Body sensoric distortions of MXE/K

[Obsidius]

Hi, i got a question about the tactile sensations (physical hallucinations) certain dissociatives give you. I mainly refer to MXE, which on higher doses make my bodyparts move in different directions, hence totaly diffuse my sense of gravity and orientation on a sensoric level in my skin, giving me the illusion of floating, flying, falling, twist and turning.

I really really like that kind of mechanism and was wondering what exactly is the responsible mechanism. Is it from pure analgesic properties of dissociatives or something else?
And does anyone know of any other substance creating that exact body/tactile sensation besides MXE & ketamine?

 

[sekio]

I thought it was related to the inhibition of normal neural signalling, either antinicotinic or NMDA-blockade related. It's very common among dissociative users.

 

[Obsidius]

is there any substance that would ONLY cause the inhibition of sensoric signalling and would thereby only lead to that tactile sensation?

 

[Solipsis]

I don't think so because there is no single neurotransmitter proposed to mediate proprioception. If this were the case, there might be a chance.
On the other hand there is the possibility that a certain substance is extremely selective for a certain mutation / type of receptor that occurs in areas that control motor function.

 

[dextrodoctor]

while on dxm i could sometimes feel a sensation that i was waving my arms above my head while in reality i was holding them still on my lap.

 

[Obsidius]

I don't think so because there is no single neurotransmitter proposed to mediate proprioception. If this were the case, there might be a chance.
On the other hand there is the possibility that a certain substance is extremely selective for a certain mutation / type of receptor that occurs in areas that control motor function.

So it's not the NMDA, because 3-meo-pcp which has a way higher bindnig affinit than say MXE does not induce these tactile sensations at all. i was wondering if it might by the slight opioid affinity of MXE but opiates themself also dont wiggle my body around. might there be an additional binding involved that does not necessarily have to do something with dissociation and the psychedelic profile of these substances itself but trigger that sensoric illusions?

if so, there might be a way to isolate this kind of action? if only i would understand more about all this... i'm so fascinated about how your sensors get "detached" from normal signalling, and i think (at least it certainly feel that way) it's because they dont get stimulated by gravity anymore and "act on their own" signalling quite random sensoric inputs (that do not occur) to the brain. i literally feel like as all these tactile cells would react to magnetism and a huge magnet orbiting my body and they "turn" (vector) accordingly, while they usually would all point towards the gravitational force and when you do not move at all, and are not onto something in motion gravity is static and you dont feel their signalling at all.

can't get my head off this... i just love it, but i dont wanna take MXE more than once a month these days, so i look for the isolated agonist of this mechanism.

 

[dextroflicks]

So it's not the NMDA, because 3-meo-pcp which has a way higher bindnig affinit than say MXE does not induce these tactile sensations at all. i was wondering if it might by the slight opioid affinity of MXE but opiates themself also dont wiggle my body around. might there be an additional binding involved that does not necessarily have to do something with dissociation and the psychedelic profile of these substances itself but trigger that sensoric illusions?

if so, there might be a way to isolate this kind of action? if only i would understand more about all this... i'm so fascinated about how your sensors get "detached" from normal signalling, and i think (at least it certainly feel that way) it's because they dont get stimulated by gravity anymore and "act on their own" signalling quite random sensoric inputs (that do not occur) to the brain. i literally feel like as all these tactile cells would react to magnetism and a huge magnet orbiting my body and they "turn" (vector) accordingly, while they usually would all point towards the gravitational force and when you do not move at all, and are not onto something in motion gravity is static and you dont feel their signalling at all.

can't get my head off this... i just love it, but i dont wanna take MXE more than once a month these days, so i look for the isolated agonist of this mechanism.

this has been my obsession for a few years now

such effects from dissociative anesthetics occur due to an inhibition of sensory input, and a subsequent feedback loop that separates the conscious mind from the senses and body. Although one can obtain this from a high enough dose of MXE/KET/DXM, it is also possible to boost the effects of a low dose using sensory deprivation, which generally increases the frequency of paranormal and altered state experiences.
Sensory deprivation tanks give basically the same kind of tactile isolation which leads to the effect you are speaking of, and also they will enhance a low dose of dissociatives to give you such effects if you are looking to take less of the chemical itself.
also another interesting thing i found about sensory deprivation is "the ganzfeld". A ganzfeld, is a set of constant, predictable sensory inputs. In a typical ganzfeld experiment, the subject is placed in a comfortable chair in an isolated room, with translucent filters placed over his or her eyes, and a dim, constant light source (usually red). Sound may be absent, or white noise may be used. This sounds a lot more expensive than it usually is. the "translucent filters" could be ping-pong balls cut in two, and the white noise is provided by an AM radio.

cheers !

 

[Obsidius]

^ you are right about the sense deprivation! although i never tried a proper tank, lying in a pitchblack dark room, without music or sound and "void gazing" into the nothingness amplifies your experience immensly. it's insane what the brain forms out of the nothingness you stare into. now that you bring that up i remember a very intense body sensation the last time i void gazed in a sense deprivating setting.

i might look into the ganzfeld thing, thanks for sharing!