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By what mechanism does cannabis cause paranoia?

Well there is certainly a heavy change in the meslimbic area, I would not be surprised if your body released norephinephrine like crazy as a result of smoking and being startled.

As for the real culprit of norephinephrine being released and bound like crazy, I would remind you that cannabis is a psychedelic drug, although very low on the totem poll. Panic can sometimes come with that class of drugs, and some people are more prone to it. I'm not sure there is a real neuroscientifc answer to this, and if there is, I'd be interested in seeing what neurochem is actually going on.
 
Everyone blaming the legal status is chattin shit (no offence).. To be honest i've never cared too much about being caught + there are times when im in my house and KNOW i wont get caught..

Then there's the fact that my paranoia never has anything to do with police / getting caught.

It's a pharmacological mechanism of some kind.. wether known or not.
 
I think it's mostly because your state of mind changes, so does your reaction to it. Kind of like when your REALLY tired and you get really emotional, I don't think lack of sleep changes anything specific but because your body slows down you start acting different as a side effect.

So when you smoke weed you are feeling a high, thus you act differently towards the same situations.
 
But I don't flip into the panic switch when I start flying up on a 4-sub tryptamine (except mushrooms) and 4-HO-MET in particular you go from sober to peak in less than 10 minutes... I think there must be adrenergic activity involved that causes the panic reaction.
 
SomeDudeHere said:
I think it's mostly because your state of mind changes, so does your reaction to it. Kind of like when your REALLY tired and you get really emotional, I don't think lack of sleep changes anything specific but because your body slows down you start acting different as a side effect.

So when you smoke weed you are feeling a high, thus you act differently towards the same situations.
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Well.. yeah.. ok? But some drugs are alot more likely to cause certain things over others.. Which brings us back to the question: What causes paranoia with cannabis? ;)
 
a change in blood pressure and increased heat beat? I know many people panic because their heart is racing and they get scared because of it. Though there are probably many reasons for it.
 
^ The physiological changes will attribute to anxiety.. ala panic attack.. but paranoia is something else.. I guess paranoia could start with anxiety or visa versa..
 
doIhavePotential said:
a change in blood pressure and increased heat beat? I know many people panic because their heart is racing and they get scared because of it. Though there are probably many reasons for it.
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Actually I find in most cases that people THINK their heart is racing when its actually not, its the body high of the drug causing intense, fast, rushing sensations.
 
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