I can't comment on any cross-tolerance with the NBOMes, but there is likely at least some degree of cross-tolerance between 4-fa and mdma due to significant serotonin release induced by both substances, obviously much more with mdma but 4-fa still have clear serotogenic qualities.
IME with 4-fa and methylone, if you use 4-fa once or twice in the week leading up to a methylone experience then no real cross-tolerance is apparent, and even using 4-fa a few hours before the methylone doesn't diminish the latter's effects.
On the other hand, daily or semi-daily 4-fa use or using it for a week or more without a break would surely diminish the effects from an MDMA experience due to serotonin depletion.