Bupe: Drug Researcher Carrie John Dies Of Apparent Overdose, Boyfriend Faces Charges

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Bupe: Drug Researcher Carrie John Dies Of Apparent Overdose, Boyfriend Faces Drug Charges

BALTIMORE — A neuroscientist who studied the effects of drugs on the brain is dead of an apparent overdose and her live-in boyfriend, who did similar research, is facing drug charges, Baltimore police said Tuesday.

Carrie E. John, 29, who had a Ph.D. in physiology and pharmacology, died Sunday night, shortly after she injected herself with a solution containing the narcotic painkiller buprenorphine, according to charging documents.

Buprenorphine, known as bupe, is frequently used as a heroin substitute to treat recovering addicts. John's boyfriend, Clinton B. McCracken, told police that he obtained the drug from an online pharmacy in the Philippines, the documents show.

"The irony there is that these were individuals who were highly trained in the area of pharmacology, and they were ordering illegal, unregulated drugs from another country for recreational use," said police spokesman Anthony Guglielmi.

McCracken, a 32-year-old native of Canada, has not been charged in John's death but faces several drug charges. Police said they found a variety of drugs in the couple's row home, including nearly three dozen marijuana plants and indoor growing equipment.

McCracken is free on bail, according to the Baltimore state's attorney's office. He did not return a phone message.

John and McCracken were both postdoctoral research fellows in the anatomy and neurobiology department at the University of Maryland School of Medicine. They performed laboratory research and did not treat patients, the school said in a statement.

In a lengthy statement to police, McCracken said he had been buying drugs online and using them recreationally for the past few years. The drugs were shipped to the United States inside toys and trinkets, he said.

McCracken claimed that he received pills that contained buprenorphine, dissolved them in water and prepared a solution that John injected with a syringe, the documents show.

John immediately began having trouble breathing. She had a history of asthma, and McCracken gave her an inhaler, then called 911, the documents show. She later died at a hospital. McCracken told police he had planned to inject himself with the solution but did not.

"The defendant stated that he thought they could control the morphine and buprenorphine," Officer Dawnyell Taylor wrote in the report. "He stated that no one ever got hurt using those drugs, it must have been the batch of pills that was bad."

Bupe abuse is rare in the United States, said Dr. Donald Jasinski, chief of chemical dependency at Johns Hopkins Bayview Medical Center. Baltimore's health department has attributed one overdose death to bupe in the last two years.

A massive dose of bupe would be required to cause respiratory failure, but intravenous use of opiates can sometimes trigger a reaction that causes fluid to build up in the lungs, Jasinski said. He said the tablets obtained by McCracken may have been contaminated with another substance or may not have contained bupe at all.

An autopsy is being conducted to determine the cause of death, said Guglielmi. He said federal investigators would likely question McCracken about how he obtained the drugs but that police believe John's death was an accident.

McCracken and John received Ph.D.'s from Wake Forest University. John has published articles detailing the effects of cocaine, amphetamines and alcohol on the brains of mice and monkeys.
 
"The defendant stated that he thought they could control the morphine and buprenorphine," Officer Dawnyell Taylor wrote in the report. "He stated that no one ever got hurt using those drugs, it must have been the batch of pills that was bad."

So you're telling me pharmacology researchers were mixing bupe with morphine?
They had to have known that was useless, bupe is going to the win the receptor affinity fight every time period. I'm guessing she actually OD'd on morphine and he shot her up with bupe to try to bring her out of it.

Oh and I have never seen an online pharmacy ship stuff inside toys or trinkets, they just ship the pills in a packet or envelope.
 
If someone with a medical condition (in this case asthma) dies while taking drugs it's always the press saying drugs caused it. Was it really an overdose? Maybe she had a normal dose and maybe the asthma attack resulted from that or maybe it didn't. Another biased article. It's like reporting on a person with a history of heart attacks who catches the flu and dies when his heart finally fails and the story would read "flu kills again".

In a lengthy statement to police, McCracken said he had been buying drugs online and using them recreationally for the past few years. The drugs were shipped to the United States inside toys and trinkets, he said.

Why do people incriminate themselves? Everything you say will be used against you.
 
Bupe didn't kill anyone. I'm sure they tried to displace the morphine from the receptor sites with bupe, possibly as a last resort. Since they are drug researchers, they would know that a partial agonist would kick the morphine off the receptor. I hate the fact that they blame it on bupe, which is very difficult to OD on.
 
Opiate naive, yes. But he said that he had been using such drugs for a couple of years.
I think the scenario StaffWriter mentioned is most probable.
 
It depends on the amount of Bupe given and the receptor-binding strength of the original Opiate.
It should do.
 
hell yeah Bupe will stop the effects of a full opiate. Have you not read/heard of people that took their Subs too early and end up being thrown into instant-severe withdrawal!!??
 
Im just wondering, will injecting a person ODing with buprenorphine have the same effect as narcan? will it stop the OD?

don't forget that if your're talking about Suboxin, those have bupe AND narcan already in them.


This will get spun as a horror story about why not to use the evil over seas drugs and why you should only buy overpriced US meds, but I've got a feeling they will never release results of what was actually in those pills.. probably because it's just going to be the expected 2mg.
 
You think they would be smart enough not to inject pills, I dunno if anything besides the bupe was water-soluble though.

Shame that he got caught with the weed plants though. I'm sure he's pretty upset over everything.
 
There's some kind (or a few kinds) of filler(s) in Subutex and Suboxone that are water soluble (why it dissolves under the tongue).
 
^ good point, never thought about that. They do seem to dissolve fairly grit-free under the tongue
 
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