Burenorphine dose for stroengest effct & soonest time to redose for strongest effect?

[Anon54]

Burenorphine dose for stroengest effct & soonest time to redose for strongest effect?

You get MUCH higher when you get your bupe dose below 2mg per use.

I was once on 16mg a day back in my teens, and barely felt each dose because my receptors were always so saturated so I didn't get any euphoria - which is associated with the increasing levels on bupe after each dose.

I went down to 1mg three times a day and felt it much better.

Then I quit for 3 days, went into withdrawals, then took .5mg and was completely high like I had taken a strong dose of hydrocodone.

The lower the dose, the quicker your body eliminates the bupe after each dose, therefore the bigger increase you'll feel after each dose, hence increased euphoria.

You can drop from 32mg to 8mg in a week. Tolerance adjusts extremely fast with bupe both up and down.

So im trying to use them recreationally cuz i only have a few. what dose would u recommend if the smaller the dose the better. I'm sure .000001mg would be weaker than 1mg, right? Maybe the strongest dose would be 0.25mg. I don't know. That's what I'm trying to find out.
It's gunna be hard to cut an 8mg in to 32 pieces. I could just bight off tiny little chunks.

Anyways... It doesn't make sense & I'm having trouble believing it. I can understand 4mg giving u the same high as 1mg. but i don't understand how 4mg would give u less a high. I'm wondering why they have 8mg tablets when they are weaker than the 1mg tablets.

So could someone please explain to me the most recreational dose & why?

Next..
When to re-dose. This one could be hard to know because re-dosing to quick would increase the previous dose in ya system making it weaker. You could probably work out the optimal time to re-dose by its half life. Shit I just looked it up. it has a half life of 20-70 hrs. i know that's the time for half the drug to leave ya system but it confuses me now when the best time to re-dose would be. its half life, 45hrs or 2 days later when it's left ya system? (That just doesn't sound right)

anyways I'm going to try to google some info on the strongest doses (The celing dose is 32mg but according to Citiokid it certainly isn't the strongest. Ive never heard of a drug where at a point if u raise the dose it gets weaker. It doesn't make sense to me. i don't need to know how it works I suppose as long as i know how to get the most out of the small amount of subs Ive got left, I'll be happy

To think I took 24mg last night & could have got higher with 1mg & for 24 days.

PS. The mods have been closing most of my threads lately & I have been UTFSE, Im sure there's a lot of ppl who want to know the perfect dose for bupe. they may be taking to much & wasting it. or taking it to often & wasting it. So if u think the info is already available maybe u should try to answer it yaself as u close this thread down.

 

[effie]

Wait - I think there is some confusion here. When most people say "bupe" they mean buprenorphine. Do you mean bupropion?

I'm going to assume buprenorphine:

No, it does not get weaker if you take higher doses.

Higher doses are stronger. However - buprenorphine is only a partial opioid agonist, instead of the full agonists like most other opioids. This means it does not have quite the same high as the rest and it can feel somewhat lacking recreationally. Some people don't get much off it at all, where as others get really high, but nearly everyone finds it different to full opioids.

However, is has an active metabolite, norbuprenorphine, which is a fiull agonist. At low doses (2mg or less) norbuprenorphine plays a significant role in it's effects, therefore buprenorphine feels much more like a full agonist. At higher doses norbuprenorphine only has a limited role. Therefore, a <2mg dose can feel more like a "proper" opiate. It is not stronger, but it has the full agonist action that buprenorphine on it's own is missing.

1mg bupe = roughlly 40mg oxycodone, but it won't feel like 40mg oxycodone necessarily. Buprenorphine is still a strong opioid though and you need to be careful with it and not take huge doses as this can be dangerous.

It may just be that you don't get much from it recreationally..

In terms of redosing - what do you want from it? Buprenorphine takes a while to reach full effects, and lasts all day (opioid addicts on it for maintenancy only need to dose every 24 hours because it lasts that long). You can't really accurately titrate your dose by taking some, then more if it's not working, because of this slow build up. You can take more but you should leave it a few hours in between.

Sorry for closing your threads - to make sure they stay open remember to think about the guidelines, whether this is the right forum, and whether you've had a similar thread recently which you could add to instead. Hope that's okay!

 

[Anon54]

Effie read my post again. Ive edited it a bit.
So u disagree with CitioKid?

He says 1mg 3 times a day was stronger than 16mg once a day.
3mg a day is stronger than 16mg a day. Is this correct or not?

Is there a dose of bupe (yes buprenorphine) that if u exceed it starts to decrease its effect or even just stops getting stronger. Obviously it stops at 32mg because that's it's ceiling dose, but is there a dose lower to that where any of those 2 things happen?

the post by CitioKid has got me really confused. that's all...

I'd assume that as u increase the dose of buprenorphine the effects increase but start to increase slower & slower until u reach 32mg where it doesn't increase anymore. that's what I would assume. Does THAT sound right to u?

 

[effie]

If it's buprenorphine not bupropion I'll edit your thread title.

Using large text looks like you are shouting!

1mg 3 times a day would not be giving you more opioid in 24 hours than 16mgs once a day. However, it may be that the effects are felt more because it is a sub-2mg dose so norbuprenorphine would be playing a role.

As I said, buprenorphine is quite atypical and people get varying results from it. It also depends if you are looking to get high or for maintenance. Don't forget that it is a strong opioid though - just because you might not get much recreational-wise from it doesn't mean that you can't overdo it, so stay safe

 

[Anon54]

I wasnt literally shouting. I dont think the neighbors would have liked that
oh I copied the name from wikipedia to try to get the spelling right lol. it re-directered me from bupe. must have got it wrong so yeah change it plz
im not asking weather it would put more of the opiod in ya system.
I want know no what dose to take to try to achieve the most euphoria.

Id assume it would simple be 32mg.

norbuprenorphine? so only the 2mg dose pills also have that?
does that higher the dose bupe u take convert to less norbuprenorphine?
explain this to me

im quitting codeine so having the bupe is a bonus there but im also trying to get some relaxation because its just one of those days i need to relax.

Just please answer these 2 simple questions!
Question 1: Would taking 32mg of bupe have the strongest effect?
Question 2: If i want to continue having those effects how long should i weight between doses?

I want a yes or no for the first answer.
& I want an approximation of how many hrs for the second question

1mg 3 times a day would not be giving you more opioid in 24 hours than 16mgs once a day. However, it may be that the effects are felt more because it is a sub-2mg dose so norbuprenorphine would be playing a role.

So does this mean only doses under 2mg convert or norbuprenorphine or something?

So can someone please just tell me. what's stronger! Is it the ceiling dose of 32mg or a dose under 8mg like 1.8mg because because norbuprenorphine "plays a role" as u put it?

isnt there anyone out there who knows this?
once I find out what dose gives the strongest effects Id like to know what "norbuprenorphine play a role" means. You could be a bit more specific.

 

[effie]

I know, I just meant that if you were debating with someone it might come across aggressive so I'd try to avoid it generally

No you misunderstood me, sorry - norbuprenorphine is a metabolite. Buprenorphine is broken down in the liver by various enzymes, and forms norbuprenorphine.

In doses of 2mg or less of buprenorphine, the norbuprenorphine that is formed in the liver attaches to receptors in the brain along with the buprenorphine, and both play a role in the opioid effects that are experienced.

In doses of greater than 2mg, the buprenorphine overpowers the norbuprenorphine and doesn't allow it to attach to the receptors in the brain, so it is only the buprenorphine contributing to the experience.

As norbuprenorphine is a full agonist, doses of 2mg or less have some full agonist action, where as at over 2mgs we only get partial agonism.

Not everything can be answered with a simple yes or no, anon, and bupe is especially complicated. Yes 32mgs is a stronger dose and would produce more pain relief. It might be more recreational in a lot of people, but others might get better effects by dosing at <2mg as some people don't find buprenorphine recreaional, where as they might enjoy norburenorphine.

32mg is a high dose and would be dangerous for a lot of people. No one should need 32mg for recreation. If your tolerance is that high, then you're unlikely to find bupe recreational at all. If your tolerance isn't that high but you've increased the dose anyway as you weren't finding it recreational at lower doses, then you are probably one of the people who won't find it recreational at any dose.

I don't understand what you mean by the best time span for redosing. If you take the right dose, you don't need to redose all day. If you're trying to determine your dose then I would say wait at least 2 hours as bupe takes a long time to reach it's peak as I said in my last post.

 

[Anon54]

OK now thanks for clearing that up for now me. i now understand how it works.
next time i'll try 1.5-2mg to see if I like Burenorphine. I'll than take another 30mg.

i dont understand why 32mg is strong. I took that yesterday & it had little effect.
what do u mean when u say "strong"
do u mean i should have been nodding & falling asleep & thowing up & stuff?
something like if i had over 100mg of oxy?

the tablets im getting are very old a crumbly. I cant see the logo.. i was told they were 8mg. maybe they are 2mgs all i can say is they're over-shaped like pics ive seen on google. im not asking for the ID of em so don worry

they are bupe though cuz they have that horrible bitter taste similar to oxy & codeine

 

[effie]

Strong as in it's analgesic (painkilling) effects. Respiratory depression too, although this has a ceiling at between 8mg and 16mg (it varies from person to person) - this means that at higher doses than the ceiling the respiratory depression does not increase too.

Bupe will never feel like oxycodone, it isn't as euphoric. I suspect that you might be someone who doesn't get a whole lot of recreational value from bupe at any dose..

Just because something tastes bitter does not mean it is buprenorphine. All opioids taste bitter, as do a lot of other drugs..

I know you took 32mg with little effect, but if you don't get much from 2mg I don't think you should take another 30mg. There is no point if 32mg didn't get you high and I'm not comfortable with someone taking such huge doses even if you were okay last time. You might have to accept that you're not going to get what you want out of it.

 

[Anon54]

umm ceiling dose of 8-16 u say?
go to bupe on wikiepdia & search for ceiling. it says it's 32mg.
so which is correct?
im getting another 4 today. i'll only take to if the ceiling is 16mg.

anyways i'll google it. sometimes wikipedia is wrong

anyway i quit codeine 4 days ago. I had a large dose of valium last night too.
im trying to quit codeine because the soluble apap is hurting my liver. I got a liver function test & i was told i cant use apap or drink. it should recover fast if i treat it well..

I have a headache & i'll be happy if the subs just get rid of my headache. (I took way to much Seroquel last night so yeah that didnt help me today)

 

[effie]

Bupe is a complicated drug!

The source I had read for the ceiling on respiratory depression said 8-16mgs but I'm off to bed so will see if I can find it or another one in the morning. The ceiling mentioned by wikipedia refers to the ceiling on all opioid effects.

So respiratory depression stops increasing above 8-16mgs and all the other opioid effects stop after 32mg. That was my understanding of it, anyway.. but I learnt about buprenorphine a while agoi and can't find my source right now (is 5.30am)..

If you took a large dose of Valium last night then some will be in your system. Be very careful with the buprenorphine and definiely do not take 32mgs, combining a high dose opioid with benzos could very easily b fatal..

Taking bupe instead of codeine is not a good idea. Buprenorphine WDs are typically significantly worse..

 

[Anon54]

oh shit i read this post to late. i just took 32mg of subs. & yeah i had 150mg of valium last night.
im not taking it JUST for quitting codeine. im experimenting with them to see if I like them or not.
I'll edit this post in an hr to let everyone know im alright & let yas know if I like them or not

 

[Anon54]

^^oh shit i read this post to late. i just took 32mg of subs *the pills are old & the sides have slightly crumbled away so maybe a couple of mg less but yeah,4 of em). & yeah i had 150mg of valium yesterday drunk with a huge sip of GFJ about midday & 150mg of seroquel before bed to help me sleep.
im not taking it JUST for quitting codeine. im experimenting with them to see if I like them or not.
I'll edit this post in an hr to let everyone know im alright & let yas know if I like them or not

dont worry though ive done other stupid things before.
taking xanax after i had already been drinking falling unconscious on the chair
taking meth & acid while being completely blind drunk. I just passed and when i woke up the acid had worn off but i was still speeding. Unfortunate because i had the same trips when I just buy themselves & it was one of my best experiences
getting drunk than drinking a bottle of robotussin (high dose of dxm) & smoking some pot. I just passed out i dont know where must have been outside & someone carried me to a bed so i just woke up somewhere i didnt know where.
taking temazepam than trying to take recreational doses of ambian. (i think I took 6 or 8 zolpidem tablets, dont know the strength but didnt realize how potent they were) led to a delirium blur. I now know they dont have recreational value
trying methadone for the first time after 160mg of oxy, burbon & coke & smoking pot. spewed every half an hr for like 4 hrs.
that's all i can think of so i think i'll be ok.
I should make a thread in drug culture about what drugs or drug combos uve dangerously tried.
I suppose Ive mixed mdma, meth, pot & alcohol together which isnt a good idea because of dehydration but I felt good... the next day though is an experience id life to forget.
lol. not really a laughing matter....
ive matured alot over time since all that. i dont drink anymore or do crazy combos. but yeah i still mix benzos & opiates together these days. & i take large doses of both

its funny though i remember when i was young & first trying drugs & when I got drunk if i just had one cone/bowl. Id be flat on the ground to out of it to even stand up. Id feel like I was falling & spinning & if i moved id wanna throw up...
i think alcohol & pot fuck up ppl more than they think. just over the years they're built a tolerance.
can u remember how much your fist cone fucked u up or how blind u got when u first drank.
& the one the really got ya wasted was mixing the 2. anyways i remember

 

[pirates_]

My homie took 1mg today. I thought since i was doing 4 mg, and felt good one mg wouldnt be to bad for him, but he got sick and threw up.. he has a very small tolarence to opies if that makes a diff

 

[Anon54]

oh shit i read this post to late. i just took 32mg of subs. & yeah i had 150mg of valium yesterday about midday & 150mg of seroquel before bed to help me sleep.
im not taking it JUST for quitting codeine. im experimenting with them to see if I like them or not.
I'll edit this post in an hr to let everyone know im alright & let yas know if I like them or not

 

[effie]

Anon, you've made 3 similar posts there, one after the other - please double check before you reply to a thread.

It is very frustrating when you ask advice then fail to listen or to even wait for the response. I hope you are okay; 32mg is a lot, as I have advised you repestedly.

As you currently have two threads on the go I am closing this one. Please do think before creating any new threads about whether it is really necessary.