Can dmt lead to an alergic reaction? Plz help

[Flinch]

G'day

I tried dmt for the 1st time on friday night, all up would of smoked 120mg or so. Didnt feel any negative side effects after. On sunday night, i started to notice mosquito like bumps on my arms, then, I jst thought a mozzi was loose in my room or something. Then more started to pop up, then it spread and was all up n down my arms, over my upper chest and pretty much 80% of my back was red and bumpy etc.

I went to doctor and she said it was a severe allergic rxn, and asked if i had done anything new, im like, i tried dmt for the 1st time on Friday (She said "Is that ice?" rofl) I told her its a hallucinogen that i smoked. She said its possible it could be it, and nxt time the rxn might be more severe (swelling of throat etc)

Now, I really doubt that this could be it, due to taking it friday, i smoked it, i havent had any reaction to lsd or shrooms, and it occurs naturally in the body (Altho this might not mean nethin due to low concentration).

There are only 3 things else i can think of. I had Moroccan lamb from a supermarket i hadnt had before (had that Sunday nite) and my sisters bf gave me some lil sample bottles of colone, and 2 of them were in unmarked bottles n smelt cheap (other 2 were Armani n gio, n smell great) So could putting a lil bit of that on my wrist cause it? Or maybe ive developed a allergy to peanut butter, even tho i always eat the stuff.

Im really quite worried because its scary that i dont know what it is and it could possibly kill me next time =\ Anyone have any ideas?

 

[getDODI]

DMT is naturally occuring in your brain. Do you dream at night? I bet on the DMT itself is not possible to be allergic to. But there always is a freak! lol


DMT is not for the faint of heart. Its a over-whelming at times. Breathing does get hard, my buddy has asthma so he like slowly breaths every time to calm himself down. Not drinking enough water causes things like this. Not eating healthy, not properly taking of your body causes swelling of the throat.

Try eating healthy next time before blasting off.

 

[MurphyClox]

If the allergic reaction was due to the DMT it should have developed much faster. So, when you smoked the DMT friday night you're supposed to experience such reactions directly afterwards. Minutes, maybe one hour; most probably not later.

One cannot exclude the possibilty at all that somebody is allergic to DMT but 1. it's highly unlikely 2. it came too late (as said above). Considering the very fast metabolic degradation it is even more unlikely... BUT it is possibly, of course.!!!

DMT is not for the faint of heart. Its a over-whelming at times. Breathing does get hard, my buddy has asthma so he like slowly breaths every time to calm himself down. Not drinking enough water causes things like this. Not eating healthy, not properly taking of your body causes swelling of the throat.

Try eating healthy next time before blasting off.

WHAT? If it really was an allergic reaction - and it sounds very much like one, then "eating something healthy before" doesn't help a fuck. And "faint of heart"???? What is that supposed to be? Again: Allergies don't care about your will and "strength/faint of heart". This is completely dumb!

So, your guess about the new perfume sounds FAR more probable to me. Even the expensive ones (Armani...) can cause something like this.

Peace! Murphy

 

[Flinch]

DMT is naturally occuring in your brain. Do you dream at night? I bet on the DMT itself is not possible to be allergic to. But there always is a freak! lol


DMT is not for the faint of heart. Its a over-whelming at times. Breathing does get hard, my buddy has asthma so he like slowly breaths every time to calm himself down. Not drinking enough water causes things like this. Not eating healthy, not properly taking of your body causes swelling of the throat.

Try eating healthy next time before blasting off.

I handled the dmt just fine, was abit scared at a point or two, but i was fine.

Thanks MurphyClox for the reassuring words. Im going to be exploring this amazing chemical in a more relaxed setting where time is of no worry tomorrow, It'll be good not having to worry about having an allergic reaction.

 

[MurphyClox]

Oh then plz post if anything unusual occured. Thx! Good luck with your trip!

 

[Black]

dmt should be too small for the immune system to recognize. besides you have small amounts dmt in your blood all the time. the perfumes are much more likey to have caused your reaction.

 

[dankoni]

My vote goes to the cologne as well. Both the lamb and the cologne are more likely to have caused this reaction.

 

[negrogesic]

As mentioned it is relatively unlikely that you would develop a localized allergic reaction 2 days after consumption of the DMT. Was it the orange sludge, or was it crystalline (an adverse reaction is more probable in respect to the former, however this would still be very uncommon)..

 

[Ham-milton]

What he describes doesn't sound like anything from DMT. If anything, I'd expect swelling in the throat before anything on the skin.

There's no real proof that DMT causes dreaming, unfortunately.

Were you anxious afterwards? I've had friends who developed similar symptoms after a semi-bad trip- itchy bumps on their arms and chests. Just anxiety, though.

 

[Tranced]

Zophen thought he had one if I remember rightly, but it was with Ayahuasca and he thought it was something in with the plant material.

 

[getDODI]

dmt is released when you die. In theory you have a 5-10 dream when you die.

that dream is related to your same dream at night. its like undeniable the relativity. if its not proven its almost undeniable.

-*note pure white crystal form won't make your allergic. Don't quote me but I really dont see it possible. Any other form, anything I feel anything is possible.

The reason i stated eat healthy is because digesting ayahausca is usually done after a week of body cleansing. They are partly the same molecule, equally your high should be better if your in better shape.

 

[Ham-milton]

dmt is released when you die. In theory you have a 5-10 dream when you die.

that dream is related to your same dream at night. its like undeniable the relativity. if its not proven its almost undeniable.

This is all speculation, it was originally proposed by Callaway in 1988 but there is absolutely no evidence that it actually occurs.

The italicized sentence makes no sense, if you could explain what you meant, I could perhaps respond to it.

Underlined sentence: If you cannot deny something with zero supporting evidence, you're not applying the rigorous critical thinking neccessary for good science. Accepting this is nothing more than wishful thinking.

To date there's also no confirmation that it's produced in the pineal gland as is often claimed either. There are methyltransferase enzymes, and it does produce the related melatonin, but so far there's no confirmation.

There's also no confirmation that it's released upon death. That's just another Strassman supposition without backing.

Lots of speculation, not much real research.

 

[indelibleface]

On a related note...

The first and only time I took 2C-I, I had an allergic reaction in the morning to the cold air outside my apartment. My hands, feet, and knees suffered a very itchy urticaria reaction that was relieved with the use of an antihistamine. For several years afterwards, I had similar reactions to cold weather. This never happened before my 2C-I experience. Only in the past year have I not experienced any reactions.

It seems that the 2C-I might have somehow sensitized me to cold weather, however ridiculous that might sound. It could easily be sheer coincidence, but it is odd that I would have taken an unfamiliar chemical one night, and the next day, for the next couple years, suffer allergic reactions when exposed to cold weather for long periods of time. Odd!

 

[getDODI]

This is all speculation. ..........

There's also no confirmation that it's released upon death. That's just another Strassman supposition without backing.

Lots of speculation, not much real research.

Ill have to get back to you on this, I hate sounding completely retarded with half truths. But basically I always read that DMT is released when you dream and die were true. Thats like the only explanation of why we dream. Melatonin we recreate synthetically its not the same thing. But DMT in our and brains and in the plant is ? Correct me if/where I am wrong I am not anywhere able to say I am a professional on this topic in any manor.

But how do you we explain somebody dieing[ no heart beats], and the dead person reporting what they see when they somehow came back to life?

This idea was brought to my attention out of a quantam physics movie thats made like scanner of darkly. When two people in bed talking about, i think it
s terrance mckenna idea{sp?}, how he can't wait until he dies because this is released?

I was never informed this was never true, only speculation? I was always led to believe this was true. Anywho thats why we have conversations

 

[Ham-milton]

Ill have to get back to you on this, I hate sounding completely retarded with half truths. But basically I always read that DMT is released when you dream and die were true. Thats like the only explanation of why we dream. Melatonin we recreate synthetically its not the same thing. But DMT in our and brains and in the plant is ? Correct me if/where I am wrong I am not anywhere able to say I am a professional on this topic in any manor.

Yeah, it's commonly passed on as if it were truth, but unfortunately we don't have any verification of these things yet. Melatonin is also produced endogenously in the pineal gland. It would make sense that a gland that produces one methylated tryptamine, has the neccessary methyltransferases could also produce N,N-DMT, but it just hasn't been confirmed yet.

But how do you we explain somebody dieing[ no heart beats], and the dead person reporting what they see when they somehow came back to life?

This idea was brought to my attention out of a quantam physics movie thats made like scanner of darkly. When two people in bed talking about, i think it
s terrance mckenna idea{sp?}, how he can't wait until he dies because this is released?

There are certain to be lots of brain processes happening during death- probably massive disruptions of normal proccesses. DMT doesn't make much sense because the sorts of visuals you experience during dreams and (what's been reported to me) are not at all similar to typical DMT-esque visuals. They don't appear serotonergic at all.

I was never informed this was never true, only speculation? I was always led to believe this was true. Anywho thats why we have conversations

Yep, it's not really something most people search out information on, and it's really just been passed on as an urban legend. It may or may not be true. It's hard to say. There are strong reasons behind the thought, but there were strong reasons to think the world was flat.

neccessary words to let me submit my reply as formatted

 

[raybeez]

The above described reaction is consistent with a delayed type-1 hypersensitivity (allergic) reaction and should be taken very seriously . This would be an example of a sensitization (or 'priming') reaction, which occurs the first time the body encounters an allergen. Antigen presenting immune cells 'capture' the allergen, bring it back to the lymph nodes, and present it to your bodies B-cells. These B-cells 'learn' to be specific for the given antigen, replicate, and produce an antibody called IgE.

This entire process takes 24-48 hours, and the result is a spike in circulating IgE in the blood, inducing late-phase dermatological eruptions/rashes. Subsequent exposures to the same allergen will induce classical anaphylaxis with a risk of death. This occurs because the B-cells previously activated retain a memory of the allergen, and respond with a very intense and localized burst of IgE at the site of exposure (e.g. throat/lungs). IgE binds to mast cells, causes a huge histamine release, and anaphylaxis results.

First exposure to an allergen almost never causes anaphylaxis, and almost always presents with a rash 24-48hrs later as you've described. You'll only see anaphylaxis on a first exposure in certain situations, such as IV administration of the allergen, or after a massive exposure via other routes.

-----

So what in the DMT could be responsible for this reaction? As negrogesic was hinting at above, plant source DMT could easily be contaminated with plant proteins which could provoke this type of response.

Black on the other hand is completely wrong in suggesting that DMT is too small to be recognized by antibodies. It's true that organic molecules are almost never recognized by antibodies. However, alkaloids (which DMT is) can in fact sensitize individuals and provoke very strong and potentially deadly immune reactions. A good example of this are opiates, with IgE responses to morphine being very common.

Best advice: DON'T SMOKE DMT AGAIN!

 

[Black]

Black on the other hand is completely wrong in suggesting that DMT is too small to be recognized by antibodies. It's true that organic molecules are almost never recognized by antibodies. However, alkaloids (which DMT is) can in fact sensitize individuals and provoke very strong and potentially deadly immune reactions. A good example of this are opiates, with IgE responses to morphine being very common.

thanks for that info. you never cease to learn…
i thought the molecules would at least have to have the size of lsd or morphine.

woudn't do the levels of dmt occurring naturally in the blood elicit an immune response if one was allergic to it, or are the concentrations too small? i have found no definitive numbers as to how high they are. abstracts from research from the 70s seem to suggest them to be around 1ng/ml.

 

[MurphyClox]

@raybeez: Thx man, finally somebody who knows it best. I have to admit that even some of my statements were not correct, especially about the time-related part (24-48 h later!). My honest apologies in this place!
Just to make it clear: The first response (the one that Flinch described) occurs like 1 or 2 days afterwards of the immunogen application, this I understood. But at repeated exposure the immune response should occur much faster, right? Like the 1-2 hours that I suggested first. I didn't like immunology a lot during my studies, here comes the payback

Again I have to emphasize that "healthy food" doesn't change anything related to this topic. As raybeez clearly pointed out this whole incident has something to do with an immune system reaction. Period. No food in the world will prevent this to happen again.
And to clear out just another myth: Fasting is in no way some kind of "body cleansing" even if it's stated again and again in (pseudo-)health publications or whereever. If it makes you feel better - OK. I won't disagree. But it doesn't clean anything at all from your body. On the other hand, loosing weight does. But this is something different. Some of the indian tribes in regions where ayahuasca is common even forbid sex some days before a trip. You see, these are more some kind of moral implications then rational ones.

Peace! Murphy

Best advice: DON'T SMOKE DMT AGAIN!

Yes Yes Yes!

 

[raybeez]

woudn't do the levels of dmt occurring naturally in the blood elicit an immune response if one was allergic to it, or are the concentrations too small? i have found no definitive numbers as to how high they are. abstracts from research from the 70s seem to suggest them to be around 1ng/ml.

I'd like to read some of the original papers that describe DMT as an endogenous tryptamine. I'm highly skeptical that DMT would be present at detectable levels in blood/serum. My reasoning for this is that DMT is rapidly degraded by the enzyme monoamine oxidase, which is present in the blood (within platelets) as well as the liver. This is the reason why oral DMT is inactive unless combined with an MAOI.

If it is the case that the 70s research was describing the presence of DMT in brain tissue or cerebral spinal fluid (CSF), this wouldn't be inconsistent with having IgE antibodies against DMT. Like so many other things, antibodies are too large to cross the BBB, and react with brain tissue DMT.

Just to make it clear: The first response (the one that Flinch described) occurs like 1 or 2 days afterwards of the immunogen application, this I understood. But at repeated exposure the immune response should occur much faster, right? Like the 1-2 hours that I suggested first.

Yes, you are correct here. It is only the initial, first time sensitization reaction that happens in a delayed manner. Now that the immune system has been primed, it will respond faster, and more severely (anaphylaxis). This would only take 1-2 hours at most (if eaten), and could happen even faster if smoked/injected/snorted/etc.

 

[Ham-milton]

Being that DMT is destroyed so rapidly, it'd likely be entirely gone by a day, probably by 12 hours. How does a delayed reaction occur to something that'd be entirely gone by that point?