NeuroPsyence
Bluelighter
- Joined
- Apr 30, 2011
- Messages
- 76
I think this concept will be easiest for me to understand through an example, so here's a hypothetical situation.
Substance D has an elimination half-life of 3 hours. It produces one metabolite, which has identical pharmacological activity, but an elimination half-life of 8 hours.
Can an effective half-life be calculated for the combined effects of the parent substance and its metabolite? Is it simply additive, or is the calculation more complex than that?
Thanks in advance for the information/explanation!
Substance D has an elimination half-life of 3 hours. It produces one metabolite, which has identical pharmacological activity, but an elimination half-life of 8 hours.
Can an effective half-life be calculated for the combined effects of the parent substance and its metabolite? Is it simply additive, or is the calculation more complex than that?
Thanks in advance for the information/explanation!