Relevant story......12mg 2C-E camping in the Colorado wilderness with a friend. 6hr in or so, past the peak but still tripping hard, I was trying to position my (well heated) propane powered catalytic heater and looked down to notice I had burned off all the flesh on my hand, exposing whatever you call the red stuff underneath, because I was a tripping idiot and wasn't paying attention. Fear, then crying like a baby, then I stopped to realize there was no pain at all. It literally did not hurt and never did the entire rest of the evening...nor oddly enough did it hurt the next day...a smarter man than I would have gone to the hospital the next day but I didn't and it healed without incident or a scar.