N&PD Moderators: Skorpio
Black Cohosh for a Hydro Sub?
tramadol32
Greenlighter
I'm out...and I've been seeing these threads (on different sites) of how black cohosh extract liquid is about the same effect as 10mg of hydrocodone. Papa Verine said this on Opiophile. What do you guys think? Any other herbs out there, besides the obvious Kratom, that bind to opiate receptors?....and please dont start talking about Immodium! Lol!
sekio
Bluelight Crew
It's probably about as active as ... what was it... myrrh terpene extract. That is to say, not very.
Binding to opiate receptors != opiate activity. See also: naloxone.
tramadol32
Greenlighter
I'm confused with naloxone. Can you take this like you take any other? From what I read, its used as something to keep you from overdosing. Sorry, I'm about the least educated person in this forum, and I don't know much about this.
sekio
Bluelight Crew
Drugs can bind to receptors but not cause the receptors to "activate". Hence drug binding to receptors is only part of finding active compounds, and drug binding doesn't automatically mean a working drug.
Morphine, for instance, binds to and activates mu-opiate receptors. Naloxone binds but does not activate the receptors, resulting in a 'loss' of opiate effects.
It's like keys and locks. Some keys won't fit in a lock. Of the keys that do fit, only a few will cause the lock to turn and open.
To the best of my knowledge, Papaver somniferum and Mitragyna speciosa are your best bets for natural opiates. There are definitely other compounds but they are either expensive exotic botanicals or not very selective. (Black Cohosh is not a real opiate for this reason. It acts at estrogen receptors and other things with a higher affinity than mu opiate.)
egor
Bluelighter
Yellow horned poppy and glaucine may be worth checking out
negrogesic
Bluelight Crew
Answer: no
tramadol32
Greenlighter
I have tried the black cohosh extract 1 oz. I evaporated the alcohol, and still had no effects of an opiate buzz. A slight head change yes, but no opiate buzz
Limpet_Chicken
Bluelighter
As far as I know my herb lore, and that is quite well I would say, black cohosh is primarily used for women's problems. It is estrogenic, and has other effects that counter bone loss in people prone to that, such as osteoporosis, and joint problems to a degree also.
Not really a man's herb, and not suitable for the intended purpose at all. May cause hepatotoxicity also, potentially.
