan J. Velander; C. Wade Downey; Kathleen A. Carroll; Sophie van Alphen		2004 November 09
	ChemInform vol. 41 iss. 2 pp.0—0 ChemInform Abstract: Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones. DOI: 10.1002/chin.201002079 a a	Angelica Venturini Moro; Flavio Sega Pereira Cardoso; Carlos Roque Duarte Correia		2010 January 12
	Analytica Chimica Acta vol. 501 iss. 2 pp.175—181 Pressurized fluid extraction of carotenoids from Haematococcus pluvialis and Dunaliella salina and kavalactones from Piper methysticum DOI: 10.1016/j.aca.2003.09.026 a a	Judith R Denery; Klaus Dragull; C.S Tang; Qing X Li		2004 January		English;French;German
	Journal of Chromatography B vol. 812 iss. 1-2 pp.203—214 Analysis of kavalactones from Piper methysticum (kava-kava) DOI: 10.1016/j.jchromb.2004.07.038 a a	Anna Rita Bilia; Luca Scalise; Maria Camilla Bergonzi; Franco F. Vincieri		2004		English
	Journal of Pharmaceutical and Biomedical Analysis vol. 52 iss. 4 pp.479—483 Cyclodextrins as carriers for kavalactones in aqueous media: Spectroscopic characterization of (S)-7,8-dihydrokavain and β-cyclodextrin inclusion complex DOI: 10.1016/j.jpba.2010.01.037 a a	G. Pescitelli; A.R. Bilia; M.C. Bergonzi; F.F. Vincieri; L. Di Bari		2010 August		English
	Tetrahedron Letters vol. 47 iss. 49 pp.8657—8660 Chemoenzymatic synthesis of enantiomerically enriched kavalactones DOI: 10.1016/j.tetlet.2006.09.155 a a	Ahmed Kamal; Tadiparthi Krishnaji; G.B. Ramesh Khanna		2006 Décembre		French;German;English
	Journal of Chromatography A vol. 825 iss. 1 pp.1—8 Reversed-phase high-performance liquid chromatographic method for quantitative analysis of the six major kavalactones in Piper methysticum DOI: 10.1016/s0021-9673(98)00699-2 a a	Yu Shao; Kan He; Bolin Zheng; Qunyi Zheng		1998 October		English
	Journal of Chromatography A vol. 848 iss. 1-2 pp.457—464 Qualitative and quantitative micellar electrokinetic chromatography of kavalactones from dry extracts of Piper methysticum Forst. and commercial drugs DOI: 10.1016/s0021-9673(99)00425-2 a a	Matthias Lechtenberg; Bettina Quandt; Franz-Josef Kohlenberg; Adolf Nahrstedt		1999 July		English
	Phytochemistry vol. 59 iss. 4 pp.429—433 Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses DOI: 10.1016/s0031-9422(01)00443-5 a a	H Ranjith W. Dharmaratne; N.P Dhammika Nanayakkara; Ikhlas A Khan		2002 February		English
	Phytochemical Analysis vol. 18 iss. 2 pp.98—102 Comparison of the capabilities of accelerated solvent extraction and sonication as extraction techniques for the quantification of kavalactones in piper methysticum (Kava) roots by high performance liquid chromatography with ultra violet detection DOI: 10.1002/pca.955 a a	Emma Warburton; Paul L Norris; Heidi Goenaga-Infante		2007 March		English
	Phytotherapy Research vol. 25 iss. 3 pp.n/a—n/a Kavalactones Yangonin and Methysticin Induce Apoptosis in Human Hepatocytes (HepG2) In Vitro DOI: 10.1002/ptr.3283 a a	J. Tang; R. A. Dunlop; A. Rowe; K. J. Rodgers; I. Ramzan		2010 August 23		English
	Psychopharmacology vol. 155 iss. 1 pp.86—90 Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm DOI: 10.1007/s002130100686 a a	Kenyatta K. Smith; H. Ranjith W. Dharmaratne; Matt W. Feltenstein; Susan L. Broom; J. Todd Roach; N.P. Dhammika Nanayakkara;[...]		2001 March 15		English
	Journal of Clinical Pharmacy and Therapeutics vol. 32 iss. 3 pp.233—239 Permeability studies of Kavalactones using a Caco-2 cell monolayer model DOI: 10.1111/j.1365-2710.2007.00810.x a a	A. Matthias; J. T. Blanchfield; K. G. Penman; K. M. Bone; I. Toth; R. P. Lehmann		2007 June		English
	Journal of Food Science vol. 71 iss. 6 pp.C345—C351 Assessment of Kavalactones in Kava Beverage Products and Aqueous Infusions DOI: 10.1111/j.1750-3841.2006.00102.x a a	J.-W. Jhoo; J. P. Freeman; C. Y. W. Ang; J. J. Mihalov		2006 August		English
	European Journal of Organic Chemistry vol. 2012 iss. 19 pp.3607—3616 Heck–Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues DOI: 10.1002/ejoc.201200308 a a	Cristian Soldi; Angélica V. Moro; Moacir G. Pizzolatti; Carlos R. D. Correia		2012 May 22		English
	Phytotherapy Research vol. 26 iss. 12 pp.1934—1941 Pacific Island 'Awa (Kava) Extracts, but not Isolated Kavalactones, Promote Proinflammatory Responses in Model Mast Cells DOI: 10.1002/ptr.4652 a a	Lori M. N. Shimoda; Christy Park; Alexander J. Stokes; Henry Halenani Gomes; Helen Turner		2012 April 04		English
	Phytomedicine vol. 13 iss. 3 pp.192—195 Kavalactones fail to inhibit alcohol dehydrogenase in vitro DOI: 10.1016/j.phymed.2004.07.005 a a	J. Anke; S. Fu; I. Ramzan		2006 February		English
	ChemInform vol. 43 iss. 48 pp.no—no ChemInform Abstract: Heck-Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues. DOI: 10.1002/chin.201248136 a a	Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.		2012 November 08
	Pharmacological Research vol. 66 iss. 2 pp.163—169 Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB1 receptor ligand DOI: 10.1016/j.phrs.2012.04.003 a a

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Organic Letters vol. 11 iss. 16 pp.3642—3645 Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones DOI: 10.1021/ol901416e a a	Moro, Angélica Venturini; Cardoso, Flávio Sega Pereira; Correia, Carlos Roque Duarte		2009 August 20		English
	Journal of Food Science and Technology vol. 52 iss. 2 pp.1164—1169 Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents DOI: 10.1007/s13197-013-1047-2 a a	Wang, Jun; Qu, Weiyue; Bittenbender, Harry C.; Li, Qing X.		2013 June 25		English
	Drug Metabolism and Disposition vol. 30 iss. 11 pp.1153—1157 Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones DOI: 10.1124/dmd.30.11.1153 a a	Mathews, J. M.		2002 November 01		English
	Journal of Agricultural and Food Chemistry vol. 56 iss. 13 pp.4976—4981 Quantification of Kavalactones and Determination of Kava (Piper methysticum) Chemotypes Using Near-Infrared Reflectance Spectroscopy for Quality Control in Vanuatu DOI: 10.1021/jf800439g a a	Lasme, Privat; Davrieux, Fabrice; Montet, Didier; Lebot, Vincent		2008 July		English
	Journal of Agricultural and Food Chemistry vol. 54 iss. 17 pp.6147—6152 Determination of Kavalactones in Dried Kava ( Piper methysticum ) Powder Using Near-Infrared Reflectance Spectroscopy and Partial Least-Squares Regression DOI: 10.1021/jf060964v a a	Gautz, Loren D.; Kaufusi, Pakieli; Jackson, Mel C.; Bittenbender, Harry C.; Tang, Chung-Shih		2006 August		English
	Organic Letters vol. 6 iss. 14 pp.2317—2320 Versatile Asymmetric Synthesis of the Kavalactones:  First Synthesis of (+)-Kavain DOI: 10.1021/ol0493960 a a	Smith, Thomas E.; Djang, Mabel; Velander, Alan J.; Downey, C. Wade; Carroll, Kathleen A.; van Alphen, Sophie		2004 July		English
	Analytical Methods vol. 2 iss. 5 pp.492 Rapid determination of six kavalactones in kava root and rhizome samples using Fourier transform infrared spectroscopy and multivariate analysis in comparison with gas chromatography DOI: 10.1039/c0ay00021c a a	Wang, Jun; Qu, Weiyue; Jun, Soojin; Bittenbender, Harry C.; Li, Qing X.		2010		English
	Drug Development and Industrial Pharmacy vol. 23 iss. 12 pp.1223—1226 Selection of Kavalactones by Complexation of Kava Extract with Cyclodextrins DOI: 10.3109/03639049709146161 a a	Amdidouche-hussain, Didja; Levesque, Joel		1997 January		English
	Journal of Bioscience and Bioengineering vol. 118 iss. 6 pp.679—688 Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells DOI: 10.1016/j.jbiosc.2014.05.009 a a	Rao, Yerra Koteswara; Shih, Hui-Nung; Lee, Yi-Ching; Cheng, Wen-Tai; Hung, Hui-Chin; Wang, Huang-Chi;[...]		2014 December		English
	Toxicological Sciences vol. 124 iss. 2 pp.388—399 Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1 DOI: 10.1093/toxsci/kfr235 a a	Li, Y.; Mei, H.; Wu, Q.; Zhang, S.; Fang, J.-L.; Shi, L.; Guo, L.		2011 September 09		English
	Journal of Liquid Chromatography & Related Technologies vol. 28 iss. 11 pp.1703—1716 Application of High Speed Countercurrent Chromatography (HSCCC) to the Isolation of Kavalactones DOI: 10.1081/jlc-200060451 a a	Schäfer, Katrien; Winterhalter, Peter		2005 June		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.187—188 Response to Schmidt "Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory" DOI: 10.1089/10755530360623293 a a	Whitton, Peter A.		2003 April		English
	Drug Metabolism and Disposition vol. 32 iss. 11 pp.1317—1324 DESMETHOXYYANGONIN AND DIHYDROMETHYSTICIN ARE TWO MAJOR PHARMACOLOGICAL KAVALACTONES WITH MARKED ACTIVITY ON THE INDUCTION OF CYP3A23 DOI: 10.1124/dmd.104.000786 a a	Ma, Y.		2004 July 28		English
	Molecular Pharmacology vol. 73 iss. 6 pp.1785—1795 Kavalactones Protect Neural Cells against Amyloid Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation DOI: 10.1124/mol.107.042499 a a	Wruck, C. J.; Gotz, M. E.; Herdegen, T.; Varoga, D.; Brandenburg, L.-O.; Pufe, T.		2008 March 11		English
	Drug Metabolism and Disposition vol. 33 iss. 10 pp.1555—1563 PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO DOI: 10.1124/dmd.105.004317 a a	Mathews, J. M.		2005 July 20		English
	Toxicological Sciences vol. 79 iss. 1 pp.106—111 In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones DOI: 10.1093/toxsci/kfh067 a a	Nerurkar, P. V.		2004 January 21		English
	Drug Metabolism and Disposition vol. 33 iss. 11 pp.1580—1583 EXTRACTS AND KAVALACTONES OF PIPER METHYSTICUM G. FORST (KAVA-KAVA) INHIBIT P-GLYCOPROTEIN IN VITRO DOI: 10.1124/dmd.105.005892 a a	Weiss, J.		2005 July 28		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.183—187 Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory DOI: 10.1089/10755530360623284 a a	Schmidt, Mathias		2003 April		English
	Toxicological Sciences vol. 97 iss. 1 pp.214—221 Effects of Kava Alkaloid, Pipermethystine, and Kavalactones on Oxidative Stress and Cytochrome P450 in F-344 Rats DOI: 10.1093/toxsci/kfm035 a a	Lim, S. T.S.; Dragull, K.; Tang, C.-S.; Bittenbender, H. C.; Efird, J. T.; Nerurkar, P. V.		2007 May 01		English
	Planta Medica vol. 80 iss. 12 pp.1001—1008 Kavalactones, A Novel Class of Protein Glycation and Lipid Peroxidation Inhibitors DOI: 10.1055/s-0034-1382949 a a	Upadhyay, Atul; Tuenter, Emmy; Ahmad, Rizwan; Amin, Adnan; Exarchou, Vasiliki; Apers, Sandra; Hermans, Nina;[...]		2014 August 06		German;English
	Planta Medica vol. 68 iss. 12 pp.1055—1058 Inhibition of Cytochrome P450 3A4 by Extracts and Kavalactones of Piper methysticum (Kava-Kava) DOI: 10.1055/s-2002-36360 a a	Unger, Matthias; Holzgrabe, Ulrike; Jacobsen, Wolfgang; Cummins, Carolyn; Benet, Leslie Z.		2002 Dezember		German;English
	Planta Medica vol. 68 iss. 12 pp.1092—1096 Kavalactones and Dihydrokavain Modulate GABAergic Activity in a Rat Gastric-Brainstem Preparation DOI: 10.1055/s-2002-36338 a a	Yuan, Chun-Su; Dey, Lucy; Wang, Anbao; Mehendale, Sangeeta; Xie, Jing-Tian; Aung, Han H.; Ang-Lee, Michael K.		2002 Dezember		German;English
	European Journal of Mass Spectrometry vol. 12 iss. 4 pp.223—233 Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation DOI: 10.1255/ejms.808 a a	Warburton, Emma; Bristow, Tony		2006 August
	Biological & Pharmaceutical Bulletin vol. 29 iss. 4 pp.834—837 Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones DOI: 10.1248/bpb.29.834 a a	Matsuda, Hideaki; Hirata, Noriko; Kawaguchi, Yoshiko; Naruto, Shunsuke; Takata, Takanobu; Oyama, Masayoshi;[...]		2006		English
	Journal of Experimental Neuroscience vol. 11 pp.117906951770538 A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Transmission DOI: 10.1177/1179069517705384 a a	Kautu, Bwarenaba B; Phillips, Juliana; Steele, Kellie; Mengarelli, M Shawn; Nord, Eric A

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Organic Letters vol. 11 iss. 16 pp.3642—3645 Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones DOI: 10.1021/ol901416e a a	Moro, Angélica Venturini; Cardoso, Flávio Sega Pereira; Correia, Carlos Roque Duarte		2009 August 20		English
	Journal of Food Science and Technology vol. 52 iss. 2 pp.1164—1169 Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents DOI: 10.1007/s13197-013-1047-2 a a	Wang, Jun; Qu, Weiyue; Bittenbender, Harry C.; Li, Qing X.		2013 June 25		English
	Drug Metabolism and Disposition vol. 30 iss. 11 pp.1153—1157 Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones DOI: 10.1124/dmd.30.11.1153 a a	Mathews, J. M.		2002 November 01		English
	Journal of Agricultural and Food Chemistry vol. 56 iss. 13 pp.4976—4981 Quantification of Kavalactones and Determination of Kava (Piper methysticum) Chemotypes Using Near-Infrared Reflectance Spectroscopy for Quality Control in Vanuatu DOI: 10.1021/jf800439g a a	Lasme, Privat; Davrieux, Fabrice; Montet, Didier; Lebot, Vincent		2008 July		English
	Journal of Agricultural and Food Chemistry vol. 54 iss. 17 pp.6147—6152 Determination of Kavalactones in Dried Kava ( Piper methysticum ) Powder Using Near-Infrared Reflectance Spectroscopy and Partial Least-Squares Regression DOI: 10.1021/jf060964v a a	Gautz, Loren D.; Kaufusi, Pakieli; Jackson, Mel C.; Bittenbender, Harry C.; Tang, Chung-Shih		2006 August		English
	Organic Letters vol. 6 iss. 14 pp.2317—2320 Versatile Asymmetric Synthesis of the Kavalactones:  First Synthesis of (+)-Kavain DOI: 10.1021/ol0493960 a a	Smith, Thomas E.; Djang, Mabel; Velander, Alan J.; Downey, C. Wade; Carroll, Kathleen A.; van Alphen, Sophie		2004 July		English
	Analytical Methods vol. 2 iss. 5 pp.492 Rapid determination of six kavalactones in kava root and rhizome samples using Fourier transform infrared spectroscopy and multivariate analysis in comparison with gas chromatography DOI: 10.1039/c0ay00021c a a	Wang, Jun; Qu, Weiyue; Jun, Soojin; Bittenbender, Harry C.; Li, Qing X.		2010		English
	Drug Development and Industrial Pharmacy vol. 23 iss. 12 pp.1223—1226 Selection of Kavalactones by Complexation of Kava Extract with Cyclodextrins DOI: 10.3109/03639049709146161 a a	Amdidouche-hussain, Didja; Levesque, Joel		1997 January		English
	Journal of Bioscience and Bioengineering vol. 118 iss. 6 pp.679—688 Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells DOI: 10.1016/j.jbiosc.2014.05.009 a a	Rao, Yerra Koteswara; Shih, Hui-Nung; Lee, Yi-Ching; Cheng, Wen-Tai; Hung, Hui-Chin; Wang, Huang-Chi;[...]		2014 December		English
	Toxicological Sciences vol. 124 iss. 2 pp.388—399 Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1 DOI: 10.1093/toxsci/kfr235 a a	Li, Y.; Mei, H.; Wu, Q.; Zhang, S.; Fang, J.-L.; Shi, L.; Guo, L.		2011 September 09		English
	Journal of Liquid Chromatography & Related Technologies vol. 28 iss. 11 pp.1703—1716 Application of High Speed Countercurrent Chromatography (HSCCC) to the Isolation of Kavalactones DOI: 10.1081/jlc-200060451 a a	Schäfer, Katrien; Winterhalter, Peter		2005 June		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.187—188 Response to Schmidt "Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory" DOI: 10.1089/10755530360623293 a a	Whitton, Peter A.		2003 April		English
	Drug Metabolism and Disposition vol. 32 iss. 11 pp.1317—1324 DESMETHOXYYANGONIN AND DIHYDROMETHYSTICIN ARE TWO MAJOR PHARMACOLOGICAL KAVALACTONES WITH MARKED ACTIVITY ON THE INDUCTION OF CYP3A23 DOI: 10.1124/dmd.104.000786 a a	Ma, Y.		2004 July 28		English
	Molecular Pharmacology vol. 73 iss. 6 pp.1785—1795 Kavalactones Protect Neural Cells against Amyloid Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation DOI: 10.1124/mol.107.042499 a a	Wruck, C. J.; Gotz, M. E.; Herdegen, T.; Varoga, D.; Brandenburg, L.-O.; Pufe, T.		2008 March 11		English
	Drug Metabolism and Disposition vol. 33 iss. 10 pp.1555—1563 PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO DOI: 10.1124/dmd.105.004317 a a	Mathews, J. M.		2005 July 20		English
	Toxicological Sciences vol. 79 iss. 1 pp.106—111 In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones DOI: 10.1093/toxsci/kfh067 a a	Nerurkar, P. V.		2004 January 21		English
	Drug Metabolism and Disposition vol. 33 iss. 11 pp.1580—1583 EXTRACTS AND KAVALACTONES OF PIPER METHYSTICUM G. FORST (KAVA-KAVA) INHIBIT P-GLYCOPROTEIN IN VITRO DOI: 10.1124/dmd.105.005892 a a	Weiss, J.		2005 July 28		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.183—187 Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory DOI: 10.1089/10755530360623284 a a	Schmidt, Mathias		2003 April		English
	Toxicological Sciences vol. 97 iss. 1 pp.214—221 Effects of Kava Alkaloid, Pipermethystine, and Kavalactones on Oxidative Stress and Cytochrome P450 in F-344 Rats DOI: 10.1093/toxsci/kfm035 a a	Lim, S. T.S.; Dragull, K.; Tang, C.-S.; Bittenbender, H. C.; Efird, J. T.; Nerurkar, P. V.		2007 May 01		English
	Planta Medica vol. 80 iss. 12 pp.1001—1008 Kavalactones, A Novel Class of Protein Glycation and Lipid Peroxidation Inhibitors DOI: 10.1055/s-0034-1382949 a a	Upadhyay, Atul; Tuenter, Emmy; Ahmad, Rizwan; Amin, Adnan; Exarchou, Vasiliki; Apers, Sandra; Hermans, Nina;[...]		2014 August 06		German;English
	Planta Medica vol. 68 iss. 12 pp.1055—1058 Inhibition of Cytochrome P450 3A4 by Extracts and Kavalactones of Piper methysticum (Kava-Kava) DOI: 10.1055/s-2002-36360 a a	Unger, Matthias; Holzgrabe, Ulrike; Jacobsen, Wolfgang; Cummins, Carolyn; Benet, Leslie Z.		2002 Dezember		German;English
	Planta Medica vol. 68 iss. 12 pp.1092—1096 Kavalactones and Dihydrokavain Modulate GABAergic Activity in a Rat Gastric-Brainstem Preparation DOI: 10.1055/s-2002-36338 a a	Yuan, Chun-Su; Dey, Lucy; Wang, Anbao; Mehendale, Sangeeta; Xie, Jing-Tian; Aung, Han H.; Ang-Lee, Michael K.		2002 Dezember		German;English
	European Journal of Mass Spectrometry vol. 12 iss. 4 pp.223—233 Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation DOI: 10.1255/ejms.808 a a	Warburton, Emma; Bristow, Tony		2006 August
	Biological & Pharmaceutical Bulletin vol. 29 iss. 4 pp.834—837 Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones DOI: 10.1248/bpb.29.834 a a	Matsuda, Hideaki; Hirata, Noriko; Kawaguchi, Yoshiko; Naruto, Shunsuke; Takata, Takanobu; Oyama, Masayoshi;[...]		2006		English
	Journal of Experimental Neuroscience vol. 11 pp.117906951770538 A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Transmission DOI: 10.1177/1179069517705384 a a	Kautu, Bwarenaba B; Phillips, Juliana; Steele, Kellie; Mengarelli, M Shawn; Nord, Eric A

The above are all hotlinks to the .PDF files of the papers named.

 

[Juicewrldfan]

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Annales de Toxicologie Analytique vol. 25 iss. 3 pp.109—119 Chromatographic hair analysis for natural kavalactones and their metabolites. A preliminary study DOI: 10.1051/ata/2013044 a a	Tarbah, Fuad ;Barguil, Yann ;Müller, Claudia ;Rickert, Annette ;Weinmann, Wolfgang ;Nour, Mohammed ;Kintz, Pascal ;[...]	EDP Sciences	2013 Novembre 07		French;English
	Planta Medica vol. 79 iss. 13 Kavalactones as inhibitors of advanced glycation endproducts (AGEs) formation DOI: 10.1055/s-0033-1352456 a a	Upadhyay, A ;Tuenter, E ;Ahmad, R ;Apers, S ;Hermans, N ;Pieters, L	Georg Thieme Verlag KG	2013 August 21		German;English
	The biosynthetic origin of psychoactive kavalactones in kava DOI: 10.1101/294439 posted-content l	Pluskal, Tomáš ;Torrens-Spence, Michael P. ;Fallon, Timothy R. ;De Abreu, Andrea ;Shi, Cindy H. ;Weng, Jing-Ke	Cold Spring Harbor Laboratory	2018 April 04
	Medicine Research vol. 2 iss. 1 pp.20170019—3 Plant-Derived Kavalactones and Their Bioactivities DOI: 10.21127/yaoyimr20170019 a a	Zhang, Nenling ;Wu, Linjing ;Liu, Xiang ;Shen, Xiangchun	Yaoyi International Publishing	2018
	BIO-PROTOCOL vol. 8 iss. 18 A Behavioral Assay to Examine the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Excitability DOI: 10.21769/bioprotoc.3008 a a	Kautu, Bwarenaba ;Chappel, Jessie ;Steele, Kellie ;Phillips, Juliana ;Mengarelli, M.	Bio-Protocol, LLC	2018
	Neural Regeneration Research vol. 10 iss. 6 pp.875 Neuroprotective properties of kavalactones DOI: 10.4103/1673-5374.158335 a a	Lee, Meng-Jen ;Tzeng, Yew-Min	Medknow	2015		English
	ChemInform vol. 35 iss. 45 pp.0—0 Versatile Asymmetric Synthesis of the Kavalactones: First Synthesis of (+)-Kavain. DOI: 10.1002/chin.200445231 a a	Thomas E. Smith; Mabel Djang; Alan J. Velander; C. Wade Downey; Kathleen A. Carroll; Sophie van Alphen		2004 November 09
	ChemInform vol. 41 iss. 2 pp.0—0 ChemInform Abstract: Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones. DOI: 10.1002/chin.201002079 a a	Angelica Venturini Moro; Flavio Sega Pereira Cardoso; Carlos Roque Duarte Correia		2010 January 12
	Analytica Chimica Acta vol. 501 iss. 2 pp.175—181 Pressurized fluid extraction of carotenoids from Haematococcus pluvialis and Dunaliella salina and kavalactones from Piper methysticum DOI: 10.1016/j.aca.2003.09.026 a a	Judith R Denery; Klaus Dragull; C.S Tang; Qing X Li		2004 January		English;French;German
	Journal of Chromatography B vol. 812 iss. 1-2 pp.203—214 Analysis of kavalactones from Piper methysticum (kava-kava) DOI: 10.1016/j.jchromb.2004.07.038 a a	Anna Rita Bilia; Luca Scalise; Maria Camilla Bergonzi; Franco F. Vincieri		2004		English
	Journal of Pharmaceutical and Biomedical Analysis vol. 52 iss. 4 pp.479—483 Cyclodextrins as carriers for kavalactones in aqueous media: Spectroscopic characterization of (S)-7,8-dihydrokavain and β-cyclodextrin inclusion complex DOI: 10.1016/j.jpba.2010.01.037 a a	G. Pescitelli; A.R. Bilia; M.C. Bergonzi; F.F. Vincieri; L. Di Bari		2010 August		English
	Tetrahedron Letters vol. 47 iss. 49 pp.8657—8660 Chemoenzymatic synthesis of enantiomerically enriched kavalactones DOI: 10.1016/j.tetlet.2006.09.155 a a	Ahmed Kamal; Tadiparthi Krishnaji; G.B. Ramesh Khanna		2006 Décembre		French;German;English
	Journal of Chromatography A vol. 825 iss. 1 pp.1—8 Reversed-phase high-performance liquid chromatographic method for quantitative analysis of the six major kavalactones in Piper methysticum DOI: 10.1016/s0021-9673(98)00699-2 a a	Yu Shao; Kan He; Bolin Zheng; Qunyi Zheng		1998 October		English
	Journal of Chromatography A vol. 848 iss. 1-2 pp.457—464 Qualitative and quantitative micellar electrokinetic chromatography of kavalactones from dry extracts of Piper methysticum Forst. and commercial drugs DOI: 10.1016/s0021-9673(99)00425-2 a a	Matthias Lechtenberg; Bettina Quandt; Franz-Josef Kohlenberg; Adolf Nahrstedt		1999 July		English
	Phytochemistry vol. 59 iss. 4 pp.429—433 Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses DOI: 10.1016/s0031-9422(01)00443-5 a a	H Ranjith W. Dharmaratne; N.P Dhammika Nanayakkara; Ikhlas A Khan		2002 February		English
	Phytochemical Analysis vol. 18 iss. 2 pp.98—102 Comparison of the capabilities of accelerated solvent extraction and sonication as extraction techniques for the quantification of kavalactones in piper methysticum (Kava) roots by high performance liquid chromatography with ultra violet detection DOI: 10.1002/pca.955 a a	Emma Warburton; Paul L Norris; Heidi Goenaga-Infante		2007 March		English
	Phytotherapy Research vol. 25 iss. 3 pp.n/a—n/a Kavalactones Yangonin and Methysticin Induce Apoptosis in Human Hepatocytes (HepG2) In Vitro DOI: 10.1002/ptr.3283 a a	J. Tang; R. A. Dunlop; A. Rowe; K. J. Rodgers; I. Ramzan		2010 August 23		English
	Psychopharmacology vol. 155 iss. 1 pp.86—90 Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm DOI: 10.1007/s002130100686 a a	Kenyatta K. Smith; H. Ranjith W. Dharmaratne; Matt W. Feltenstein; Susan L. Broom; J. Todd Roach; N.P. Dhammika Nanayakkara;[...]		2001 March 15		English
	Journal of Clinical Pharmacy and Therapeutics vol. 32 iss. 3 pp.233—239 Permeability studies of Kavalactones using a Caco-2 cell monolayer model DOI: 10.1111/j.1365-2710.2007.00810.x a a	A. Matthias; J. T. Blanchfield; K. G. Penman; K. M. Bone; I. Toth; R. P. Lehmann		2007 June		English
	Journal of Food Science vol. 71 iss. 6 pp.C345—C351 Assessment of Kavalactones in Kava Beverage Products and Aqueous Infusions DOI: 10.1111/j.1750-3841.2006.00102.x a a	J.-W. Jhoo; J. P. Freeman; C. Y. W. Ang; J. J. Mihalov		2006 August		English
	European Journal of Organic Chemistry vol. 2012 iss. 19 pp.3607—3616 Heck–Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues DOI: 10.1002/ejoc.201200308 a a	Cristian Soldi; Angélica V. Moro; Moacir G. Pizzolatti; Carlos R. D. Correia		2012 May 22		English
	Phytotherapy Research vol. 26 iss. 12 pp.1934—1941 Pacific Island 'Awa (Kava) Extracts, but not Isolated Kavalactones, Promote Proinflammatory Responses in Model Mast Cells DOI: 10.1002/ptr.4652 a a	Lori M. N. Shimoda; Christy Park; Alexander J. Stokes; Henry Halenani Gomes; Helen Turner		2012 April 04		English
	Phytomedicine vol. 13 iss. 3 pp.192—195 Kavalactones fail to inhibit alcohol dehydrogenase in vitro DOI: 10.1016/j.phymed.2004.07.005 a a	J. Anke; S. Fu; I. Ramzan		2006 February		English
	ChemInform vol. 43 iss. 48 pp.no—no ChemInform Abstract: Heck-Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues. DOI: 10.1002/chin.201248136 a a	Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.		2012 November 08
	Pharmacological Research vol. 66 iss. 2 pp.163—169 Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB1 receptor ligand DOI: 10.1016/j.phrs.2012.04.003 a a

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Organic Letters vol. 11 iss. 16 pp.3642—3645 Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones DOI: 10.1021/ol901416e a a	Moro, Angélica Venturini; Cardoso, Flávio Sega Pereira; Correia, Carlos Roque Duarte		2009 August 20		English
	Journal of Food Science and Technology vol. 52 iss. 2 pp.1164—1169 Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents DOI: 10.1007/s13197-013-1047-2 a a	Wang, Jun; Qu, Weiyue; Bittenbender, Harry C.; Li, Qing X.		2013 June 25		English
	Drug Metabolism and Disposition vol. 30 iss. 11 pp.1153—1157 Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones DOI: 10.1124/dmd.30.11.1153 a a	Mathews, J. M.		2002 November 01		English
	Journal of Agricultural and Food Chemistry vol. 56 iss. 13 pp.4976—4981 Quantification of Kavalactones and Determination of Kava (Piper methysticum) Chemotypes Using Near-Infrared Reflectance Spectroscopy for Quality Control in Vanuatu DOI: 10.1021/jf800439g a a	Lasme, Privat; Davrieux, Fabrice; Montet, Didier; Lebot, Vincent		2008 July		English
	Journal of Agricultural and Food Chemistry vol. 54 iss. 17 pp.6147—6152 Determination of Kavalactones in Dried Kava ( Piper methysticum ) Powder Using Near-Infrared Reflectance Spectroscopy and Partial Least-Squares Regression DOI: 10.1021/jf060964v a a	Gautz, Loren D.; Kaufusi, Pakieli; Jackson, Mel C.; Bittenbender, Harry C.; Tang, Chung-Shih		2006 August		English
	Organic Letters vol. 6 iss. 14 pp.2317—2320 Versatile Asymmetric Synthesis of the Kavalactones:  First Synthesis of (+)-Kavain DOI: 10.1021/ol0493960 a a	Smith, Thomas E.; Djang, Mabel; Velander, Alan J.; Downey, C. Wade; Carroll, Kathleen A.; van Alphen, Sophie		2004 July		English
	Analytical Methods vol. 2 iss. 5 pp.492 Rapid determination of six kavalactones in kava root and rhizome samples using Fourier transform infrared spectroscopy and multivariate analysis in comparison with gas chromatography DOI: 10.1039/c0ay00021c a a	Wang, Jun; Qu, Weiyue; Jun, Soojin; Bittenbender, Harry C.; Li, Qing X.		2010		English
	Drug Development and Industrial Pharmacy vol. 23 iss. 12 pp.1223—1226 Selection of Kavalactones by Complexation of Kava Extract with Cyclodextrins DOI: 10.3109/03639049709146161 a a	Amdidouche-hussain, Didja; Levesque, Joel		1997 January		English
	Journal of Bioscience and Bioengineering vol. 118 iss. 6 pp.679—688 Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells DOI: 10.1016/j.jbiosc.2014.05.009 a a	Rao, Yerra Koteswara; Shih, Hui-Nung; Lee, Yi-Ching; Cheng, Wen-Tai; Hung, Hui-Chin; Wang, Huang-Chi;[...]		2014 December		English
	Toxicological Sciences vol. 124 iss. 2 pp.388—399 Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1 DOI: 10.1093/toxsci/kfr235 a a	Li, Y.; Mei, H.; Wu, Q.; Zhang, S.; Fang, J.-L.; Shi, L.; Guo, L.		2011 September 09		English
	Journal of Liquid Chromatography & Related Technologies vol. 28 iss. 11 pp.1703—1716 Application of High Speed Countercurrent Chromatography (HSCCC) to the Isolation of Kavalactones DOI: 10.1081/jlc-200060451 a a	Schäfer, Katrien; Winterhalter, Peter		2005 June		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.187—188 Response to Schmidt "Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory" DOI: 10.1089/10755530360623293 a a	Whitton, Peter A.		2003 April		English
	Drug Metabolism and Disposition vol. 32 iss. 11 pp.1317—1324 DESMETHOXYYANGONIN AND DIHYDROMETHYSTICIN ARE TWO MAJOR PHARMACOLOGICAL KAVALACTONES WITH MARKED ACTIVITY ON THE INDUCTION OF CYP3A23 DOI: 10.1124/dmd.104.000786 a a	Ma, Y.		2004 July 28		English
	Molecular Pharmacology vol. 73 iss. 6 pp.1785—1795 Kavalactones Protect Neural Cells against Amyloid Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation DOI: 10.1124/mol.107.042499 a a	Wruck, C. J.; Gotz, M. E.; Herdegen, T.; Varoga, D.; Brandenburg, L.-O.; Pufe, T.		2008 March 11		English
	Drug Metabolism and Disposition vol. 33 iss. 10 pp.1555—1563 PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO DOI: 10.1124/dmd.105.004317 a a	Mathews, J. M.		2005 July 20		English
	Toxicological Sciences vol. 79 iss. 1 pp.106—111 In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones DOI: 10.1093/toxsci/kfh067 a a	Nerurkar, P. V.		2004 January 21		English
	Drug Metabolism and Disposition vol. 33 iss. 11 pp.1580—1583 EXTRACTS AND KAVALACTONES OF PIPER METHYSTICUM G. FORST (KAVA-KAVA) INHIBIT P-GLYCOPROTEIN IN VITRO DOI: 10.1124/dmd.105.005892 a a	Weiss, J.		2005 July 28		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.183—187 Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory DOI: 10.1089/10755530360623284 a a	Schmidt, Mathias		2003 April		English
	Toxicological Sciences vol. 97 iss. 1 pp.214—221 Effects of Kava Alkaloid, Pipermethystine, and Kavalactones on Oxidative Stress and Cytochrome P450 in F-344 Rats DOI: 10.1093/toxsci/kfm035 a a	Lim, S. T.S.; Dragull, K.; Tang, C.-S.; Bittenbender, H. C.; Efird, J. T.; Nerurkar, P. V.		2007 May 01		English
	Planta Medica vol. 80 iss. 12 pp.1001—1008 Kavalactones, A Novel Class of Protein Glycation and Lipid Peroxidation Inhibitors DOI: 10.1055/s-0034-1382949 a a	Upadhyay, Atul; Tuenter, Emmy; Ahmad, Rizwan; Amin, Adnan; Exarchou, Vasiliki; Apers, Sandra; Hermans, Nina;[...]		2014 August 06		German;English
	Planta Medica vol. 68 iss. 12 pp.1055—1058 Inhibition of Cytochrome P450 3A4 by Extracts and Kavalactones of Piper methysticum (Kava-Kava) DOI: 10.1055/s-2002-36360 a a	Unger, Matthias; Holzgrabe, Ulrike; Jacobsen, Wolfgang; Cummins, Carolyn; Benet, Leslie Z.		2002 Dezember		German;English
	Planta Medica vol. 68 iss. 12 pp.1092—1096 Kavalactones and Dihydrokavain Modulate GABAergic Activity in a Rat Gastric-Brainstem Preparation DOI: 10.1055/s-2002-36338 a a	Yuan, Chun-Su; Dey, Lucy; Wang, Anbao; Mehendale, Sangeeta; Xie, Jing-Tian; Aung, Han H.; Ang-Lee, Michael K.		2002 Dezember		German;English
	European Journal of Mass Spectrometry vol. 12 iss. 4 pp.223—233 Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation DOI: 10.1255/ejms.808 a a	Warburton, Emma; Bristow, Tony		2006 August
	Biological & Pharmaceutical Bulletin vol. 29 iss. 4 pp.834—837 Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones DOI: 10.1248/bpb.29.834 a a	Matsuda, Hideaki; Hirata, Noriko; Kawaguchi, Yoshiko; Naruto, Shunsuke; Takata, Takanobu; Oyama, Masayoshi;[...]		2006		English
	Journal of Experimental Neuroscience vol. 11 pp.117906951770538 A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Transmission DOI: 10.1177/1179069517705384 a a	Kautu, Bwarenaba B; Phillips, Juliana; Steele, Kellie; Mengarelli, M Shawn; Nord, Eric A

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Organic Letters vol. 11 iss. 16 pp.3642—3645 Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones DOI: 10.1021/ol901416e a a	Moro, Angélica Venturini; Cardoso, Flávio Sega Pereira; Correia, Carlos Roque Duarte		2009 August 20		English
	Journal of Food Science and Technology vol. 52 iss. 2 pp.1164—1169 Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents DOI: 10.1007/s13197-013-1047-2 a a	Wang, Jun; Qu, Weiyue; Bittenbender, Harry C.; Li, Qing X.		2013 June 25		English
	Drug Metabolism and Disposition vol. 30 iss. 11 pp.1153—1157 Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones DOI: 10.1124/dmd.30.11.1153 a a	Mathews, J. M.		2002 November 01		English
	Journal of Agricultural and Food Chemistry vol. 56 iss. 13 pp.4976—4981 Quantification of Kavalactones and Determination of Kava (Piper methysticum) Chemotypes Using Near-Infrared Reflectance Spectroscopy for Quality Control in Vanuatu DOI: 10.1021/jf800439g a a	Lasme, Privat; Davrieux, Fabrice; Montet, Didier; Lebot, Vincent		2008 July		English
	Journal of Agricultural and Food Chemistry vol. 54 iss. 17 pp.6147—6152 Determination of Kavalactones in Dried Kava ( Piper methysticum ) Powder Using Near-Infrared Reflectance Spectroscopy and Partial Least-Squares Regression DOI: 10.1021/jf060964v a a	Gautz, Loren D.; Kaufusi, Pakieli; Jackson, Mel C.; Bittenbender, Harry C.; Tang, Chung-Shih		2006 August		English
	Organic Letters vol. 6 iss. 14 pp.2317—2320 Versatile Asymmetric Synthesis of the Kavalactones:  First Synthesis of (+)-Kavain DOI: 10.1021/ol0493960 a a	Smith, Thomas E.; Djang, Mabel; Velander, Alan J.; Downey, C. Wade; Carroll, Kathleen A.; van Alphen, Sophie		2004 July		English
	Analytical Methods vol. 2 iss. 5 pp.492 Rapid determination of six kavalactones in kava root and rhizome samples using Fourier transform infrared spectroscopy and multivariate analysis in comparison with gas chromatography DOI: 10.1039/c0ay00021c a a	Wang, Jun; Qu, Weiyue; Jun, Soojin; Bittenbender, Harry C.; Li, Qing X.		2010		English
	Drug Development and Industrial Pharmacy vol. 23 iss. 12 pp.1223—1226 Selection of Kavalactones by Complexation of Kava Extract with Cyclodextrins DOI: 10.3109/03639049709146161 a a	Amdidouche-hussain, Didja; Levesque, Joel		1997 January		English
	Journal of Bioscience and Bioengineering vol. 118 iss. 6 pp.679—688 Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells DOI: 10.1016/j.jbiosc.2014.05.009 a a	Rao, Yerra Koteswara; Shih, Hui-Nung; Lee, Yi-Ching; Cheng, Wen-Tai; Hung, Hui-Chin; Wang, Huang-Chi;[...]		2014 December		English
	Toxicological Sciences vol. 124 iss. 2 pp.388—399 Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1 DOI: 10.1093/toxsci/kfr235 a a	Li, Y.; Mei, H.; Wu, Q.; Zhang, S.; Fang, J.-L.; Shi, L.; Guo, L.		2011 September 09		English
	Journal of Liquid Chromatography & Related Technologies vol. 28 iss. 11 pp.1703—1716 Application of High Speed Countercurrent Chromatography (HSCCC) to the Isolation of Kavalactones DOI: 10.1081/jlc-200060451 a a	Schäfer, Katrien; Winterhalter, Peter		2005 June		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.187—188 Response to Schmidt "Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory" DOI: 10.1089/10755530360623293 a a	Whitton, Peter A.		2003 April		English
	Drug Metabolism and Disposition vol. 32 iss. 11 pp.1317—1324 DESMETHOXYYANGONIN AND DIHYDROMETHYSTICIN ARE TWO MAJOR PHARMACOLOGICAL KAVALACTONES WITH MARKED ACTIVITY ON THE INDUCTION OF CYP3A23 DOI: 10.1124/dmd.104.000786 a a	Ma, Y.		2004 July 28		English
	Molecular Pharmacology vol. 73 iss. 6 pp.1785—1795 Kavalactones Protect Neural Cells against Amyloid Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation DOI: 10.1124/mol.107.042499 a a	Wruck, C. J.; Gotz, M. E.; Herdegen, T.; Varoga, D.; Brandenburg, L.-O.; Pufe, T.		2008 March 11		English
	Drug Metabolism and Disposition vol. 33 iss. 10 pp.1555—1563 PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO DOI: 10.1124/dmd.105.004317 a a	Mathews, J. M.		2005 July 20		English
	Toxicological Sciences vol. 79 iss. 1 pp.106—111 In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones DOI: 10.1093/toxsci/kfh067 a a	Nerurkar, P. V.		2004 January 21		English
	Drug Metabolism and Disposition vol. 33 iss. 11 pp.1580—1583 EXTRACTS AND KAVALACTONES OF PIPER METHYSTICUM G. FORST (KAVA-KAVA) INHIBIT P-GLYCOPROTEIN IN VITRO DOI: 10.1124/dmd.105.005892 a a	Weiss, J.		2005 July 28		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.183—187 Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory DOI: 10.1089/10755530360623284 a a	Schmidt, Mathias		2003 April		English
	Toxicological Sciences vol. 97 iss. 1 pp.214—221 Effects of Kava Alkaloid, Pipermethystine, and Kavalactones on Oxidative Stress and Cytochrome P450 in F-344 Rats DOI: 10.1093/toxsci/kfm035 a a	Lim, S. T.S.; Dragull, K.; Tang, C.-S.; Bittenbender, H. C.; Efird, J. T.; Nerurkar, P. V.		2007 May 01		English
	Planta Medica vol. 80 iss. 12 pp.1001—1008 Kavalactones, A Novel Class of Protein Glycation and Lipid Peroxidation Inhibitors DOI: 10.1055/s-0034-1382949 a a	Upadhyay, Atul; Tuenter, Emmy; Ahmad, Rizwan; Amin, Adnan; Exarchou, Vasiliki; Apers, Sandra; Hermans, Nina;[...]		2014 August 06		German;English
	Planta Medica vol. 68 iss. 12 pp.1055—1058 Inhibition of Cytochrome P450 3A4 by Extracts and Kavalactones of Piper methysticum (Kava-Kava) DOI: 10.1055/s-2002-36360 a a	Unger, Matthias; Holzgrabe, Ulrike; Jacobsen, Wolfgang; Cummins, Carolyn; Benet, Leslie Z.		2002 Dezember		German;English
	Planta Medica vol. 68 iss. 12 pp.1092—1096 Kavalactones and Dihydrokavain Modulate GABAergic Activity in a Rat Gastric-Brainstem Preparation DOI: 10.1055/s-2002-36338 a a	Yuan, Chun-Su; Dey, Lucy; Wang, Anbao; Mehendale, Sangeeta; Xie, Jing-Tian; Aung, Han H.; Ang-Lee, Michael K.		2002 Dezember		German;English
	European Journal of Mass Spectrometry vol. 12 iss. 4 pp.223—233 Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation DOI: 10.1255/ejms.808 a a	Warburton, Emma; Bristow, Tony		2006 August
	Biological & Pharmaceutical Bulletin vol. 29 iss. 4 pp.834—837 Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones DOI: 10.1248/bpb.29.834 a a	Matsuda, Hideaki; Hirata, Noriko; Kawaguchi, Yoshiko; Naruto, Shunsuke; Takata, Takanobu; Oyama, Masayoshi;[...]		2006		English
	Journal of Experimental Neuroscience vol. 11 pp.117906951770538 A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Transmission DOI: 10.1177/1179069517705384 a a	Kautu, Bwarenaba B; Phillips, Juliana; Steele, Kellie; Mengarelli, M Shawn; Nord, Eric A

The above are all hotlinks to the .PDF files of the papers named.

Thank you so much!

 

[RUC4]

I have trouble finding a good breakdown of the full pharmacology of kava. I have some very expensive reputed to be high quality heady kava coming in a day or two and have been trying to find a good breakdown of the pharmacology.

Are there any pros here that can break it down for me please?

I just recently bought some powdered Kava. I put it in a tea bag, but haven't tried it yet. I've had it many times at Kava/Kratom bars.

 

[RUC4]

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Annales de Toxicologie Analytique vol. 25 iss. 3 pp.109—119 Chromatographic hair analysis for natural kavalactones and their metabolites. A preliminary study DOI: 10.1051/ata/2013044 a a	Tarbah, Fuad ;Barguil, Yann ;Müller, Claudia ;Rickert, Annette ;Weinmann, Wolfgang ;Nour, Mohammed ;Kintz, Pascal ;[...]	EDP Sciences	2013 Novembre 07		French;English
	Planta Medica vol. 79 iss. 13 Kavalactones as inhibitors of advanced glycation endproducts (AGEs) formation DOI: 10.1055/s-0033-1352456 a a	Upadhyay, A ;Tuenter, E ;Ahmad, R ;Apers, S ;Hermans, N ;Pieters, L	Georg Thieme Verlag KG	2013 August 21		German;English
	The biosynthetic origin of psychoactive kavalactones in kava DOI: 10.1101/294439 posted-content l	Pluskal, Tomáš ;Torrens-Spence, Michael P. ;Fallon, Timothy R. ;De Abreu, Andrea ;Shi, Cindy H. ;Weng, Jing-Ke	Cold Spring Harbor Laboratory	2018 April 04
	Medicine Research vol. 2 iss. 1 pp.20170019—3 Plant-Derived Kavalactones and Their Bioactivities DOI: 10.21127/yaoyimr20170019 a a	Zhang, Nenling ;Wu, Linjing ;Liu, Xiang ;Shen, Xiangchun	Yaoyi International Publishing	2018
	BIO-PROTOCOL vol. 8 iss. 18 A Behavioral Assay to Examine the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Excitability DOI: 10.21769/bioprotoc.3008 a a	Kautu, Bwarenaba ;Chappel, Jessie ;Steele, Kellie ;Phillips, Juliana ;Mengarelli, M.	Bio-Protocol, LLC	2018
	Neural Regeneration Research vol. 10 iss. 6 pp.875 Neuroprotective properties of kavalactones DOI: 10.4103/1673-5374.158335 a a	Lee, Meng-Jen ;Tzeng, Yew-Min	Medknow	2015		English
	ChemInform vol. 35 iss. 45 pp.0—0 Versatile Asymmetric Synthesis of the Kavalactones: First Synthesis of (+)-Kavain. DOI: 10.1002/chin.200445231 a a	Thomas E. Smith; Mabel Djang; Alan J. Velander; C. Wade Downey; Kathleen A. Carroll; Sophie van Alphen		2004 November 09
	ChemInform vol. 41 iss. 2 pp.0—0 ChemInform Abstract: Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones. DOI: 10.1002/chin.201002079 a a	Angelica Venturini Moro; Flavio Sega Pereira Cardoso; Carlos Roque Duarte Correia		2010 January 12
	Analytica Chimica Acta vol. 501 iss. 2 pp.175—181 Pressurized fluid extraction of carotenoids from Haematococcus pluvialis and Dunaliella salina and kavalactones from Piper methysticum DOI: 10.1016/j.aca.2003.09.026 a a	Judith R Denery; Klaus Dragull; C.S Tang; Qing X Li		2004 January		English;French;German
	Journal of Chromatography B vol. 812 iss. 1-2 pp.203—214 Analysis of kavalactones from Piper methysticum (kava-kava) DOI: 10.1016/j.jchromb.2004.07.038 a a	Anna Rita Bilia; Luca Scalise; Maria Camilla Bergonzi; Franco F. Vincieri		2004		English
	Journal of Pharmaceutical and Biomedical Analysis vol. 52 iss. 4 pp.479—483 Cyclodextrins as carriers for kavalactones in aqueous media: Spectroscopic characterization of (S)-7,8-dihydrokavain and β-cyclodextrin inclusion complex DOI: 10.1016/j.jpba.2010.01.037 a a	G. Pescitelli; A.R. Bilia; M.C. Bergonzi; F.F. Vincieri; L. Di Bari		2010 August		English
	Tetrahedron Letters vol. 47 iss. 49 pp.8657—8660 Chemoenzymatic synthesis of enantiomerically enriched kavalactones DOI: 10.1016/j.tetlet.2006.09.155 a a	Ahmed Kamal; Tadiparthi Krishnaji; G.B. Ramesh Khanna		2006 Décembre		French;German;English
	Journal of Chromatography A vol. 825 iss. 1 pp.1—8 Reversed-phase high-performance liquid chromatographic method for quantitative analysis of the six major kavalactones in Piper methysticum DOI: 10.1016/s0021-9673(98)00699-2 a a	Yu Shao; Kan He; Bolin Zheng; Qunyi Zheng		1998 October		English
	Journal of Chromatography A vol. 848 iss. 1-2 pp.457—464 Qualitative and quantitative micellar electrokinetic chromatography of kavalactones from dry extracts of Piper methysticum Forst. and commercial drugs DOI: 10.1016/s0021-9673(99)00425-2 a a	Matthias Lechtenberg; Bettina Quandt; Franz-Josef Kohlenberg; Adolf Nahrstedt		1999 July		English
	Phytochemistry vol. 59 iss. 4 pp.429—433 Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses DOI: 10.1016/s0031-9422(01)00443-5 a a	H Ranjith W. Dharmaratne; N.P Dhammika Nanayakkara; Ikhlas A Khan		2002 February		English
	Phytochemical Analysis vol. 18 iss. 2 pp.98—102 Comparison of the capabilities of accelerated solvent extraction and sonication as extraction techniques for the quantification of kavalactones in piper methysticum (Kava) roots by high performance liquid chromatography with ultra violet detection DOI: 10.1002/pca.955 a a	Emma Warburton; Paul L Norris; Heidi Goenaga-Infante		2007 March		English
	Phytotherapy Research vol. 25 iss. 3 pp.n/a—n/a Kavalactones Yangonin and Methysticin Induce Apoptosis in Human Hepatocytes (HepG2) In Vitro DOI: 10.1002/ptr.3283 a a	J. Tang; R. A. Dunlop; A. Rowe; K. J. Rodgers; I. Ramzan		2010 August 23		English
	Psychopharmacology vol. 155 iss. 1 pp.86—90 Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm DOI: 10.1007/s002130100686 a a	Kenyatta K. Smith; H. Ranjith W. Dharmaratne; Matt W. Feltenstein; Susan L. Broom; J. Todd Roach; N.P. Dhammika Nanayakkara;[...]		2001 March 15		English
	Journal of Clinical Pharmacy and Therapeutics vol. 32 iss. 3 pp.233—239 Permeability studies of Kavalactones using a Caco-2 cell monolayer model DOI: 10.1111/j.1365-2710.2007.00810.x a a	A. Matthias; J. T. Blanchfield; K. G. Penman; K. M. Bone; I. Toth; R. P. Lehmann		2007 June		English
	Journal of Food Science vol. 71 iss. 6 pp.C345—C351 Assessment of Kavalactones in Kava Beverage Products and Aqueous Infusions DOI: 10.1111/j.1750-3841.2006.00102.x a a	J.-W. Jhoo; J. P. Freeman; C. Y. W. Ang; J. J. Mihalov		2006 August		English
	European Journal of Organic Chemistry vol. 2012 iss. 19 pp.3607—3616 Heck–Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues DOI: 10.1002/ejoc.201200308 a a	Cristian Soldi; Angélica V. Moro; Moacir G. Pizzolatti; Carlos R. D. Correia		2012 May 22		English
	Phytotherapy Research vol. 26 iss. 12 pp.1934—1941 Pacific Island 'Awa (Kava) Extracts, but not Isolated Kavalactones, Promote Proinflammatory Responses in Model Mast Cells DOI: 10.1002/ptr.4652 a a	Lori M. N. Shimoda; Christy Park; Alexander J. Stokes; Henry Halenani Gomes; Helen Turner		2012 April 04		English
	Phytomedicine vol. 13 iss. 3 pp.192—195 Kavalactones fail to inhibit alcohol dehydrogenase in vitro DOI: 10.1016/j.phymed.2004.07.005 a a	J. Anke; S. Fu; I. Ramzan		2006 February		English
	ChemInform vol. 43 iss. 48 pp.no—no ChemInform Abstract: Heck-Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues. DOI: 10.1002/chin.201248136 a a	Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D.		2012 November 08
	Pharmacological Research vol. 66 iss. 2 pp.163—169 Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB1 receptor ligand DOI: 10.1016/j.phrs.2012.04.003 a a

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Organic Letters vol. 11 iss. 16 pp.3642—3645 Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones DOI: 10.1021/ol901416e a a	Moro, Angélica Venturini; Cardoso, Flávio Sega Pereira; Correia, Carlos Roque Duarte		2009 August 20		English
	Journal of Food Science and Technology vol. 52 iss. 2 pp.1164—1169 Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents DOI: 10.1007/s13197-013-1047-2 a a	Wang, Jun; Qu, Weiyue; Bittenbender, Harry C.; Li, Qing X.		2013 June 25		English
	Drug Metabolism and Disposition vol. 30 iss. 11 pp.1153—1157 Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones DOI: 10.1124/dmd.30.11.1153 a a	Mathews, J. M.		2002 November 01		English
	Journal of Agricultural and Food Chemistry vol. 56 iss. 13 pp.4976—4981 Quantification of Kavalactones and Determination of Kava (Piper methysticum) Chemotypes Using Near-Infrared Reflectance Spectroscopy for Quality Control in Vanuatu DOI: 10.1021/jf800439g a a	Lasme, Privat; Davrieux, Fabrice; Montet, Didier; Lebot, Vincent		2008 July		English
	Journal of Agricultural and Food Chemistry vol. 54 iss. 17 pp.6147—6152 Determination of Kavalactones in Dried Kava ( Piper methysticum ) Powder Using Near-Infrared Reflectance Spectroscopy and Partial Least-Squares Regression DOI: 10.1021/jf060964v a a	Gautz, Loren D.; Kaufusi, Pakieli; Jackson, Mel C.; Bittenbender, Harry C.; Tang, Chung-Shih		2006 August		English
	Organic Letters vol. 6 iss. 14 pp.2317—2320 Versatile Asymmetric Synthesis of the Kavalactones:  First Synthesis of (+)-Kavain DOI: 10.1021/ol0493960 a a	Smith, Thomas E.; Djang, Mabel; Velander, Alan J.; Downey, C. Wade; Carroll, Kathleen A.; van Alphen, Sophie		2004 July		English
	Analytical Methods vol. 2 iss. 5 pp.492 Rapid determination of six kavalactones in kava root and rhizome samples using Fourier transform infrared spectroscopy and multivariate analysis in comparison with gas chromatography DOI: 10.1039/c0ay00021c a a	Wang, Jun; Qu, Weiyue; Jun, Soojin; Bittenbender, Harry C.; Li, Qing X.		2010		English
	Drug Development and Industrial Pharmacy vol. 23 iss. 12 pp.1223—1226 Selection of Kavalactones by Complexation of Kava Extract with Cyclodextrins DOI: 10.3109/03639049709146161 a a	Amdidouche-hussain, Didja; Levesque, Joel		1997 January		English
	Journal of Bioscience and Bioengineering vol. 118 iss. 6 pp.679—688 Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells DOI: 10.1016/j.jbiosc.2014.05.009 a a	Rao, Yerra Koteswara; Shih, Hui-Nung; Lee, Yi-Ching; Cheng, Wen-Tai; Hung, Hui-Chin; Wang, Huang-Chi;[...]		2014 December		English
	Toxicological Sciences vol. 124 iss. 2 pp.388—399 Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1 DOI: 10.1093/toxsci/kfr235 a a	Li, Y.; Mei, H.; Wu, Q.; Zhang, S.; Fang, J.-L.; Shi, L.; Guo, L.		2011 September 09		English
	Journal of Liquid Chromatography & Related Technologies vol. 28 iss. 11 pp.1703—1716 Application of High Speed Countercurrent Chromatography (HSCCC) to the Isolation of Kavalactones DOI: 10.1081/jlc-200060451 a a	Schäfer, Katrien; Winterhalter, Peter		2005 June		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.187—188 Response to Schmidt "Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory" DOI: 10.1089/10755530360623293 a a	Whitton, Peter A.		2003 April		English
	Drug Metabolism and Disposition vol. 32 iss. 11 pp.1317—1324 DESMETHOXYYANGONIN AND DIHYDROMETHYSTICIN ARE TWO MAJOR PHARMACOLOGICAL KAVALACTONES WITH MARKED ACTIVITY ON THE INDUCTION OF CYP3A23 DOI: 10.1124/dmd.104.000786 a a	Ma, Y.		2004 July 28		English
	Molecular Pharmacology vol. 73 iss. 6 pp.1785—1795 Kavalactones Protect Neural Cells against Amyloid Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation DOI: 10.1124/mol.107.042499 a a	Wruck, C. J.; Gotz, M. E.; Herdegen, T.; Varoga, D.; Brandenburg, L.-O.; Pufe, T.		2008 March 11		English
	Drug Metabolism and Disposition vol. 33 iss. 10 pp.1555—1563 PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO DOI: 10.1124/dmd.105.004317 a a	Mathews, J. M.		2005 July 20		English
	Toxicological Sciences vol. 79 iss. 1 pp.106—111 In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones DOI: 10.1093/toxsci/kfh067 a a	Nerurkar, P. V.		2004 January 21		English
	Drug Metabolism and Disposition vol. 33 iss. 11 pp.1580—1583 EXTRACTS AND KAVALACTONES OF PIPER METHYSTICUM G. FORST (KAVA-KAVA) INHIBIT P-GLYCOPROTEIN IN VITRO DOI: 10.1124/dmd.105.005892 a a	Weiss, J.		2005 July 28		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.183—187 Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory DOI: 10.1089/10755530360623284 a a	Schmidt, Mathias		2003 April		English
	Toxicological Sciences vol. 97 iss. 1 pp.214—221 Effects of Kava Alkaloid, Pipermethystine, and Kavalactones on Oxidative Stress and Cytochrome P450 in F-344 Rats DOI: 10.1093/toxsci/kfm035 a a	Lim, S. T.S.; Dragull, K.; Tang, C.-S.; Bittenbender, H. C.; Efird, J. T.; Nerurkar, P. V.		2007 May 01		English
	Planta Medica vol. 80 iss. 12 pp.1001—1008 Kavalactones, A Novel Class of Protein Glycation and Lipid Peroxidation Inhibitors DOI: 10.1055/s-0034-1382949 a a	Upadhyay, Atul; Tuenter, Emmy; Ahmad, Rizwan; Amin, Adnan; Exarchou, Vasiliki; Apers, Sandra; Hermans, Nina;[...]		2014 August 06		German;English
	Planta Medica vol. 68 iss. 12 pp.1055—1058 Inhibition of Cytochrome P450 3A4 by Extracts and Kavalactones of Piper methysticum (Kava-Kava) DOI: 10.1055/s-2002-36360 a a	Unger, Matthias; Holzgrabe, Ulrike; Jacobsen, Wolfgang; Cummins, Carolyn; Benet, Leslie Z.		2002 Dezember		German;English
	Planta Medica vol. 68 iss. 12 pp.1092—1096 Kavalactones and Dihydrokavain Modulate GABAergic Activity in a Rat Gastric-Brainstem Preparation DOI: 10.1055/s-2002-36338 a a	Yuan, Chun-Su; Dey, Lucy; Wang, Anbao; Mehendale, Sangeeta; Xie, Jing-Tian; Aung, Han H.; Ang-Lee, Michael K.		2002 Dezember		German;English
	European Journal of Mass Spectrometry vol. 12 iss. 4 pp.223—233 Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation DOI: 10.1255/ejms.808 a a	Warburton, Emma; Bristow, Tony		2006 August
	Biological & Pharmaceutical Bulletin vol. 29 iss. 4 pp.834—837 Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones DOI: 10.1248/bpb.29.834 a a	Matsuda, Hideaki; Hirata, Noriko; Kawaguchi, Yoshiko; Naruto, Shunsuke; Takata, Takanobu; Oyama, Masayoshi;[...]		2006		English
	Journal of Experimental Neuroscience vol. 11 pp.117906951770538 A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Transmission DOI: 10.1177/1179069517705384 a a	Kautu, Bwarenaba B; Phillips, Juliana; Steele, Kellie; Mengarelli, M Shawn; Nord, Eric A

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Organic Letters vol. 11 iss. 16 pp.3642—3645 Highly Regio- and Stereoselective Heck Reaction of Allylic Esters with Arenediazonium Salts: Application to the Synthesis of Kavalactones DOI: 10.1021/ol901416e a a	Moro, Angélica Venturini; Cardoso, Flávio Sega Pereira; Correia, Carlos Roque Duarte		2009 August 20		English
	Journal of Food Science and Technology vol. 52 iss. 2 pp.1164—1169 Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents DOI: 10.1007/s13197-013-1047-2 a a	Wang, Jun; Qu, Weiyue; Bittenbender, Harry C.; Li, Qing X.		2013 June 25		English
	Drug Metabolism and Disposition vol. 30 iss. 11 pp.1153—1157 Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones DOI: 10.1124/dmd.30.11.1153 a a	Mathews, J. M.		2002 November 01		English
	Journal of Agricultural and Food Chemistry vol. 56 iss. 13 pp.4976—4981 Quantification of Kavalactones and Determination of Kava (Piper methysticum) Chemotypes Using Near-Infrared Reflectance Spectroscopy for Quality Control in Vanuatu DOI: 10.1021/jf800439g a a	Lasme, Privat; Davrieux, Fabrice; Montet, Didier; Lebot, Vincent		2008 July		English
	Journal of Agricultural and Food Chemistry vol. 54 iss. 17 pp.6147—6152 Determination of Kavalactones in Dried Kava ( Piper methysticum ) Powder Using Near-Infrared Reflectance Spectroscopy and Partial Least-Squares Regression DOI: 10.1021/jf060964v a a	Gautz, Loren D.; Kaufusi, Pakieli; Jackson, Mel C.; Bittenbender, Harry C.; Tang, Chung-Shih		2006 August		English
	Organic Letters vol. 6 iss. 14 pp.2317—2320 Versatile Asymmetric Synthesis of the Kavalactones:  First Synthesis of (+)-Kavain DOI: 10.1021/ol0493960 a a	Smith, Thomas E.; Djang, Mabel; Velander, Alan J.; Downey, C. Wade; Carroll, Kathleen A.; van Alphen, Sophie		2004 July		English
	Analytical Methods vol. 2 iss. 5 pp.492 Rapid determination of six kavalactones in kava root and rhizome samples using Fourier transform infrared spectroscopy and multivariate analysis in comparison with gas chromatography DOI: 10.1039/c0ay00021c a a	Wang, Jun; Qu, Weiyue; Jun, Soojin; Bittenbender, Harry C.; Li, Qing X.		2010		English
	Drug Development and Industrial Pharmacy vol. 23 iss. 12 pp.1223—1226 Selection of Kavalactones by Complexation of Kava Extract with Cyclodextrins DOI: 10.3109/03639049709146161 a a	Amdidouche-hussain, Didja; Levesque, Joel		1997 January		English
	Journal of Bioscience and Bioengineering vol. 118 iss. 6 pp.679—688 Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells DOI: 10.1016/j.jbiosc.2014.05.009 a a	Rao, Yerra Koteswara; Shih, Hui-Nung; Lee, Yi-Ching; Cheng, Wen-Tai; Hung, Hui-Chin; Wang, Huang-Chi;[...]		2014 December		English
	Toxicological Sciences vol. 124 iss. 2 pp.388—399 Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1 DOI: 10.1093/toxsci/kfr235 a a	Li, Y.; Mei, H.; Wu, Q.; Zhang, S.; Fang, J.-L.; Shi, L.; Guo, L.		2011 September 09		English
	Journal of Liquid Chromatography & Related Technologies vol. 28 iss. 11 pp.1703—1716 Application of High Speed Countercurrent Chromatography (HSCCC) to the Isolation of Kavalactones DOI: 10.1081/jlc-200060451 a a	Schäfer, Katrien; Winterhalter, Peter		2005 June		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.187—188 Response to Schmidt "Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory" DOI: 10.1089/10755530360623293 a a	Whitton, Peter A.		2003 April		English
	Drug Metabolism and Disposition vol. 32 iss. 11 pp.1317—1324 DESMETHOXYYANGONIN AND DIHYDROMETHYSTICIN ARE TWO MAJOR PHARMACOLOGICAL KAVALACTONES WITH MARKED ACTIVITY ON THE INDUCTION OF CYP3A23 DOI: 10.1124/dmd.104.000786 a a	Ma, Y.		2004 July 28		English
	Molecular Pharmacology vol. 73 iss. 6 pp.1785—1795 Kavalactones Protect Neural Cells against Amyloid Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation DOI: 10.1124/mol.107.042499 a a	Wruck, C. J.; Gotz, M. E.; Herdegen, T.; Varoga, D.; Brandenburg, L.-O.; Pufe, T.		2008 March 11		English
	Drug Metabolism and Disposition vol. 33 iss. 10 pp.1555—1563 PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO DOI: 10.1124/dmd.105.004317 a a	Mathews, J. M.		2005 July 20		English
	Toxicological Sciences vol. 79 iss. 1 pp.106—111 In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones DOI: 10.1093/toxsci/kfh067 a a	Nerurkar, P. V.		2004 January 21		English
	Drug Metabolism and Disposition vol. 33 iss. 11 pp.1580—1583 EXTRACTS AND KAVALACTONES OF PIPER METHYSTICUM G. FORST (KAVA-KAVA) INHIBIT P-GLYCOPROTEIN IN VITRO DOI: 10.1124/dmd.105.005892 a a	Weiss, J.		2005 July 28		English
	Journal of Alternative and Complementary Medicine vol. 9 iss. 2 pp.183—187 Are Kavalactones the Hepatotoxic Principle of Kava Extracts? The Pitfalls of the Glutathione Theory DOI: 10.1089/10755530360623284 a a	Schmidt, Mathias		2003 April		English
	Toxicological Sciences vol. 97 iss. 1 pp.214—221 Effects of Kava Alkaloid, Pipermethystine, and Kavalactones on Oxidative Stress and Cytochrome P450 in F-344 Rats DOI: 10.1093/toxsci/kfm035 a a	Lim, S. T.S.; Dragull, K.; Tang, C.-S.; Bittenbender, H. C.; Efird, J. T.; Nerurkar, P. V.		2007 May 01		English
	Planta Medica vol. 80 iss. 12 pp.1001—1008 Kavalactones, A Novel Class of Protein Glycation and Lipid Peroxidation Inhibitors DOI: 10.1055/s-0034-1382949 a a	Upadhyay, Atul; Tuenter, Emmy; Ahmad, Rizwan; Amin, Adnan; Exarchou, Vasiliki; Apers, Sandra; Hermans, Nina;[...]		2014 August 06		German;English
	Planta Medica vol. 68 iss. 12 pp.1055—1058 Inhibition of Cytochrome P450 3A4 by Extracts and Kavalactones of Piper methysticum (Kava-Kava) DOI: 10.1055/s-2002-36360 a a	Unger, Matthias; Holzgrabe, Ulrike; Jacobsen, Wolfgang; Cummins, Carolyn; Benet, Leslie Z.		2002 Dezember		German;English
	Planta Medica vol. 68 iss. 12 pp.1092—1096 Kavalactones and Dihydrokavain Modulate GABAergic Activity in a Rat Gastric-Brainstem Preparation DOI: 10.1055/s-2002-36338 a a	Yuan, Chun-Su; Dey, Lucy; Wang, Anbao; Mehendale, Sangeeta; Xie, Jing-Tian; Aung, Han H.; Ang-Lee, Michael K.		2002 Dezember		German;English
	European Journal of Mass Spectrometry vol. 12 iss. 4 pp.223—233 Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation DOI: 10.1255/ejms.808 a a	Warburton, Emma; Bristow, Tony		2006 August
	Biological & Pharmaceutical Bulletin vol. 29 iss. 4 pp.834—837 Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones DOI: 10.1248/bpb.29.834 a a	Matsuda, Hideaki; Hirata, Noriko; Kawaguchi, Yoshiko; Naruto, Shunsuke; Takata, Takanobu; Oyama, Masayoshi;[...]		2006		English
	Journal of Experimental Neuroscience vol. 11 pp.117906951770538 A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Transmission DOI: 10.1177/1179069517705384 a a	Kautu, Bwarenaba B; Phillips, Juliana; Steele, Kellie; Mengarelli, M Shawn; Nord, Eric A

The above are all hotlinks to the .PDF files of the papers named.

Did you compile this list just for this post? What an amazing list.

 

[AlsoTapered]

Yeah, 2 minutes well spent, I reckon.

I'm not going to READ them all, I have over 450,000 papers to get through before this.

 

[RUC4]

Yeah, 2 minutes well spent, I reckon.

I'm not going to READ them all, I have over 450,000 papers to get through before this.

Can I ask why?

 

[AlsoTapered]

There are only so many baths one can usefully take in one day.