Beta-Blockers & drug interactions

[Crankinit]

I've recently been put on a low dose of beta blockers (10mg propranolol daily) for anxiety, and I'm wondering what potential interactions it could have with other drugs.

In particular, meth, MDMA, 4-mar and 2-cb. I've read mixed reports on the safety of combining beta blockers with stimulants, some sources say that there's a dangerous interaction, others say that it actually reduces the strain stimulants put on the cardiovascular system. I've got no idea at all about psychadelics, although I would assume whatever is true for stimulants would also be true for them, since they have a mild stimulant effect.

Any input from someone more knowledgeable than I would be appreciated :D

 

[dildonian jr.]

Drug Interaction
Acetohexamide- The beta-blocker decreases the symptoms of hypoglycemia
Aminophylline- Antagonism of action and increased effect of theophylline
Amobarbital- The barbiturate decreases the effect of metabolized beta-blocker
Aprobarbital-- The barbiturate decreases the effect of metabolized beta-blocker
Butabarbital- The barbiturate decreases the effect of metabolized beta-blocker
Butalbital- The barbiturate decreases the effect of metabolized beta-blocker
Butethal- The barbiturate decreases the effect of metabolized beta-blocker
Chlorpromazine- Increased effect of both drugs
Chlorpropamide- The beta-blocker decreases the symptoms of hypoglycemia
Cimetidine- Cimetidine increases the effect of the beta-blocker
Citalopram- The SSRI increases the effect of the beta-blocker
Clonidine- Increased hypertension when clonidine stopped
Dihydroergotamine- Ischemia with risk of gangrene
Dihydroergotoxine- Ischemia with risk of gangrene
Dihydroquinidine barbiturate- The barbiturate decreases the effect of metabolized beta-blocker
Diltiazem- Increased risk of bradycardia
Disopyramide- The beta-blocker increases toxicity of disopyramide
Dyphylline- Antagonism of action and increased effect of theophylline
Epinephrine- Hypertension, then bradycardia
Ergonovine- Ischemia with risk of gangrene
Ergotamine- Ischemia with risk of gangrene
Escitalopram- The SSRI increases the effect of the beta-blocker
Fenoterol- Antagonism
Fluoxetine- The SSRI increases the effect of the beta-blocker
Formoterol- Antagonism
Glibenclamide- The beta-blocker decreases the symptoms of hypoglycemia
Gliclazide- The beta-blocker decreases the symptoms of hypoglycemia
Glipizide- The beta-blocker decreases the symptoms of hypoglycemia
Glisoxepide- The beta-blocker decreases the symptoms of hypoglycemia
Glycodiazine- The beta-blocker decreases the symptoms of hypoglycemia
Haloperidol- Increased effect of both drugs
Heptabarbital- The barbiturate decreases the effect of metabolized beta-blocker
Hexobarbital- The barbiturate decreases the effect of metabolized beta-blocker
Hydralazine- Increased effect of both drugs
Ibuprofen -Risk of inhibition of renal prostaglandins
Indomethacin- Risk of inhibition of renal prostaglandins
Insulin -The beta-blocker decreases the symptoms of hypoglycemia
Isoproterenol- Antagonism
Lidocaine -The beta-blocker increases the effect and toxicity of lidocaine
Maprotiline- Propranolol increases the serum levels of cisapride
Mesoridazine- Increased risk of cardiotoxicity and arrhythmias
Methohexital- The barbiturate decreases the effect of metabolized beta-blocker
Methyldopa- Possible hypertensive crisis
Methylphenobarbital- The barbiturate decreases the effect of metabolized beta-blocker
Methysergide- Ischemia with risk of gangrene
Orciprenaline- Antagonism
Oxtriphylline- Antagonism of action and increased effect of theophylline
Paroxetine- The SSRI increases the effect of the beta-blocker
Pentobarbital- The barbiturate decreases the effect of metabolized beta-blocker
Phenobarbital- The barbiturate decreases the effect of metabolized beta-blocker
Pirbuterol -Antagonism
Piroxicam -Risk of inhibition of renal prostaglandins
Prazosin -Risk of hypotension at the beginning of therapy
Primidone -The barbiturate decreases the effect of metabolized beta-blocker
Procaterol- Antagonism
Propafenone- Propafenone increases the effect of the beta-blocker
Quinidine barbiturate- The barbiturate decreases the effect of metabolized beta-blocker
Repaglinide- The beta-blocker decreases the symptoms of hypoglycemia
Rifampin -Rifampin decreases the effect of the metabolized beta-blocker
Rizatriptan- Propranolol increases the effect and toxicity of rizatriptan
Salbutamol- Antagonism
Salmeterol- Antagonism
Secobarbital- The barbiturate decreases the effect of metabolized beta-blocker
Sertraline- The SSRI increases the effect of the beta-blocker
Talbutal- The barbiturate decreases the effect of metabolized beta-blocker
Terbutaline- Antagonism
Theophylline- Antagonism of action and increased effect of theophylline
Thioridazine- Increased risk of cardiotoxicity and arrhythmias
Tolazamide- The beta-blocker decreases the symptoms of hypoglycemia
Tolbutamide- The beta-blocker decreases the symptoms of hypoglycemia
Verapamil- Increased effect of both drugs



brought to you by:
http://www.drugbank.ca/drugs/DB00571

 

[Crankinit]

Thanks for the link, but that doesn't really address recreational drugs

 

[capRx]

^the thing with contraindications list is they don't tell you shit. You have to know how to read them. I personally have looked into being prescribed a beta-blocker with amphetmines, and it isnt a good idea.

Your body has a way of balancing itself out with with blood pressure and heart rate. When your take beta blockers, you just block the beta adrenergic receptors. The amphetamines are still going to act on the alpha adrenergic receptor which will constrict your blood vessels and lead to hypertension and lower cardiac output. Thats where you can run into problems..

I personally wouldn't recommend it, but I have seen people do it.. If you are going to do it, use it for the comedown and not concurrently. My recommendation would be to stick with an entirely different mechanism to counteract the amphetamine such as GABA (ex. benzos)

Same goes for meth and MDMA.

2c-b should be fine. i don't see a problem there.

and i don't know enough about the pharmacology of 4-mar to comment on that..