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Beta-keto NBOMe's

dip12

Bluelighter
Joined
Feb 4, 2012
Messages
82
This may appear a chem wank but I do have a few serious points so I am hoping it will be accepted:

1) Does anyone know if these have been investigated? (any info at all scientific or otherwise) It seems perfectly logical considering the dragonflys, flys, TCB-2 and recently read even a tryptamine have had their corresponding NBOMe's explored.

2) N-substitution was talked about a lot (I believe pre-NBOMe's) in reference to beta-ketones, I.e there was long discussion about how simple unsubstituted PEA's (e.g 2c-b) can not have their corresponding beta-ketone explored because without N-substitution they are very unstable and therefore problematic if not impossible. NBOMe's turn the annoying necessity of HAVING to have a N-substitution for stability in to actually optimising 5HT2a agonism etc.

3) Although not a viable scientific point, I would imagine the bk-NBOMes would be legal in many places as the corresponding PEA would not be a impurity (as has been found the case recently with normal NBOMe's). Anyone know if the (at present purely theoretical) bk-2-c-b is covered by UK cathinone catch'all?

It would also be of great interest to finally have a beta-ketone psychadelic analogue (if I am correct so far this has not occurred? The closest I am guessing is ecstasy type compounds lying somewhere in between stimulants and psychedelics i.e methylone/methylmethcathinone etc etc)

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1) Not to my knowledge, and i have yet to see a bk-version of a phenethylamine psychedelic (2C-X or DOX)

2) Some cathinones exist as the primary amines, but most are N-alkylated. The N-benzyl should increase 5-HT2A affinity but the 2,5-dimethoxy-4 halo/alkyl substitution pattern will probably negate most of the monoamine reuptake inhibition/release exhibited by the more common cathinones

3) no idea

The closest i've seen to bk-psychedelic PEAs is beta-Methoxy-DOB/DOI which were published by Glennon
 
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