I'm looking for good medication to keep BP/HR in safe range during methamphetamine high.
I've come across several scientific publications. In summary:
I guess I could miss something. Please correct me if I'm wrong at those points or if you have to add something to it. Any suggestions appreciated.
Although "unopposed alpha stimulation" is just theory, I would like combination of both beta and alpha blockers to be used.
My main question is:
Is taking some beta-1 blocker like Nebivolol in combination with some alpha-1 blocker a safe way to keep BP and heart rate in normal range during methamphetamine effects/post-effects? Is it as safe as Carvedilol as long as both blockers (beta and alpha) onset/half-life times are relatively equal and should the onset/half-life times be exactly equal for the combination to be safe?
Here are some of publications my points are based on:
Edit: publications links added
I've come across several scientific publications. In summary:
- There is hardly any evidence that "unopposed alpha stimulation" phenomenon from taking beta blockers alone occurs in practice although some medics avoid using beta blocker without alpha blocker because of the theory.
- Combo medications (beta + alpha blockers) available in my area, like Carvedilol, do not lower BP significally. Larger doses just lower heart rate even more while BP is still high. For Carvedilol particularly it seems to be true.
- Beta-1 blocker is what is more effective to keep BP safe in comparison to non-selective/beta-2 blockers. Also, most adverse side effects of BP medication come from beta-2 blockade effects, not beta-1.
I guess I could miss something. Please correct me if I'm wrong at those points or if you have to add something to it. Any suggestions appreciated.
Although "unopposed alpha stimulation" is just theory, I would like combination of both beta and alpha blockers to be used.
My main question is:
Is taking some beta-1 blocker like Nebivolol in combination with some alpha-1 blocker a safe way to keep BP and heart rate in normal range during methamphetamine effects/post-effects? Is it as safe as Carvedilol as long as both blockers (beta and alpha) onset/half-life times are relatively equal and should the onset/half-life times be exactly equal for the combination to be safe?
Here are some of publications my points are based on:
- Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans
- The unopposed alpha-stimulation phenomenon: What is the role of beta-blockers?
- Methamphetamine Toxicity
- The use of intravenous labetalol in the setting of rapid atrial fibrillation secondary to methamphetamine use
- Nebivolol (Bystolic), a Novel Beta Blocker for Hypertension
Edit: publications links added
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