BOL-148 and serotonin agonism

[blueberries]

I recently read that BOL-148 while being as potent a serotonin agonist as LSD in vitro and in vivo, was inactive in testing.
If this is so would that not mean serotonin agonism isn't responsible for the effects hallucingens give?
and if its not to do with the serotonin where do they come from?
Have we been basing everything we know on a side-note to what really happens?

 

[cannibalsnail]

Just because something is an agonist doesn't mean its psychedelic. Its waaaay more complicated than that. It involves the shape of the molecule affecting how the 5HT2a receptor "unfolds" so to speak (gross oversimplification). Take LSD for example. Its a weak partial agonist for 5HT2a but is still an order of a magnitude more potent than full agonists like DOI.

 

[hx_]

I recently read that BOL-148 while being as potent a serotonin agonist as LSD in vitro and in vivo, was inactive in testing.
If this is so would that not mean serotonin agonism isn't responsible for the effects hallucingens give?
and if its not to do with the serotonin where do they come from?
Have we been basing everything we know on a side-note to what really happens?

LSD binds in so many different receptors in many ways. Too complicated to be defined by ki data. Serotonin agonism is responsible for contributing towards the effects hallucinogens give and sometimes causing/enabling them.