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Can anyone think of a possible pro-drug for MDXX?

MagickalKat777

MagickalKat777

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I think this would be the most promising area of research... making a prodrug that is converted in vitro into an MDXX. It has to be possible to do although I'm sure the synth would be difficult. Any ideas? I'm not a chemistry major as people know but I do have great ideas for potential chemicals... if we could find a chem that had a side chain that was broken off leaving the desired compound, I think we would have a whole new class of drugs just like what happened with the 4-Acetoxy tryptamines.

I'm over the 5-Methyl-MDA and 4-Desoxy-MDA (6-APBD) crap... I don't think its going to be worth it after researching...
 
With Vyvanse (lys-dexamphetamine) the lysine molecule is cleaved in vitro. I'm sure because of their structural similarity some kind of amino-acid-bonded MDxx would work similarly.
 
Wouldn't this make more sense than making some dodgy chemical that nobody knows anything about the toxicity of nor the effects until they've synthed it? I would rather have it turn into MDXX in vitro than take something that is supposed to partially mimic but fails completely (besides methylone in a decent dose but still redosing methylone is a bitch of a stimulating fucknut comedown) - and since they are already going the amphetamine route, might as well find a prodrug that will get cleaved in vitro to the active compound...

Picamilon works this way... nicotinyl bond gets cleaved and leaves GABA...
 
The problem is you are probably gonna need MDMA to make it, and quite possible have detectable amounts left in it, so legally it's a little scary. Still love to try some though.
 
MagickalKat777 said:
Wouldn't this make more sense than making some dodgy chemical that nobody knows anything about the toxicity of nor the effects until they've synthed it?
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Pro-drugs need to be broken down inside the body to convert it into the desired drug.. this sometime's leave toxic metabolites which could be more dangerous than a completely new chemical.
 
magicalkat, in vivo. "Vitro" is like vidrio in Spanish: glass
 
I'm waiting on trying the 2-methyl-butan-2-ol carbamate derivative of MDA still.

Not to discuss synthesis, but it is possible to go from aldoxime-to a one carbon larger amide, which can undergo hoffman degredation which gives an isocyanate.

Under completely fucking well anhydrous conditions, an isocyanate forms a carbamate with an alcohol. Thus avoiding posession of actual MDXX.

Stomach acid should cleave this carbamate into 2M2B and MDA, giving two goodies for the price of one, and smoothing out the MDA some at the same time.
 
Considering how cheap MDMA is in the illicit market and the facts that the dose of pure MDMA is high and some of these prodrugs the dose would be astronomical, Even if they could find an affordable legal way to make it and make it without any illicit contaminants, I doubt it would be very profitable for any vendor to make a Fenethylline, benzphetamine or lysamphetamine analog which acts as an MDX prodrug since due to the substantial increases in molecular weight, the doses would have to be so huge the price would have to be even cheaper than mephedrone was at it's cheapest to be a viable alternative to MDMA. There's also the issue of many prodrugs forming illegal drugs upon environmental exposure like FLEA
 
Atara-because I am very sensitive to stimulants, and overstimulation is often the case for me.

Besides, the lab work will be fun:p
 
@Limpet:
Sorry for nitpicking pal, but as we already discussed elsewhere, it won't be possible for you to avoid traces of the MDXX-compound in your prodrug preparation, which GC/MS won't be able to detect with ease. Seriously, no matter which endeavours you undertake. I really don't mean to stop you but rather like to point out that you will not be able to do this all legally, as was your intention. The idea is very interesting though and I really can't wait to read see some results.
As a reminder, do not forget that GC/MS-sensitivity goes down nM-levels and below already with standard procedures.


With regard to the suggested amide-prodrugs a lá lisdexamphetamine, I don't think that they will be worthwhile. Metabolic cleavage to the active drug happens to slow. I think that was actually the main reason why lisdexamp was brought to the market: Slow release, no rush, lesser abuse liability.


- Murphy
 
MagickalKat777 said:
Well 4-AcO-DMT has psilocin in it as a breakdown product...
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That is correct of course, but...

Psilocin isn't required to make 4-aco-dmt.

You have to consider law in the country of origin as well as here. Not an expert on chinese law but apparently psilocin isn't illegal as a couple places there offered it at one time, MDMA probably is.

Joe six-pack hasn't heard of psilocin, MDMA he has.
 
All very interesting points... It was more tossing a possible harm reduction idea around than anything. Wish it could go somewhere but its probably not worth the effort. It is unfortunate because it means that potentially extremely toxic compounds like 6-APB will flood the market...

And in vivo lol. I was a bit muxxed last night. :)

EDIT: What if we found something that would break down as soon as it hit the stomach rather than going through metabolic pathways? Or would that likely release a toxic gas into our GI? lol. Find something that will be completely destroyed by the stomach and find a clever way to attach it to the MDXX drug of choice... it hits the stomach and within seconds is actually MDXX... I'm sure its possible to do but I bet the synth would be expensive.

And on the Chinese labs - I know Chinese labs that manufacture LSD without thinking twice... Chinese law generally prohibits them from distributing it in THEIR country, not making it and sending it to other countries,
 
fryingsquirrel said:
That is correct of course, but...

Psilocin isn't required to make 4-aco-dmt.

You have to consider law in the country of origin as well as here. Not an expert on chinese law but apparently psilocin isn't illegal as a couple places there offered it at one time, MDMA probably is.

Joe six-pack hasn't heard of psilocin, MDMA he has.
Click to expand...

BTW psilocin IS controlled under Chinese law... I really think they just turn the blind eye when it comes to EXPORTING illegal drugs... most MDMA precursors come out of China anyway...
 
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