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  • N&PD Moderators: Skorpio

Bk-bdb

He means the beta-ketone of BDB or 'J'. 2-AMINO-1-(3,4-METHYLENEDIOXYPHENYL)-1-BUTANONE maybe? Not sure what it'd be called in IUPAC format.
 
Yes, it's possible. The synthesis would be very similar to that of MDC. I can't really tell you what it would feel like, but I will say that I'm not really dying to try any.
 
It would be possible, but AFAIK it would have the same problem as other primary amine cathinone-analogues, of dimerization and stuff... probably wouldn't be a very stable molecule.
 
Coolio said:
He means the beta-ketone of BDB or 'J'. 2-AMINO-1-(3,4-METHYLENEDIOXYPHENYL)-1-BUTANONE maybe? Not sure what it'd be called in IUPAC format.
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Yes, that's what I meant. I didn't know there was a similar chem with it's abbreviation.
 
In IUPAC, it'd be 2-amino-1-(benzo[d][1,3]dioxol-5-yl)butan-1-one, but that's (Coolio's quote) still recognized by ChemBioDraw as the correct structure.

Shit, beta-keto-J should be called Joan. Or Jone.
 
The interesting thing about bk-BDB will stem from the fact that BDB itself feels like indanylamphetamine - a serotonergic-only stimulant. Usually when you turn an amphetamine into its beta-keto counterpart, it loses much of its ability to effect serotonin and becomes more effectively dopaminergic...
 
Coolio said:
The interesting thing about bk-BDB will stem from the fact that BDB itself feels like indanylamphetamine - a serotonergic-only stimulant. Usually when you turn an amphetamine into its beta-keto counterpart, it loses much of its ability to effect serotonin and becomes more effectively dopaminergic...
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I don't believe that indanylamphetamine is 'purely serotonergic' considering that it substitutes for MDA but not 3-methoxy-4-methylamphetamine (which is purely serotonergic).

This indanylamphetamine, (also called IAP, 1-(5-Indanyl)-2-aminopropane or 5-(2-aminopropyl)indane) is an analog of MDA, but with both oxygens in the methylenedioxy bridge replaced by methylene (CH2) units. It has been shown to not be a serotonergic neurotoxin, and is active at 0.2 mg/kg in Nichols' lab rat tests, compared to 0.8 mg/kg for MBDB. However, the lab rat results show that the effects should be somewhere inbetween MDA and MBDB, as it doesn't fully substitute for the purely serotonergic compound MMA (3-Methoxy-4-Methyl- Amphetamine), but does share some of the dopaminergic effects of MDA. Further animal tests showed that IAP does not substitute for amphetamine, so the compound is not a particular stimulant either. IAP is also one of the most active serotonin-releasing agents known so far, together with the 4-iodoamphetamine and 4-methylthioamphetamine (4-MTA). However, 4-iodoamphetamine is a serotonergic neurotoxin, and 4-methylthioamphetamine has also shown signs of toxicity, as it also exhibit MAOI properties. This together with is serotonin-releasing properties, makes it prone to give a serotonin syndrome in people taking it, and several 4-MTA related deaths has been reported. The same cannot be ruled out for IAP, so caution is advised in any human testing of this compound. The animal test results suggest that the active dose is somewhere between 20-40mg. In October 1998, there were news reports that the compound had been seized together with other ecstasy-like compounds in South Australia (possibly Adelaide), confirming that it has been manufactured in clandestine laboratories there.
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Given the above study, do we have any idea which similarities between MDA and IAP foster substitution? Would it have to be increased dopaminergic release? What about more direct 5ht2a action?

Basically, does the study to which the above abstract refers contain data showing dopaminergic activity in IAP more directly?

ebola
 
Have you heard from anyone besides fast and bulbous? ;)
Not saying that he's mistaken, but with data limited to an N of 1, who knows if it's just idiosyncratic.
 
crowbar said:
I've heard that taking dextroamphetamine and IAP at the same time results in an experience identical to MDA
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That would make sense in terms of the "feeling" of the experience, but I'm not sure if that combination would be identical to MDA in terms of it's psychedelic effect.
 
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