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beta-DIDEUTEROPHENETHYLAMINE

I

ingo_1978

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May 20, 2006
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Do you think that any interesting phenethlyamines could come from adding a beta-dideutero to amphetamines, MDMA, 2C-x's. I'm pretty sure this would not come under the UK phenethylamine act.

There seems to be a promising mescaline version of this in Phikal
 
for one thing, isotopically pure reagents are incredibly expensive so these compounds would be hundreds of dollars per mg

second, the study is mainly for studying metabolic processes, not change in effect. there could be a 10-20% increase in duration, if any at all.

third, that entry seems to show there is no distinguishable difference between M and beta-D or 4-D...
 
I think his idea is to avoid analogue laws by deuterating the compound. I'm pretty sure that the law would see each compound equally.
 
Most elements are expensive to get isotopically pure samples of, but hydrogen is an exception. Deuterium is cheap. Gallon jugs of heavy water (D2O) were present in almost every lab i worked in as a grad student, and in all but one of them had never even been used. I shoulda pinched one....

However, as an isotope of hydrogen, the resulting compound would be considered the same as the normal version of it, so it would be covered by the phenethylamine act.
 
stom10 said:
I think his idea is to avoid analogue laws by deuterating the compound. I'm pretty sure that the law would see each compound equally.
Click to expand...

I've seen this very thing being done with Cathinones. I'm sure a google search would turn up more.
 
No the phenethylamine act here in the UK dose not cover substituting at the beta position. This is how all the cathinone analouge where legal until they passed the cathinone act last month. So I'm sure beta-deutro phenethlamines would not be covered like the beta ketones weren't.

Here is the cathinone act. My kemistry isnt brillant but I don't think it with catch beta-D's?

"Any compound (not being bupropion or a substance for the time being specified in paragraph 2.2) structurally derived from 2-amino-1-phenyl-1-propanone by modification in any of the following ways, that is to say,
(i) by substitution in the phenyl ring to any extent with alkyl, alkoxy, alkylenedioxy, haloalkyl or halide substituents, whether or not further substituted in the phenyl ring by one or more other univalent substituents;

(ii) by substitution at the 3-position with an alkyl substituent;

(iii) by substitution at the nitrogen atom with alkyl or dialkyl groups, or by inclusion of the nitrogen atom in a cyclic structure."

Can someone chime in on this?
 
ingo_1978 said:
No the phenethylamine act here in the UK dose not cover substituting at the beta position.
Click to expand...

It wouldn't be a cathinone if you deuteriate the beta carbon. You'd have something like ephedrine.
 
Do you think beta,betadideuteroamphetamine is possible, if so do you think it would dimish it's effects like cathinone compared to amphetamine?
 
^A Wolff-Kischner on propiophenone, using D2NND2 instead of hydrazine would give 1,1-dideuterium-1-phenylpropane. You'd need to prepare the D2NND2.

Isn't some deuterium present in everything anyway?

nb: This ain't an intermediate step in the preparation of amp, just an illustration of selective deuteration.
 
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In the UK, we have no analog act as such, merely some wideranging clauses in the misuse of drugs act.

The interesting thing I have noted is in said act, in banning the good doctor Shulgin's works, they banned specifically some of his deuterated amphetamines and phenethylamines.

It is of course the case that anything not specifically listed is permitted, so, question is..if its deuterated is the precedent set?
 
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