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Body reacts extremely different to drugs then everyone else.

U

Unlucky

Bluelighter
Joined
Apr 26, 2007
Messages
594
10 years ago during my rave party years I had a drug overdose on a cocktail of Ecstacy, MDA and Methamphetamine which resulted in near fatal hyperthermia and neurotoxic effects, I survived the incidence due to an ice bath in hospital but the neurological damage was inevitable and I ended up physically disabled and later diagnosed with a damaged Autonomic Nervous System.

I had to start life over in a new body which now had all these weird symptoms due to the neurological damage. Along with my vitals and other Autonomic functions my body temperature control had totally messed up resulting in high fevers everyday which has continued for the past 10 years. I now spend a lot of my time in front of the cooling system trying to lower my temperature and wear an cooling ice vest when I go outside. My sexual function is also messed up and since that horrible day day I now find I go into painful twitching and violent muscle spasm whenever I become sexually aroused. The worst part is that my brain chemistry is all messed up and it reacts very differently to all drugs that act on my autonomic system making it almost impossible to be anesthetized due to the risks or take opiates, depressants, stimulants, SSRI's and other medicinal drugs without experiencing odd hypersensitivities and adverse reactions.

Every class of drug results in its own unique adverse reaction, for example when I take a measly 5mg dose of Oxycodone for my chronic pain I end up with muscle spams, hyperthermia and not being able to sleep that night and it acts almost like a stimulant. This is where it gets real weird....If I engage in sex even 5 hours after taking the oxycodone I find myself being able to last without ejaculating for up to a ridicilious 6 hours :|.....

6 hours of non stop sex from a measly 5mg oxycodone, I'm not complaining about it, sure its fun until it becomes painful and I keep getting flaccid but I'm more bothered that this whole thing is an indication that something is very wrong with me. The crazy thing is its not just the oxy that causes me to last this long, its more so the combination of the oxy on my disrupted brain chemistry because I find that within the first 10 minutes of sex I am ready to ejaculate but soon as my temperature begins to rise, soon as that dopamine begins to release and adrenalin kicks in then bang I get an extra bonus 6 hours and the ejaculation feeling subsides the longer I keep going. Then I go into this crazy loop cycle where the longer I have sex the more my vitals gets messed up and the more my vitals get messed up the longer I can last but its all due to the additional factor of the oxy which is a piggyback from my disrupted brain chemistry to feed off, and then even after the oxy has warn off I am so fucked up by my own hyperthermic and overloaded brain chemistry from the initial effects of the oxy that I can still keep going for many hours.

Then if I re-dose with an additional 1 mg when I feel like I'm ready to cum by the end of the 6 hours then that 1mg somehow resets the clock all over again keeping me going for another few hours which makes no sense to me. How can such a little dose of oxycodone last well beyond 8 hours and how can an extra 1mg redose make such a difference, and how can oxycodone have such a drastic effect on my sex drive even many hours after I take it ? I have all these questions no one seems to be able to answer.

I have been told all the abnormal symptoms are a result of disrupted brain chemistry such as excessive and insuffcient release of chemicals such dopamine, seretonin, norephedrine, etc but I want to know more.

Furthermore the other weird thing is that I have been on oxycodone on and off for almost 2 years yet I am still unable to go above a 8mg liquid dose, soon as I increase it from 8mg to 9mg I have an adverse reaction, so even a 1mg dose makes a difference even after 2 years of using. Then there is tramadol which takes 5 hours to take effect after ingesting , I know its a pro drug but 5hours seems ridiculous. I have had a cytochrome p450 liver function test which came back normal so its not that.

All these weird things are happening to me and no one can explain it, my Neurologists did a test where they gave me a 10mg dose of Oxycodone in hospital and monitored my vitals and they were stunned by all the weird adverse effects I had and the disruption it caused in my vitals. If only they saw the effects of sex on it as well 8)

Then there is cannabis which causes all these weird gastrointestinal symptoms unlike anything mentioned in its side effects, so basically my body reacts extremely differently to drugs then everyone else and it NEVER used to be like this before I fried myself from that drug overdose 10 years ago. I would just like some help from you guys on any theories or fixes you can throw my way.

Thanks.
 
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Damn u are very unlucky. It sounds like your OD may have caused a synaptic pathways much like the ones attributed to split personality but instead in the reward portion of your brain. these pathways occur when an overexposure to a substance causes your body to switch from negative feedback to positive feedback. Essentially in most people the production of dopamine and seratonin inhibit the production of more dopamine and seratonin past an equilibrium level without some kind of external stimulus like sex or drugs, however in your body it appears that the release of dopamine and seratonin trigger the production of more of these chemicals and cause the cascade effect u experience. I do not know exactly how this switch occurs, and I have only heard of it in stress hormone and adrenaline response, never with reward pathways so i cannot be sure i am correct. Did ur doctors give you any ideas on what they believed was causing this?
 
thesomoan said:
Did ur doctors give you any ideas on what they believed was causing this?
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After years of evaluation they concluded that the abnormal symptoms are directly a result of generalized damage to the hypothalamus, the (5HT) terminals in the brain and other neurotransmitters and the unusual symptoms I'm having are due to loss of functional neurons. They also agree that during the overdose the severe hyperthermia damaged areas in the brain particularly around the region of the the preoptic area that controls thermoregulation, it is also believed some of the same damaged areas cross over with sexual repsonse, as I experience a very closely intertwined connection between sexual function, temperature control and the areas that are stimulated by a psychoactive drug response.

The physical disabilty I developed during the overdose has been diagnosed as Dysautonomia and Autonomic Neuropathy (Autonomic Dysfunction) and one of the textbook causes for this is listed as chemical exposure and neurotoxic effects.

I am finding that sex and drugs seems to both act on the same region and both have a major effect on my body temperature and both also causing similar responses and unusual muscle spasms, distrupted vitals but when I combine the two (sex and drugs) then it all amplifies.

This is going to sound ridiculous but whenever I engage in sex on oxycodone I have a bucket of water next to me with wet towel which I constantly dip into every 10 minutes and wrap around my head because there is so much heat radiating from my skull during sex and in fact it feels like my brain is overheating and even the towel seems to dry pretty quickly within 10 minutes so I constantly have to reapply.
 
atara said:
How does alcohol affect you, or ketamine if you've ever tried it?
Click to expand...

With Beer I get flushed, hot face increased temperature, high blood pressure and all of this before I even drink enough to get drunk. With spirits like vodka its much worse, one shot makes me very ill and not in a drunk way, more a disruption in my vitals and again feverish and feeling like death, never tried ketamine though.
 
The other thing I want to add is that oxycodone seems to be an unstable compound for me, more so in its response, for the first whole year when I was taking it I was having varied reactions to it, like one day it would cause hospitalization due to increased high blood pressures and rapid heart rates but then the next day I would be hospitalized again but this time for the opposite reason for dangerously low blood pressures and low heart rates and then on another day I would only develop the hyperthermia response from it without it effecting my heart rate or other vitals, and then other days it would be a combination of all symptoms, some days I would be able to almost tolerate it without any side effects especially when I took a morning dose as opposed to a night time dose which caused more problems due to it having some odd connection and changes in hormone levels and altered brain chemistry throughout the day from a bio-rhythm.

It seems the combination of different adverse effects are too many to list and vary from day to day, I am puzzled by its random, inconsistent and unpredictable response, anyone care to explain ?
 
Hmmm.... once again i am really speculating here but since u appeared to have consumed all amphetamines, which promote synaptic creation, perhaps your body lost certain neurons and receptors from the sheer neurotoxicity of the cocktail you took, and then conversely formed new connections in parts of the brain that would not normally be connected. This would seem to explain your physical symptoms, the connection of seemingly unrelated responses which are geographically close in the brain, and even the random nature of your symptoms, as certain conditions would be required to stimulate the pathway which connects the drug/activity to the adverse effect. Once again just a thought
 
Thanks to all of you that responded, and yea the serotonin syndrome possibility has come up several times over the years both as a trigger and ongoing response during the adverse effects to drugs but I have no way of knowing for sure.

I have to ask this question again if anyone missed it...What would cause a drug such as oxycodone to vary greatly in its response ? even when I have been using the same dose everyday.
 
As i said it could be because you have formed erroneous synaptic connections which means that other factors, like your temperature, emotions, location etc, might govern your response to certain stimuli.
 
Sorry to hear about your troubles -- that's a really unfortunate set of circumstances.

I've never overdosed on anything except DMT (repeated ayahuasca doses adding up to 35 grams mimosa hostilis not active for 5 hours were suddenly released from gallbladder after eating), but my tendency to overheat seems to have gotten worse over time. Maybe it's my aMT and amphetamine use. Thing is I don't have any of the problems with hunger or sleeping or fatigue that usually come with damage to the hypothalmus.

You probably know about it already but they sell those scarves that you keep in the freezer and wrap around your neck to cool the blood. That might help a little. Have you tried medications meant to break fevers to help with the overheating?
 
thesomoan, that is a good theory I will mention it to my Neurologist to see what he thinks.

psood0nym. I actually have one of those scarves filled with a dry gel which you soak in the water and it expands then you put in the freezer. It works wonders. The only meds I tried for fevers is aspirin and clonodine which women use for hot flashes, although I am a guy, it was supposed to be experimntal therapy, either meds failed to treat my fevers.
 
That's good. You might also try wrapping them around your wrists. Lots of blood flows close to the surface there, like the neck, so you could probably almost double the cooling effectiveness of one scarf that way. I've run my wrists under a hose in summer for a minute to cool down fast. It works pretty well. If you used them "preemptively" it would probably work the best.
 
thats fucked man i will never take stimulant combos lightly after reading this. mind you the only drugs i like to mix are psychedelics. i dont think upper + upper or downer + downer is very fun
 
I'm just personally suprised that with such severe adverse reactions to oxycodone the doctors would still prescribe it when its use results in hospitalization. There are so many other drugs out there to treat pain especially if your LFT came up good. The ejaculation thing is a somewhat common reaction to opiates so it's not unique to you but of course most individuals need a significantly higher dose. I'm also suprised they haven't put you on a calcium channel blocker or any of the ARBs since those would probably help with the blood pressure/overheating better than would clonidine. How do you respond to caffeine just out of curiosity or any other stimulants if you've used any since the incident. Even ones as minor as phenylephrine, pseudoephedrine, or even DXM in non-recreational doses.
 
Hi syndeusys, you have raised some good points. Oxycodone was one of the last opiates that I trialed in a line of pain relief drugs. When it became apparent that my body was rejecting opiates my doctors embarked on a mission to find one that I could tolerate and in the process I trialled: codeine, oral liquid morphine, hydromorphone (dilaudid), tramadol, fentanyl patches for which all caused me adverse reactions, eventually I settled on oxycodone oral liquid only because I had some success desensitizing myself to it in very small doses like 1mg - 2 mg so I pursued it.

I am actually on 2 types of betablocker which is essential to treat my Autonomic Dysfunction, without these betablockers I cant even stand up or get out of bed without my heart and blood pressure flipping out due to effects of gravity and postural changes on my blood which the blood vessels fail to vasodilate and vasoconstric accordingly due to adamaged Autonomic Nervous System, to control this I use "metoprolol tartrate" and "moxonidine" which is more of a new generation centrally acting antihypertensive drug and selective agonist that causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure. Compared to the older central-acting antihypertensives like clonidine , moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity. But unfortunately none of these are able to control the fevers associated with the thermoregulatory dysfunction.

I can no longer take cold and flu meds that contain pseudoephedrine, the last time I took one I spent the entire time under a cold shower trying to combat hyperthermia and heart was very irregular, overall it was a very unpleasant experience, caffeine on the other hand just causes rapid heart rates with some facial flushing, gone are the days when I could pop a few pills, snort a line and dance my ass of till dawn at a rave :(
 
Yea that was actually the drug they used in the ER during the overdose that day which left me disabled, I think it was the Dantrolene and ice bath that saved my life, but none of my specialists ever mentioned using it for ongoing fevers or hyperthermia, perhaps maybe because it has a lot of side-effects for ongoing use?
 
Have you tried keeping a sort of diary with info like what you've eaten, taken for medication various symptoms throughout the day and countermeasures you've taken as well as the time of day? i have a hunch that you may be consuming foods and possibly beverages that affect you and how your meds affect you.

Have you tried ibuprofin, ketoprofin, naproxen, or APAP for the fevers?

Have you had routine blood tests for electrolyte and hormone levels and additional tests for an immune-response to opiate drugs.

Sorry if this is a weirdish personal question (u don't have to answer if you don't want to) Do you overheat because your body doesn't sweat much or at all anymore? Does the overheating seem to start before, during or after drug-induced muscle spasms?

Has your doctor tried benzos for the spasms?
 
Sorry to poop on this thread, but this has got to stop. This is the hundred and tenth "my body has adverse reactions" thread that this guy has made. Sorry dude but this is in your head. Its an anxiety driven response to an overdose. A scary and life changing event that can literally make you think that this or that or this or that or blah blah blah is happening or is going to happen. Its your body saying STOP. I think now more than ever your addicted to people telling you "aww man my heart goes out to you." Or "Dude that totally sux bro! Keep your chin up bruh I hope you get through this!" I for one am not interested in humoring this garbage. Your not going to find the answer to your 'problem' here on Bluelight. If you still want to try to cop a buzz fine, but for gods sake don't create another thread on your adverse reaction symptom hyperthermia (ANXIETY) to it.
 
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