Brittany Murphy Death Could be Tied to Drug Overdose

Regarding the news report in #13: since it doesn't say which scripts were not for her, we assume she was prescribed (not all at once) any combination of:

1) Topiramate
2) Carbamazepine
3) Methylprednisone
4) Clarithromycin
5) Fluoxetine
6) Hydrocodone/Ibuprofen
7) Hydrocodone/________
8) Lorazepam
9) Clonazepam
10) Propranolol

1,2,5,8 and 9 can all apply to mood/anxiety disorders. 1,2,3,6,7 and 10 can be given for migraine. 1,2 and 9 if there's seizure issues. For neuropathies, 1,2,5 and 10.

6, 7, 8 and 9 have recreational dimensions. 1 and 5 can suppress appetite. 3's an odd fit if there's a hx of diabetes. 1 and 2 can augment one another's CNS depression. 5 increases 10's antihypertensive effect.

Someone chugging Vicoprofen and barely eating would maybe have upper GI pain. Hydrocodone's sufficient for SOB. If you've exhausted your supply of Vicoprofen, and you start downing hydro/APAP, with the beta-blocker and the SSRI and the benzos and the anticonvulsants, you have hypoventillation + hypotension + clearance issues (liver and kidney) + bradycardia.
 
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seep said:
Regarding the news report in #13: since it doesn't say which scripts were not for her, we assume she was prescribed (not all at once) any combination of:

1) Topiramate
2) Carbamazepine
3) Methylprednisone
4) Clarithromycin
5) Fluoxetine
6) Hydrocodone/Ibuprofen
7) Hydrocodone/________
8) Lorazepam
9) Clonazepam
10) Propranolol

1,2,5,8 and 9 can all apply to mood/anxiety disorders. 1,2,3,6,7 and 10 can be given for migraine. 1,2 and 9 if there's seizure issues. For neuropathies, 1,2,5 and 10. 6, 7, 8 and 9 have recreational dimensions. 1 and 5 can suppress appetite. 3's an odd fit if there's a hx of diabetes. 1 and 2 can augment one another's CNS depression. 5 increases 10's antihypertensive effect.

Someone chugging Vicoprofen and barely eating would maybe have upper GI pain. Hydrocodone's sufficient for SOB. If you've exhausted your supply of Vicoprofen, and you start downing hydro/APAP, with the beta-blocker and the SSRI and the benzos and the anticonvulsants, you have hypoventillation + hypotension + clearance issues (liver and kidney) + bradycardia.
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Fluoxetine recreational?
 
From the combo of drugs in the last posted article, an OD seems kind of unlikely (although not impossible, it would take a lot of benzos and hydrocodone to make someone with a tolerance OD IMHO). I'm thinking it was probably a combo of drugs and diabetes....maybe? Or maybe she was taking more drugs than what she was scripted (most likely).
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Dank makes a good point. We all know that if it wasn't for the phenomena of tolerance alot of us would be dead. Without all the facts/autopsy one can only speculate. Possible scenario:

She has DM (diabetes). She was mentioned as experiencing changes in LOC, a major symptom in hypoglycemia. The corticosteroid (solumedral or whatever it was) she was on raises blood sugar. Stoping abruptly or tapering too fast might cause hypoglycemia. When people are hypoglycemic, the adrenals releases epinephrine to compensate for the low blood sugar which among other things, causes tachycardia, makes people jumpy/anxious, and mobilizes glycogen stores from the liver. Beta blockers, like inderal blunt this effect and mask early warning signs of hypoglycemia. Poor intake/ diet management can lead to hypoglycemia. Last, but not least, alot of the opiate pain meds have tylenol which causes liver damage in doses above 4 grams a day. The liver is a major storage area for glycogen which is converted to glucose when blood glucose drops to maintain blood levels. A shot-out liver doesn't hold alot of glycogen (as people on this board with advanced hep C can attest to). Hypoglycemia, (BS<70) especially with the prodromal symptoms blunted by beta blockers can evolve fast into serious hypoglycemia (BS<60). BS in 30s would not surprise me- and this is a serious emergency requiring promt glucose replacement. Maybe sublingual sugar, glucose gel, or sublingual glucose tabs was all she needed to stabalize her. This is all speculation of course, but I think its a possible scenario.

But saying she died from an OD, drug abuse, or related complications is easier for the average reporters mind to get around and sells more papers.

Of course those of us who have a legitimate need for these meds will suffer.

ps- I'll repeat, with abuse of vicodin, ect... its the tylenol that usually gets people, not the opiate component. This incident should be used, not as a lesson of the dangers of Rx opiates/benzos but as further evidence of the pragmaticism and neccessity of Harm Reduction
 
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She probably died from a benzo/opiate cocktail. Just a guess.
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Maybe. This cocktail doesn't usually cause one to experience shortness of breath, though. Rather, his or her respiratory rate decreases to the point that they don't get enough O2 to maintain vital functions or stop breathing all together. As far as hypoglycemia being the cause of death neurons don't do very well on fuel sources other than glucose. I think that they can mobilize fatty acids in an emergency which leads to the production of nasty ketone bodies (but my biochem is a bit rusty). The net effect of depriving the brain of glucose is the same as depriving it of oxygen- brain cells die and they do so within a short time. She obviously had alot going on health wise. The benzo/opiate cocktail might have caused her to be non comliant with her treatment regimen- which caused her death. Again, all we can do is speculate and make wild ass guesses because we don't have the full story from the press.
 
all i know is that its all speculation why dont we wait for the toxicology reports there was sumthing very nice about the lady remember seeing her in milan fashion week when she closed dsquared mens show few seasons ago oh n why do we expect stars n stuff not to have problems addictions god most of us do on this site me included goes to grab my foil n tooter
 
That sucks that Brittany Murphy died. I always thought she was right hot before she got really thin. I found in 8-mile she had a natural sexyness. In the 8-mile movie she looked so DAMN HOTT!!! Sucks that she died. RIP
 
Brittany Murphi imo was the hottest woman on the planet

she had a weird unique looking face which I love, she wasnt like the ordinary bog standard glam girl.

R.I.P.
 
glad i can post behind bighooter here, that way i know everyones taking me seriously. 8)

She was hot, and talented. She was clearly in trouble physically if she really needed all those medications. Even half of them is a lot to be on. What a tragic shame, she was gifted.

what are year for drugs, eh?
 
phrozen said:
article-1237658-07AB1E18000005DC-33_224x730.jpg

lol I hoped they looked into the contents of that baggie sticking out his pocket. :D
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lol damn yeah that looks suspiciously like a zip-lock bag.. i wonder if it was weed or something else?
 
^^Yeah, addicts never leave drugs laying around where they sleep...



8(
 
I think that non compliance, general neglect, and poorly managed multiple physical and mental health issues caused her death...not drug overdose. And I feel this distinction is highly significant. This tragedy should be used as an example for the need of prevantative medicine and harm reduction and not another rallying cry for the drug warriors. Again. pending the results of the autopsy, this is all academic and i can speculate ad infinitum.

skoat:She was hot, and talented. She was clearly in trouble physically if she really needed all those medications. Even half of them is a lot to be on. What a tragic shame, she was gifted.

what are year for drugs, eh?
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The beta blocker actors sometimes to make them public figures/people with social phobia look cool in public but your right bro with all the other drugs she was Rxed, sounds like she was a really sick girl. Horrible year for drugs and I forsee a tsunami of ignorance and hysteria heading our way.
 
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Really loved her character 'diasy randone' on girl interrupted her other roles apart from the one in spun were rather unexciting.
 
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