The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
I read that caffeine blocks GABAa receptors, and here's some of what I read...
with several mechanisms of action, such as non-selective antagonism of adenosine receptors, as the high-affinity A1 and A2A adenosine receptor (A1R and A2AR) subtypes, inhibition of cyclic nucleotide phosphodiesterases, mobilization of Ca2+ from the sarcoplasmic reticulum or inhibition of its reuptake, inhibition of monoamine oxidase and cyclooxygenase enzymes, and blockade of GABAA receptor.
Then I read that caffeine potentiates the release of GABA. So I'm confused, and would it effect my benzos at all? For the last couple years I've been trying to stay away from Caffeine, because of it's Adenosine antagonist effects, but haven't read that Caffeine blocks GABAa receptors that I can remember atleast.
What do you guys think about this? Does anyone know what caffeine really does to GABAa receptors?
with several mechanisms of action, such as non-selective antagonism of adenosine receptors, as the high-affinity A1 and A2A adenosine receptor (A1R and A2AR) subtypes, inhibition of cyclic nucleotide phosphodiesterases, mobilization of Ca2+ from the sarcoplasmic reticulum or inhibition of its reuptake, inhibition of monoamine oxidase and cyclooxygenase enzymes, and blockade of GABAA receptor.
Then I read that caffeine potentiates the release of GABA. So I'm confused, and would it effect my benzos at all? For the last couple years I've been trying to stay away from Caffeine, because of it's Adenosine antagonist effects, but haven't read that Caffeine blocks GABAa receptors that I can remember atleast.
What do you guys think about this? Does anyone know what caffeine really does to GABAa receptors?