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Can ecstasy decrease the effects of magic mushrooms and LSD.

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austins312

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Joined
Aug 19, 2011
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9
Think about it, ecstasy releases serotonin, and magic mushrooms and LSD bind to serotonin right so could taking MDMA decrease the effects of magic mushrooms and LSD?
 
I have never tried flipping before but I've never heard anything about a reduced trip or roll from those combos.
However, heard that both combos will give you one hell of a night.
I plan on candyflipping for new years, I'll be sure to let you know if I feel a difference.
 
i know that when i roll balls or taking a lot of mdma and take an ambien i hallucinate like crazy, although im not sure about lsd and shrooms i can only assume the same will happen
 
Change =Yes - 'decrease' is down to the individual?

Too wasted to go much deeper into the subject :)
 
1 Pink Diamond (90mg) was enough to kick out 100 liberty caps in a tea. Went from tripping my bollocks off to being cunted on md, no shroom buzz, in about 30 seconds.
 
Mushrooms and LSD are both 5-HT2a agonists.
Of all serotonin receptors, which there are many, the 2a is most associated with the euphoria and hallucinations of psychedelic drugs.

And MDMA, as a potent releaser and agonist...
Actually causes a LOSS of 5-HT2a receptors, especially in the precious Prefrontal Cortex (highest cognitive center).

Former MDMA users that have undergone imaging have displayed loss of serotonin and 2a receptor density in the frontal lobes.
Even long into abstinence...2 years or more.
And it is presumed that although recovery may continue, original density will be forever lost in these people.

Current users almost ALWAYS show a loss of function, which could be caused by the transient effects of the drug.
But a portion of abstinent users go on to retain this loss for many years, suggesting definitive neurotoxic effects.
So YES - too much MDMA can certainly decrease the experience of LSD and mushrooms.
And life.

I will also mention that some of the WORST cases of DP, anxiety, and destruction of life that I have encountered among MDMA users included the use of LSD. While the combination may be incredible and life-changing, I would consider it much more dangerous to the Prefrontal 2a receptors than either on their own.

Make it a once in a lifetime event, not one to be repeated.
It is repeated psychedelic drug users that are the MOST damaged by MDMA, in my opinion.
And limit your use of MDMA to 200mg or LESS per night, spaced by at least 90 days in between rolls.
No re-dosing.

MDMA is definitely neurotoxic, so combining it with any drug that has powerful agonist effects on 5HT receptors is pretty risky.
Although LSD is thought to be non-neurotoxic, this reflects a limited understanding of how LSD affects the brain.
LSD is rather difficult to study, so a lack of neuronal death does not equate 'safety'.

Long-term LSD users often exhibit major changes in personality, and permanent life-long alterations in color-perception and visual processing.
Some will develop severe psychosis similar to that seen in MDMA users and schizophrenia.
Try telling them that 5HT-2a agonism has no 'toxicity'.

With all drugs, dosage is CRITICAL.
No drug is safe, in high enough or repeated doses.
LSD should be taken moderately, like everything else.

It has 100 times the affinity for the 2a receptor than mushrooms!
 
Not sure about mushrooms but there is a bit of a tolerance between MDMA and LSD. If you take one on Friday night, another on Saturday night, the Saturday night will be different, probably it will be "less" of a roll/trip. It's not dangerous like doing MDMA two nights in a row.
I'm not sure how long it takes to break that tolerance, but I wouldn't do MDMA and LSD on the same weekend unless it was like an amazing festival or something. Save them for different weekends if you can.
 
Taking MDMA when you're tripping hard on Acid will intensify everything. I went from watching colourful gemoetry to watching colour literally burst from corners in my room like Party Poppers. It makes everything very cartoony, mental.
 
StrutterGear said:
Taking MDMA when you're tripping hard on Acid will intensify everything. I went from watching colourful gemoetry to watching colour literally burst from corners in my room like Party Poppers. It makes everything very cartoony, mental.
Click to expand...

Yeah mate i've experienced this before, very fun indeed. But i took the acid when i got back to my friends house after being up all night on MDMA and i found that the ecstasy just 'sugarcoated' the acid trip if you get me? I felt that both of the buzzes actually really complimented each other in so many ways. Serriously cannot wait to candyflip again, but next time i'm going to do the the acid first, then wait about 2 hours and then do a nice bomb of mandy :) . I've heard that this is the best way to do it from numerous people, as you get the clarity first and then follow it up by adding the ecstasy buzz to it

nice one fella :)
 
candy flipping(LSD and MDMA) is lots of fun and has quite a synergistic effect. i do believe there is some cross tolerance although i've never rolled and then tripped on consecutive days to experience it myself.
 
dnbraver2010 said:
Yeah mate i've experienced this before, very fun indeed. But i took the acid when i got back to my friends house after being up all night on MDMA and i found that the ecstasy just 'sugarcoated' the acid trip if you get me? I felt that both of the buzzes actually really complimented each other in so many ways. Serriously cannot wait to candyflip again, but next time i'm going to do the the acid first, then wait about 2 hours and then do a nice bomb of mandy :) . I've heard that this is the best way to do it from numerous people, as you get the clarity first and then follow it up by adding the ecstasy buzz to it

nice one fella :)
Click to expand...

Yea it's important to know the differences in the trip. I didnt bomb any MD until ~4 hours into the trip and I was tripping HARD. I like the acid buzz though, it feels so clean. I always say an acid trip is like a ket+mdma trip, except add psychedila patterns and no body load. Feels so weird having no body load, must be just cause I'm use to other drugs :P Candyflipping and dancing is just too good, it should be illegal .......

g37423_Ba%20dum%20tiss.jpg
 
mushrooms go nicely with mdma very mental and visual ime, have had some very intense trips on mushrooms+mdma, i always recommend eating the lsd or mushrooms 1st and getting settled into the trip then consume the mdma aswel. always start off low doses untill you actually know how your body reacts to the combo aswel always better to be safe than sorry
take it easy everyone!
 
First Bad Comedown said:
And MDMA, as a potent releaser and agonist...
Actually causes a LOSS of 5-HT2a receptors, especially in the precious Prefrontal Cortex (highest cognitive center).

Former MDMA users that have undergone imaging have displayed loss of serotonin and 2a receptor density in the frontal lobes.
Even long into abstinence...2 years or more.
And it is presumed that although recovery may continue, original density will be forever lost in these people.
Click to expand...

Can you link me to the study that claimed this mate? Because obviously the amount of serotonin in your brain will vary from day to day regardless of whether you've ever taken ecstasy.

And incidentally the latest anti-depressants are based on DECREASING the amount of serotonin in your brain so the alleged "loss of serotonin" may not be a bad thing.

I'd also be interested in how long they carried out this "study" that you're quoting. They kept checking people for 2 years or more and they showed damage? How come the latest and biggest study into E ever done recently concluded that:

There is no evidence that ecstasy causes brain damage, according to one of the largest studies into the effects of the drug. Too many previous studies made over-arching conclusions from insufficient data, say the scientists responsible for the research, and the drug's dangers have been greatly exaggerated.

"I always assumed that, when properly designed studies were carried out, we would find ecstasy does not cause brain damage," said Professor David Nutt

http://www.guardian.co.uk/society/2011/feb/19/ecstasy-harm-brain-new-study

I will also mention that some of the WORST cases of DP, anxiety, and destruction of life that I have encountered among MDMA users included the use of LSD.

Can you link me to the study showing this? Or is this just a feeling you've got in your water?

MDMA is definitely neurotoxic

That's not really telling the whole story tho. If you inject enormous amounts of E directly into a rats brain every 3 hours for 4 days in a row, then cut the rats brain open, you may see damage to some cells and nerve endings. The question is how that relates to a human being taking a pill orally. And how this all relates to actual brain damage in the sense of anyone noticing anything. Obviously every time we walk down a busy street we are breathing in car pollutants than can cause brain damage in the lab - but we all seem to function perfectly well all the same.

Long-term LSD users often exhibit major changes in personality, and permanent life-long alterations in color-perception and visual processing.
Some will develop severe psychosis similar to that seen in MDMA users and schizophrenia.
Try telling them that 5HT-2a agonism has no 'toxicity'.

Complete horseshit.

No drug is safe, in high enough or repeated doses.

Nothing is safe in high enough doses - if you drink water in a high enough dose every cell in your brain will burst. Does that make water unsafe?
 
austins312 said:
Think about it, ecstasy releases serotonin, and magic mushrooms and LSD bind to serotonin right so could taking MDMA decrease the effects of magic mushrooms and LSD?
Click to expand...

No, taking LSD and mushrooms on the same day will enhance the effects of both. It's a beautiful trip.

You may notice some decrease in the effect of LSD if you take it a day or two after a heavy MDMA session tho.
 
FBC said:
And MDMA, as a potent releaser and agonist...
Actually causes a LOSS of 5-HT2a receptors, especially in the precious Prefrontal Cortex (highest cognitive center).

Former MDMA users that have undergone imaging have displayed loss of serotonin and 2a receptor density in the frontal lobes.
Even long into abstinence...2 years or more.
And it is presumed that although recovery may continue, original density will be forever lost in these people.
Click to expand...

Are you positive it actually gets rid of the receptors? I read it just makes them less effective. And that depressed individuals were found to have more than normal people.

Based on what you said, and the studies I read, previously depressed MDMA abusers would actually gain benefit over their depression from abuse.

That doesn't sound right at all.
 
Just used up my time on another post, so I will check on my resources tomorrow.
But I'm pretty sure that it is the 2b receptor that is increased in MDMA users.
This is a compensatory mechanism, likely to maintain blood flow and function.
Over time, some of these go away.

But the 2a receptors are much more valuable and are seen to be reduced in PFC of former users.
At least in imaging studies, this is observed.
But I will try to post references tomorrow.
And when I have time, I will get back on the "legalization' thread...gotta keep it going.

Until then.
 
Really people?

hes not talking about doing LSD and mushies on the same day, what hes asking is:

Does heavy use of MDMA decrease the intensity of later trips? And I would say yes, atleast while you serotonin is at very low levels, over use of MDMA will decrease the effects of MOST drugs that release sert., because theres simply just less there to release
 
Folley said:
Really people?

hes not talking about doing LSD and mushies on the same day, what hes asking is:

Does heavy use of MDMA decrease the intensity of later trips? And I would say yes, atleast while you serotonin is at very low levels, over use of MDMA will decrease the effects of MOST drugs that release sert., because theres simply just less there to release
Click to expand...

LSD and mushrooms don't "release serotonin".
 
First Bad Comedown said:
Mushrooms and LSD are both 5-HT2a agonists.
Of all serotonin receptors, which there are many, the 2a is most associated with the euphoria and hallucinations of psychedelic drugs.

And MDMA, as a potent releaser and agonist...
Actually causes a LOSS of 5-HT2a receptors, especially in the precious Prefrontal Cortex (highest cognitive center).

Former MDMA users that have undergone imaging have displayed loss of serotonin and 2a receptor density in the frontal lobes.
Even long into abstinence...2 years or more.
And it is presumed that although recovery may continue, original density will be forever lost in these people.

Current users almost ALWAYS show a loss of function, which could be caused by the transient effects of the drug.
But a portion of abstinent users go on to retain this loss for many years, suggesting definitive neurotoxic effects.
So YES - too much MDMA can certainly decrease the experience of LSD and mushrooms.
And life.

I will also mention that some of the WORST cases of DP, anxiety, and destruction of life that I have encountered among MDMA users included the use of LSD. While the combination may be incredible and life-changing, I would consider it much more dangerous to the Prefrontal 2a receptors than either on their own.

Make it a once in a lifetime event, not one to be repeated.
It is repeated psychedelic drug users that are the MOST damaged by MDMA, in my opinion.
And limit your use of MDMA to 200mg or LESS per night, spaced by at least 90 days in between rolls.
No re-dosing.

MDMA is definitely neurotoxic, so combining it with any drug that has powerful agonist effects on 5HT receptors is pretty risky.
Although LSD is thought to be non-neurotoxic, this reflects a limited understanding of how LSD affects the brain.
LSD is rather difficult to study, so a lack of neuronal death does not equate 'safety'.

Long-term LSD users often exhibit major changes in personality, and permanent life-long alterations in color-perception and visual processing.
Some will develop severe psychosis similar to that seen in MDMA users and schizophrenia.
Try telling them that 5HT-2a agonism has no 'toxicity'.

With all drugs, dosage is CRITICAL.
No drug is safe, in high enough or repeated doses.
LSD should be taken moderately, like everything else.

It has 100 times the affinity for the 2a receptor than mushrooms!
Click to expand...

Is this based on people who have abused MDMA and use it to frequently. For someone who does MDMA no more than every 6 months theoretically approximately how long would it take to Recover the 5-HT2A receptors to ensure it does not interfere with Tolerance to Mushrooms or something similar?
 
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