bupe and tramadol

[jones-in_J]

I know bupe blocks the effects of oxycodone... hydrocpdone... heroin of course


But was unsure about tramadol, i didnt know if that binds to the same receptors as bupe..... sovmybquestion is will bupe prevent youbfrombgetting high on tramadol?

 

[tricomb]

No, it does not block tramadol. It's because they're both partial agonists. Most people who need pain relief and are taking buprenorphine are prescribed tramadol alongside it, it's extremely common.

UTFSE, I got over 10 pages of hits when I entered "buprenorphine + tramadol"

 

[tentram]

yeah, i was on this combination for a while there for pain management. norspan patches with slow release tramadol, nothing for breakthrough.

generally speaking you'll find the blockade effect (with full agonists) doesn't really come into effect until around the equivalent of a 2mg dose of bupe.

 

[ErgicMergic]

Tricomb, that is incorrect.

Most people who are taking bupe at a non-blocking dosage for analgesia or maintenance are getting most of the benefit from its full-agonist metabolite, Norbuprenorphine, just as those taking tram for its opioid effects are getting the benefit from its full-agonist metabolite, O-Desmethyltramadol. Tramadol (the parent drug) is a full agonist, just a very weak one with an almost neglible binding affinity at the MOR.

The only reason O-Desmethyltramadol (full MOR agonist) works on a blocking dosage of bupe (>2mg a dose), is because it has an even higher binding affinity on the MOR than buprenorphine (competitive partial agonist) does.