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  • N&PD Moderators: Skorpio

beta-isopropylaminonaphathalene, aka Naphthylaminopropane

I did notice the 2C agonism, but what about being stereoselective in synthesis for the s-NAP? Wouldn't that produce something (potentially) without 2C agonism? Aside from that I didn't see any major downsides aside from perhaps low potency (though that suggests it would be just a question of dosage, unless there were side effects at higher dosage or other affinities made themselves known)
 
2C-* feel to me at least to perhaps be partial agonists at 5HT-2C, assuming you are correct that they bind there, though it could also be due to some adrenergic activity the 2C's have, so I cannot tell you from sensation alone exactly
 
Has anyone actually tried this compound? Okay, so you all have concluded it will likely have no recreational function, but do you think it could be a viable replacement for amphetamine for productive purposes?
 
this drug has pretty high EC50 values for 5-HT, DAT, and NAT(esp.5-HT); but having high affinity for 5-HT2c(full agonist) would likely induce anxiety. however its strong 5-HT release could possibly counteract the anxiety and induce empathogen effects(esp. combined with strong DAT release).

this drug can't really be expected to be anxiety inducing like mCPP, as mCPP does not release DAT- it acts mostly as a 5-HT2c agonist, selectively releases 5-HT, and releases NAT. pretty much all of mCPP's mechanisms set up for causing unwanted effects.

beta-isopropylaminoaphathalene(from what i'm hearing) sounds worthwhile, at least more than mCPP(although i've had a few positive experiences with mCPP- its like the "MMDA of the piperazine world", with BZP being the "MDMA of the piperazine world").
 
How about N-methylation to reduce the 2C affinity, and using the S-enantiomer as already mentioned.

I haven't tried it, but did try 3-methoxynaphth-2-ylisopropylamine (to the subject compound as MMDA-2 is to MDA) and didn't like it. Was just stimulating, and not in an interesting way.
 
I will have access to a small quantity of this, but I'm feeling a little apprehensive about dosing given the lack of anecdotal in-vivo info.
 
I am quite interested in trying amounts of the title compound. I wasnt impressed by the controversy over whether or not this drug causes cancer. People realize naproxen has a naphthyl ring right, and doesnt cause cancer. Cancer is no laughing matter.

I would hazard to say that "they're all highly abusable" although in the case of PAL-287 I was actually impressed by its potency, reported non-toxicity, and its alleged non addictivity.
 
Thread NECROMANCY! :P

I wonder if there have been any updates to speculation about this compound. It seems like it's now known that there are pretty viable psychedelics that are decently strong 5ht2c full agonists (namely, various DOxs, and arguably several 25x-nBOx compounds, though the latter are somewhat selective for 5ht2a agonism). There are also plenty of psychedelics with highly significant 5ht2c partial agonism that are just dandy. Also, the binding affinities and EC50s suggest strong, broad-spectrum monoaminergic release, which I would imagine to ameliorate the ugliness of more selective 5ht2c agonism. I don't think that the kiss of death of the piperazines applies, as those most prone to anxiogenesis appear to be broad-spectrum 5ht agonists with moderate selectivity for 5ht2c and direct adrenergic effects.

Have any subjective reports come out?

Man they should have tried that with the piperazines a long time ago.
Click to expand...

I dunno...piperazine SAR seems pretty different from that of phenethylamines.

ebola
 
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