JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,468
Might be a silly question - but perhaps the more knowledgeable can give insight, cause I got nothing on this.
The mix is - Mianserin (mirtazapine analogue), desipramine, reboxetine.
Desipramine is one 1/3rd the full dose.
Mianserin, 2/3rds the full dose.
Reboxetine, 1/3rd the full dose.
It's the combination of two NRI's in reboxetine and desipramine that is of concern.
There are no enzyme inhibitions of one to the other that raise plasma levels etc.
But - without the reboxetine, I was okay.
I added 2 mg rebox - and that was okay.
I upped it to four - and on the fourth day, fatigue hit.
To much noradrenaline?
Or a potential combination of desipramine and reboxetine that gives rise to it?
My concern was - on higher levels of desipramine - fatigue was also an issue.
Actually, fatigue with anxiety - like akathisia.
But, being a tricyclic, fatigue is common.
Fatigue plus activation via noradrenaline.
So - reboxetine, fatigue is not common.
Which is why I'm trying to determine how it's addition, with the other two - resulted in it.
The mix is - Mianserin (mirtazapine analogue), desipramine, reboxetine.
Desipramine is one 1/3rd the full dose.
Mianserin, 2/3rds the full dose.
Reboxetine, 1/3rd the full dose.
It's the combination of two NRI's in reboxetine and desipramine that is of concern.
There are no enzyme inhibitions of one to the other that raise plasma levels etc.
But - without the reboxetine, I was okay.
I added 2 mg rebox - and that was okay.
I upped it to four - and on the fourth day, fatigue hit.
To much noradrenaline?
Or a potential combination of desipramine and reboxetine that gives rise to it?
My concern was - on higher levels of desipramine - fatigue was also an issue.
Actually, fatigue with anxiety - like akathisia.
But, being a tricyclic, fatigue is common.
Fatigue plus activation via noradrenaline.
So - reboxetine, fatigue is not common.
Which is why I'm trying to determine how it's addition, with the other two - resulted in it.