shady4091
Bluelighter
Loperamide for withdraws is a huge win. What I don't fully understand though, is how does it work so well on every symptom (even in smaller doses) while still not crossing the BBB in sufficient quantities? Is its activity on the intestinal receptors enough to reduce or even eliminate withdrawal from other CNS opiates?
I've been pondering something else about Loperamide and possible negative side effects of everyday high-dose use. A regular dose is 2-4mg right? So that dose is enough to stimulate the opiate receptors in your intestines etc. enough to cause constipation. Therefor 2-4mg would be a "dose" for your intestines. Now obviously none of that (or no negligible amount) is making it through to your brain in the end. I have; however, taken a dose of 86mg once, a couple years ago, just out of sheer curiosity and I noticed definite CNS effects. Warm body feeling, heavy and sedated and slight euphoria. It wasn't extreme but as I understand that's less than a "recreational" dose, especially since I was already addicted to Codeine. Even so, it was far beyond placebo.
So 86mg. Theoretically, only a tiny fraction of that is actually making it through to my brain. It would be something small, say 0.5mg for the hell of it. It's obviously a very "potent" opioid (Still assuming 2mg is a "dose"). Taking this dose everyday may not cause negative effects any worse than that of everyday, other opiate use but you have to think of how huge of a dose that is for the receptors in your intestines, which are receiving the full amount. It's up to 43 times a regular "dose", of a very potent opioid. Could problems not arise from that alone? I'm not talking about excessive constipation which I don't see as any worse than other potent opiates, I'm thinking more like "over-working" those receptors so-to-speak. Problems like this may not emerge for quite a while.
I'm just speculating here, someone can absolutely correct me if I'm wrong.
I've been pondering something else about Loperamide and possible negative side effects of everyday high-dose use. A regular dose is 2-4mg right? So that dose is enough to stimulate the opiate receptors in your intestines etc. enough to cause constipation. Therefor 2-4mg would be a "dose" for your intestines. Now obviously none of that (or no negligible amount) is making it through to your brain in the end. I have; however, taken a dose of 86mg once, a couple years ago, just out of sheer curiosity and I noticed definite CNS effects. Warm body feeling, heavy and sedated and slight euphoria. It wasn't extreme but as I understand that's less than a "recreational" dose, especially since I was already addicted to Codeine. Even so, it was far beyond placebo.
So 86mg. Theoretically, only a tiny fraction of that is actually making it through to my brain. It would be something small, say 0.5mg for the hell of it. It's obviously a very "potent" opioid (Still assuming 2mg is a "dose"). Taking this dose everyday may not cause negative effects any worse than that of everyday, other opiate use but you have to think of how huge of a dose that is for the receptors in your intestines, which are receiving the full amount. It's up to 43 times a regular "dose", of a very potent opioid. Could problems not arise from that alone? I'm not talking about excessive constipation which I don't see as any worse than other potent opiates, I'm thinking more like "over-working" those receptors so-to-speak. Problems like this may not emerge for quite a while.
I'm just speculating here, someone can absolutely correct me if I'm wrong.
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