I quit using my clonazepam albeit it wasn’t as ordered. I’m quitting now again with just a simple anxiety replacement (Fiornal with Codeine lmao). I don’t really think it has that much of a withdrawal from some. If it’s a calcium channel blocker, and just mimics gaba. I doubt unless you’ve used for years it being that physically bad. But I’m on day 2 without it and I just found 300mg
Honestly it’s probably being overblown by both parties. My doctor claims in normal dosages, and not preg. It can be discontinued whenever up to 2400/2700mg Daily. If you get a script of opiates, be thankful. I wouldn’t fuck that up cause you never said if you got pill counts, besides since your prescribed. I doubt opiates would do anything beyond bring you back to baseline now, endorphins. Hell even oxy would only release serotonin and dopamine not block calcium channels. Will you possibly feel like shit you might. But you might find you can come and go as you please.
Rather eat half my benzos in a weekend. Regretting now.
Effecting and replacement is two different things. Even with benzos what people forget is that unlike opiates or stims. There’s only so much benzo you can squeeze into the receptor I find sometimes lighter doses to be more effective then higher doses of both gaba/clonazIt’s not accurate to say it doesn’t affect GABA at all.
“In vitro, gabapentin modulates the action of the GABA synthetic enzyme, glutamic acid decarboxylase (GAD) and the glutamate synthesizing enzyme, branched-chain amino acid transaminase. Results with human and rat brain NMR spectroscopy indicate that gabapentin increases GABA synthesis.”
Mechanisms of action of gabapentin - PubMed
The chemical structure of gabapentin (Neurontin) is derived by addition of a cyclohexyl group to the backbone of gamma-aminobutyric acid (GABA). Gabapentin prevents seizures in a wide variety of models in animals, including generalized tonic-clonic and partial seizures. Gabapentin has no...pubmed.ncbi.nlm.nih.gov
I mean. Do you think I’ve been to prideful not to go up there and basically admit I ate all my clonazepam lmao, beats begging a doc. But that was years ago. Neuropathy is one thing I can’t talk about then. I take for anxiety. A good kicker is 2400mg for me. But I’m getting to where I take drug holidays on all my CS meds. I assume gaba is a CS in my state as I have to provide ID.
.
I’m about like this. Luckily I got fiornal lmao. My addy script is due Friday. My plug comes through on the
and oxy tomorrow. So I’ve skated by on another month, no gaba and a week from getting my clonazepam although I always save 3 1mg for emergencies.
I mean. Do you think I’ve been to prideful not to go up there and basically admit I ate all my clonazepam lmao, beats begging a doc. But that was years ago. Neuropathy is one thing I can’t talk about then. I take for anxiety. A good kicker is 2400mg for me. But I’m getting to where I take drug holidays on all my CS meds. I assume gaba is a CS in my state as I have to provide ID.
I do admit to constantly switching between drugs, I found though if you can perhaps get some Addie’s. They adderall for me works as a pain reliever/anxiety/depression me. It really shouldn’t be as it’s the most expensive med I fill, But even paying outta pocket perhaps could help. They are bitches about filling my gaba. But will fill a benzo script helluh early. Cash still is king
But depending on opioid dosage. I would hate to be in a predicament I’m sick without my meds. Especially the bathroom bound side effects give you, but gaba is a dime a dozen. I’d just suggest you increase your meds. Or possibly talk to doc about lyrica if unmanaged. Despite that increasing w/d and seizure issues.
Because I’m being fair. In my Rec usage I get treated now, with all the cutbacks to 50mg oxy maybe 2 times a week. If I combine that with 2400mg gaba after a week or two break from gaba. I’m pretty sure I’d die.
Lol probably not as I’ve used opiates since a kid, and gaba for about a year. Both pretty frequently. I wouldn’t do anything that causes an eyebrow to get raised (ie subbing opies for gabapentin). Imo the only sub is benzos and even then your kinda mortgaging the farm to pay for the car.
No
I’m about like this. Luckily I got fiornal lmao. My addy script is due Friday. My plug comes through on the
No
I’m about like this. Luckily I got fiornal lmao. My addy script is due Friday. My plug comes through on the
Waste of gaba indeed.
I don't think that's a reason to be happy seriously....poor liver and kidneys have to process all thst shit errrday...I'm in the UK, bitch. ALL my meds are free! Muahahahahah. And I'm on 14 of them
Once my wish was to get prescription-free access to a pharmacy but now I have kind of, in the past a doc prescribing the harder things like lisdexamphetamine, morphine etc. and now here most non-narcotics are cheap and OTC but I soon realized that the good stuff isn't available out of pharmacies at all and now I want to educate myself enough in chemistry to being able to synth my stuff myself. Pharmaceutical drugs suck.
Well there are different categories of work. They are built to process all sort of stuff from food, and there are drugs which don't (seem) to harm the organs, for example pregabalin gets excreted unmetabolized, or morphine* or low dose amphetamine** where they say you could take it for decades without physical injury. Opposite are nasty drugs like many of the antiepileptics/"mood stabilizers" that have black box warnings and require regular blood checks (which most docs neglect). Valproic acid is one of them. The good drugs which MIGHT harm the organs have been pulled, like pemoline, Kava (in the EU), but the bad ones which DO hurt are still partially OTC (paracetamol, said valproate, I forgot but there are quite a bunch of others). Then we have the interactions, stuff like fluoxetine which is a potent CYP2D6 inhibitor, this seems to be pretty unproblematic but just take a drug which is primarily metabolized by 2D6 and then gets metabolized into something else, and that something else be toxic. Few drugs have actually been studied in a multi-drug 'setting', and most also only over a few months (SSRIs being an infamous example, when taken for too long they make one dependent, it is WORSE than morphine for me to quit them. Currently not possible..Yeshhh, WORK FASTER LIVER. METABOLIZE MY MORPHINE FASTER, U C*NT!!!!!!☠✌
)
Yeshhh, WORK FASTER LIVER. METABOLIZE MY MORPHINE FASTER, U C*NT!!!!!!
It’s not accurate to say it doesn’t affect GABA at all.
“In vitro, gabapentin modulates the action of the GABA synthetic enzyme, glutamic acid decarboxylase (GAD) and the glutamate synthesizing enzyme, branched-chain amino acid transaminase. Results with human and rat brain NMR spectroscopy indicate that gabapentin increases GABA synthesis.”
Mechanisms of action of gabapentin - PubMed
The chemical structure of gabapentin (Neurontin) is derived by addition of a cyclohexyl group to the backbone of gamma-aminobutyric acid (GABA). Gabapentin prevents seizures in a wide variety of models in animals, including generalized tonic-clonic and partial seizures. Gabapentin has no...
