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Bladder irritation from certain psychedelics.

Transcendence

Bluelighter
Joined
Jul 19, 2006
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I've consistently experienced a constant and unshakable urge to urinate while under the influence of two seemingly unrelated psychedelics in particular: 2C-T-7 and aMT. It's quite annoying and rather ruins the experience. The feeling does not persist after the drugs have run their course. None of the other 2Cs or tryptamines (or any drug for that matter) seem to have this effect on me.

So is this mechanical (i.e. the metabolites of the chemicals cause tissue irritation) or receptor based? Both 2C-T-7 and aMT have MAO inhibition activity, but I was under the impression that aMT's MAO effect was very weak.
 
2C-T-7 caused the opposite for me... I couldn't piss for the life of me. It was like I was on a speedy roll...

AMT same thing.

Do you have any kidney issues? I believe they're both excreted in urine. Obviously you're not drinking alcohol on those so I don't know what would explain you getting that effect. They both just make me vomit at worst and then I can't pee even when I feel like I have to.
 
I get the same thing with mushrooms. Quite annoying. I remember many times peeing then as soon as I'm finished and haven't even packed up yet i feel busting to go again. A friend (male) used to sit on the toilet for ages rather than go back and forth all night.
 
2C-T-7 caused the opposite for me... I couldn't piss for the life of me. It was like I was on a speedy roll...

AMT same thing.

Do you have any kidney issues? I believe they're both excreted in urine. Obviously you're not drinking alcohol on those so I don't know what would explain you getting that effect. They both just make me vomit at worst and then I can't pee even when I feel like I have to.

We might be describing the same thing. I feel like I need to pee, but I can't. I think it's not because my bladder is full of urine and I can't let it out, but because my bladder is empty and the sensation is there. I've had blood work done several times over the last few years for various reasons and my kidneys/liver are always functioning perfectly.

I know that sometimes this feeling is caused by uric acid crystals in the urine, which have a variety of causes but in young people is usually caused by dehydration. Sometimes they precipitate before a kidney stone arises. I don't drink alcohol very often, and I certainly don't drink on T7 or aMT. I do however, have a habit of not drinking enough fluids.

So dehydration can certainly cause this sensation, but I don't think it's the case with these two drugs given how this happens 100% of the time on T7 and aMT, and 0% of the time (for me) on 2CE, 2Ci, 2CC, DOx, LSD, mescaline, LSA, DMT. I've heard other people report similar sensations on 2CE before, but 2CE has always been kind to me physically.

On mushrooms I've often experienced the sensation of having wet my pants or being in danger of doing so because everything generally feels wet to me on mushrooms. This can cause me to go back and forth to the bathroom many times, but I haven't experienced the intense, incessant bladder irritation feeling on mushrooms.

Of course, it could be entirely psychological given the nature of these "mind-manifesting" drugs.
 
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