Jakeperson
Bluelighter
Any one IV'd this?
Any one IV'd this?
LOL, this is truly legendary, especially if taken out of context.I've even eaten cheese on it with no problem.
Abstract
The ability of 4-chloroamphetamine, 4-bromoamphetamine, and 4-fluoroamphetamine to deplete brain 5-hydroxyindoles and some pharmacokinetic properties of these drugs were compared in rats. Half-lives of the three compounds in rat brain were 3.7, 4.4, and 5.7 hr, respectively for the 4-fluoro, 4-chloro, and 4-bromo amphetamines. The tendency of the drugs to be associated with paniculate material in brain homogenates or to prefer an organic versus an aqueous phase in vitro varied in the order 4-bromo > 4-chloro > 4-fluoro. This order of activity also applied to the inhibition of monoamine oxidase in vitro. All three 4-haloamphetamines reduced the activity of tryptophan hydroxylase and lowered the levels of serotonin and 5-hydroxyindoleacetic acid in whole brain initially. With 4-chloroamphetamine and 4-bromoamphetamine, the depletion of brain 5-hydroxyindoles lasted for at least a week. 4-Fluoroamphetamine, in contrast, lowered serotonin and 5-hydroxyindoleacetic acid levels only for short times (2–6 hr) after drug injection, and 5-hydroxyindole levels were essentially back to normal within 24 hr. Prior treatment with an uptake inhibitor prevented the serotonin depletion by all of the haloamphetamines, indicating they all required the membrane uptake pump for entry into the neurone. The effect of 4-bromoamphetamine, like that of 4-chloroamphetamine, could be reversed by subsequent injection of the uptake inhibitor after short periods but not after 24–48 hr. The failure of 4-fluoroamphetamine to produce a long-lasting depletion of brain serotonin like that produced by 4-chloroamphetamine or 4-bromoamphetamine may reflect the inability of the fluoro-compound to be metabolized in the same way as the other haloamphetamines.
Oh make fun of me if you want, life is too short to be butthurt!LOL, this is truly legendary, especially if taken out of context.
Perhaps it should be mentioned that amphetamines are a bit (like a factor 100) more worrisome then tyramine, which is - by the way - only present in significant quantities in certain types of (overaged) cheese. (This is serious, no intention of mockery or anything here)
Thanks for the link. It doesn't do anything to serotonin, but there isn't mention of dopamine. I've combined Dexedrine, Selegiline and 4FA, and its pleasant, but nothing more than a feel of amphetamine. No empathy at 10mg dosage.This one is non-neurotoxic in rats, I wouldn't worry so much
Thanks for the link. It doesn't do anything to serotonin, but there isn't mention of dopamine. I've combined Dexedrine, Selegiline and 4FA, and its pleasant, but nothing more than a feel of amphetamine. No empathy at 10mg dosage.