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Miscellaneous Best & Worst Drug Crosses You've Ever Done

Shinji Ikari said:
Mescaline and LSD ❤️
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Yes. A very spooky combo when I did them together at night. My second time was better though. It was a powerful ego-killing dose of acid taken at the start of the night at an outdoor psytrance event followed by a dose of mescaline tea swallowed at the crack of dawn. As the sun rose, the mescaline kicked in with a tremendous warmth and euphoria, like the sun was also rising inside my body, filling it with warmth and happiness. Dancing to music, I felt like I had levitated and was floating and drifting in the breeze. It was the closest thing I can imagine to being in heaven and among the most uplifting and euphoric moments of my life.
 
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Worst... Wellbutrin, Zoloft, Diphenhydramine together with weed. It was an awful feeling. Best... LSD, Weed and Beer.
 
mdmaxanaxketamine said:
I did around 5g of capsules shrooms that were definitely under dosed so it only felt like 3.5g-ish. I did a small bump of K to ease the come up anxiety, and then cruised for a couple hours off the shrooms, then binged on at least a half g of ket til I fell asleep by doing half a point lines every 45 minutes to an hour. Was fucking amazing. Just did LSD and a bunch of ket yesterday and will have to say LSD + Ket mixes a lot better than Ket + shrooms
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I had 27 incredibly weak tabs, and my boyfriend and I decided to split them. Thirty minutes after we decided that it wasn't cutting it so we each dropped 2 tabs of 25C-NBOMe, and half an hour after that started doing hourly 30-45mg lines of "CanKet", 2'-Fluoro-2-Oxo-PCE. It was one of the best trips either of us can remember, holding up only to a 3-MeO-PCP, MDA/MDMA and 2C-B cross that occurred last winter.

This experience we just had was one of those trips so intense and ego dissolving that it's completely beyond articulation, +++/++++.

Ketamine (and its close analogs) and acid truly do feel like they're meant for each other, similarly to how I feel about mescaline and MDMA as well. Honestly, I prefer allylescaline over mescaline and CanKet over ketamine, if given the choice.
foodcrisis said:
curious if you've tried psychedelics and enjoyed them at all with out weed? it sounds like you just don't like shrooms in general? and also how is your relationship with weed by itself? do you normally think it's alright, or is it like hit or miss? i'm just wondering because i always say if a person really loves weed and doesn't like the body load of shrooms that a person might want to try smoking... i've heard people actually disagree with me, but it's not common. i'm just trying to get a general opinion...
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Just to pitch in my observations on weed + psychedelics, for most people at least, it's nightmare fuel. I know many people who can take very high doses of psychedelics (though often not mushrooms specifically) but cannot tolerate even a small joint or a 25mg edible on its own without distress. That distress becomes amplified in the presence of a psychedelic or other dissociative. These people also consistently do not enjoy salvia at "breakthrough" doses.
Shinji Ikari said:
Mescaline and LSD ❤️

4-ho-met is fun in its own but ruins everything you combine it with ime.
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How does metocin ruin things you combine it with? Just curious because I've had mushrooms and acid be uniquely useless in the sense that my short term memory became probably less than a second, I could barely even figure out that I existed but in a way that felt like a computer running out of RAM. Miprocin though mixes well with an extremely long list of psychedelics in my experience. Not as well as mescaline and its analogs though.
Innerpeace said:
Some of worst trips have been on sub-4 typtamines. I think a lot of it was walking around house with eyes open. Walking in nature it wasnt that bad, did a five hour hike with brother a few times on 4-ho-mipt...second time mixed with 5mapb...that was chill.. If close eyes on sub-4's and lsd, most of the time, that it helps focus on internal stuff and helps resolve itself. When eyes open this doesnt seem top happen, so recommend music and even certain types of music that have been studied. Andrew Huberman has a podcast on shrooms and what music to listen to with them thats been "studied" I find it might not be exact, and can tailor it to your own enviroment, but it does help and good blueprint. Lsd have all been good, despite being in the same setting a few times.

When in doubt about mixing two, even with cannabis, best not too. If so, do at own risk bc have heard many times not to mix cannabis with shrooms, lsd. Ive mixed cannabis thc with mdma ,on the comeup, many, many times, and found that little to no thc, high cbd cannabis can ease the come up, cause greater relaxation, transitioning into a smooth roll.
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Your comments here about music shaping and impacting experiences is something that I hope to see more of as psychedelic therapy grows more of a cultural context here in the west. I've yet to try DiPT or 5-MeO-DiPT, but sinicuichi (especially in combination with LSD) led to auditory hallucinations of hearing the sounds of my busy city neighborhood proceed to play itself backwards and kind of fragment out similarly to a fractal with changes in timbre, pitch, and splitting apart as to create harmonies of separate sonic textures. It changed how I produce glitch music for sure. I also used to DJ, so the concept of building a set for a certain vibe is something I've been doing for a while, and when I guide friends' trips I'm always thinking about how badly I wish there was more study into how this could best be done. I guess an EEG helmet and FL Studio, or just the mixing of live ambient loops perhaps, could be fun.

My second trip was just my friends and I after eating a mushroom chocolate bar, playing with a semi-modular synthesizer in the neighborhood I grew up in. Patching in new, unexpected, and exciting sounds with our hands was really fascinating compared to more digital approaches to interacting with sound.
 
Esperighanto said:
How does metocin ruin things you combine it with? Just curious because I've had mushrooms and acid be uniquely useless in the sense that my short term memory became probably less than a second, I could barely even figure out that I existed but in a way that felt like a computer running out of RAM. Miprocin though mixes well with an extremely long list of psychedelics in my experience. Not as well as mescaline and its analogs though
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Zero synergy it just overpowers whatever psychedelic I stack it on top of while adding a horrible body load. I've tried taking it after 2cb, LSD, and LSD+mescaline on multiple occasions and all it's done is kill the headspace, pile in some pseudo-psilocybin visuals and deprive me of the afterglow I would usually experience after taking any of those aforementioned psychedelics. Every single time I've tried it in a combo I've regretted it and just found myself bored and uncomfortable waiting for it to wear off.

And yet some people report glowing experiences. Weird.

I didn't enjoy lsd+shrooms either. Similar to what you said, my working memory took such a hit that I wasn't able to make much sense of my thoughts or do anything useful with them, but that at least might have been deep if I could think clearly.
 
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Shinji Ikari said:
Zero synergy it just overpowers whatever psychedelic I stack it on top of while adding a horrible body load. I've tried taking it after 2cb, LSD, and LSD+mescaline on multiple occasions and all it's done is kill the headspace, pile in some pseudo-psilocybin visuals and deprive me of the afterglow I would usually experience after taking any of those aforementioned psychedelics. Every single time I've tried it in a combo I've regretted it and just found myself bored and uncomfortable waiting for it to wear off.

And yet some people report glowing experiences. Weird.

I didn't enjoy lsd+shrooms either. Similar to what you said, my working memory took such a hit that I wasn't able to make much sense of my thoughts or do anything useful with them, but that at least might have been deep if I could think clearly.
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It could be deep if guided correctly I'm sure, but I didn't have a guide, just a sober tripsitter. He's a best friend of mine who was pretty worried, and kept repacking and feeding me bowls of flower bc it eventually got me back to normal. I'm one of the fortunate people where cannabis has essentially always been positively impactful on any experience.


Have you ever used miprocin? I've yet to try ethocybin just because I so constantly have a psychedelic tolerance, but I need to soon, to compare it to mushrooms, psilacetin, and miprocin, especially in the context of mixes. Miprocin and DOM is a favorite mix of mine, as are miprocin with 2C-B, and miprocin with LSD. I'm sitting on 4g of Jack Frost fungi I intend on mixing with 10mg of DOM sometime soon, I'm looking forward to how it goes.
 
Esperighanto said:
It could be deep if guided correctly I'm sure, but I didn't have a guide, just a sober tripsitter. He's a best friend of mine who was pretty worried, and kept repacking and feeding me bowls of flower bc it eventually got me back to normal. I'm one of the fortunate people where cannabis has essentially always been positively impactful on any experience.


Have you ever used miprocin? I've yet to try ethocybin just because I so constantly have a psychedelic tolerance, but I need to soon, to compare it to mushrooms, psilacetin, and miprocin, especially in the context of mixes. Miprocin and DOM is a favorite mix of mine, as are miprocin with 2C-B, and miprocin with LSD. I'm sitting on 4g of Jack Frost fungi I intend on mixing with 10mg of DOM sometime soon, I'm looking forward to how it goes.
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Interesting that the cannabis helped level you out, I think most people find that LSD become much less clearheaded when cannabis is thrown into the mix. I like mixing them (I'm usually stoned in my free time anyway) but it caught me off guard the first time I took acid how much loopier my thoughts got after I smoking a joint when I'd been so lucid just a few minutes before.

Haven't tried miprocin or any of the 4-subs besides 4-ho-met and 4-aco-dmt because I cant source them. I'm always keeping an eye out and i'll snap some up if I ever see a domestic vendor stocking it. DOM is also on my list to try, fortunately I have seen that one floating around the DNMs so I'll probably try it sooner rather than later.

I mixed 15mg of 2cb with 8mg of 4-aco-dmt last night and was surprised how well they synergized. The headspace was close to what I'd get from a 15mg dose of 4-aco but less pushy. Might try it again with 25mg of 2cb and 15mg of 4-aco-dmt and see how things scale.

Have you tried mixing mescaline with anything?
 
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Shinji Ikari said:
Interesting that the cannabis helped level you out, I think most people find that LSD become much less clearheaded when cannabis is thrown into the mix. I like mixing them (I'm usually stoned in my free time anyway) but it caught me off guard the first time I took acid how much loopier my thoughts got after I smoking a joint when I'd been so lucid just a few minutes before.

Haven't tried miprocin or any of the 4-subs besides 4-ho-met and 4-aco-dmt because I cant source them. I'm always keeping an eye out and i'll snap some up if I ever see a domestic vendor stocking it. DOM is also on my list to try, fortunately I have seen that one floating around the DNMs so I'll probably try it sooner rather than later.

I mixed 15mg of 2cb with 8mg of 4-aco-dmt last night and was surprised how well they synergized. The headspace was close to what I'd get from a 15mg dose of 4-aco but less pushy. Might try it again with 25mg of 2cb and 15mg of 4-aco-dmt and see how things scale.

Have you tried mixing mescaline with anything?
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I've never mixed mescaline with anything, but I've mixed allylescaline with LSD, 2C-B, 3-HO-PCP, CanKet, NEP, 1,4-BDO, THC-O tincture, some 3-MeO-PCP dippers, and of course a comical amount of cannabis in different forms. It mixed beautifully with all of those but the BDO kind of dulled it too much and the best mixes were NEP, 3-HO-PCP, LSD and CanKet.

Allylescaline with 3-HO-PCP and LSD at the same time is one of the best mixes I've ever done in my entire life, I'm still more present as a result of that night.

CanKet, NEP and allylescaline was an interesting mix, one that I found unbelievably powerful for creativity even compared to allylescaline on its own or allylescaline alongside 2C-B.

Allylescaline, 3-MeO-PCP dippers, 2C-B and a little bit of a heavy dose of oral THC-O also put me in a very creative headspace but it was cloudier and harder to actually play instruments and compose midi in that state, compared to the CanKet/NEP/AL mix.
 
Worst : alcohol and Roihpnol ( a benzo that hopefully has been banned in Europe already, here is part of the toolkit of your average rapist
2nd worst : alcohol oxys & blow, opi and alcohol don t mix
BEST : oxys and cocaine, with a lil bit of Conazepam here and there
 
I've had a million really wild combos, but def up there was 5-meo-mipt with DMT right at the peak. fucking crazy.

Also enjoyed 2C-E and 2C-B that was like hyperspace for 6 hours. Def had some vasoconstriction though.

I don't know about my worst combo. 50mg of 2C-T7 and 20mg of 2C-T2 was pretty terrible.
 
Esperighanto said:
I've never mixed mescaline with anything, but I've mixed allylescaline with LSD, 2C-B, 3-HO-PCP, CanKet, NEP, 1,4-BDO, THC-O tincture, some 3-MeO-PCP dippers, and of course a comical amount of cannabis in different forms. It mixed beautifully with all of those but the BDO kind of dulled it too much and the best mixes were NEP, 3-HO-PCP, LSD and CanKet.

Allylescaline with 3-HO-PCP and LSD at the same time is one of the best mixes I've ever done in my entire life, I'm still more present as a result of that night.

CanKet, NEP and allylescaline was an interesting mix, one that I found unbelievably powerful for creativity even compared to allylescaline on its own or allylescaline alongside 2C-B.

Allylescaline, 3-MeO-PCP dippers, 2C-B and a little bit of a heavy dose of oral THC-O also put me in a very creative headspace but it was cloudier and harder to actually play instruments and compose midi in that state, compared to the CanKet/NEP/AL mix.
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Quit it with the endless list of designer drugs I can't access already! I'm grateful that I have access to synthetic mescaline at all but whenever I hear these analogues mentioned I can't help licking my lips. Same with the PCP family, the only dissos I've tried are NOS and ketamine and for reasons I really can't understand there doesn't seem to be a resale market in the UK.

I digress.

You really must try LSD and mescaline though it's sublime in every way. Absolute magic. You're so so very high, but lucid at the same time. Even on 750G/500ug I could still function and go out and explore the city (using my phone or reading a map was nearly impossible I'll admit).
skipjames said:
Worst : alcohol and Roihpnol ( a benzo that hopefully has been banned in Europe already, here is part of the toolkit of your average rapist
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I forgot roofies ever even existed. It kind of feels like GHB ended up taking it's place in the public consciousness.
 
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Shinji Ikari said:
Zero synergy it just overpowers whatever psychedelic I stack it on top of while adding a horrible body load. I've tried taking it after 2cb, LSD, and LSD+mescaline on multiple occasions and all it's done is kill the headspace, pile in some pseudo-psilocybin visuals and deprive me of the afterglow I would usually experience after taking any of those aforementioned psychedelics. Every single time I've tried it in a combo I've regretted it and just found myself bored and uncomfortable waiting for it to wear off.

And yet some people report glowing experiences. Weird.

I didn't enjoy lsd+shrooms either. Similar to what you said, my working memory took such a hit that I wasn't able to make much sense of my thoughts or do anything useful with them, but that at least might have been deep if I could think clearly.
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You're missing out on one of the better psychedelic combos of the RC era (imho) - 2cb + 4-aco/ho-MET - dose 1:1.

For the 'traditional' (as in my traditional way) of dosing it - pour your measured 2cb and 4-aco-met into a shot glass, and then fill the glass with equal parts tequila, ginger beer, and ginger kombucha.

You have now created *Ghost Potion* - a very recreational but valuably emotional and social psychedelic experience. Great for taking with friends and bonding while worrying little about altered cognitive status. You can redose pretty well, and ultimately it lasts only about 4-6 hours after your last dose.

Effects are highly visual - both 4subMET visuals which then synergize with the weird visuals made by 2cb. SInce they're so different, they're not overpowered by the 4-sub-met. Effects are euphoric/energizing, milldly entactogenic and empathogenic. Effects can be great for processing difficult emotions while in a less serious headspace than straight 2cb. I also find the body trip more pleasaurable than 2cb alone. Finally, there's very little, if any, cognitive change. It's a very clear headed trip.
 
Combos are my specialty. There are a couple that really stand out though.

First and foremost is the Trifecta Trip, hitting all 3 major hallucinogen styles , psychedelic, dissociative and deliriant at once (kappa opioids aside). In my case it was DXM + 4-AcO-MET + DPH. Those were some of the most amazing hallucinations I have ever had (I can provide a trip report for anyone interested). It requires a special recipe though. You can't take them all at once or it just blows up and leads to a blackout. There's a process and timing that makes the magic possible.

Another one is LSD + MDMA + K, then blowing a line of Ketamollicaine (Ketamine + MDMA + Cocaine) at the peak was truly special. An absolute explosion of pink and sweat and love.

Mixing 5-MeO-DMT and Salvia into one bowl and smoking that while on Ketamine has become a little ritual for me when I need a healing.

Then of course there's the classic DMT + Nitrous (also best experienced while already on either LSD, Ketamine, or both).

I had an absolutely mind bending experience getting to DXM sigma, shooting IV 4-AcO-MET and then smoking Salvia (I have a TR for this one too).

One of the most powerful trips I've ever had was Memantine + DXM + 1200µg ETH-LAD and saw the universe in 6 dimensions (another TR I have saved).

I accessed the Information Superhighway combining DXM with 100mg 4-AcO-DMT (plugged).

The list goes on. There are so many secret recipes and combos that have special properties if you hit them just right. I can't even think of them all of the top of my head, although I have notes on every combo I've ever tried. These are just the ones that spring to mind as truly special.
 
My favorite by far would be LSD + Meth + Sex There is lierally nothing like it, being able to have long intense orgasms consecutively without having to stop in between to "recoup" is out of this world , plus meth makes me so horny and you can literally last as long as you want. It's the only time that I consider the meth high to not feel "dirty".

Worst combo would be any psychedelic mixed with any amount of THC I can take psyches with any other drugs, stims, opiates, dissociates, etc. but the second I take a puff I lose my mind. Instant psychosis, it makes me anxious, gives me anxiety, panic attacks. Some of the worst paranoia ever and even delusions. Even just weed alone fucks with me I have to use small amounts and it has to be at night. I started to get these effects when I got older (21-23) when I was younger I could smoke 24/7 as much as I wanted but now, I take too many hits and I think my heart is going to just stop beating or I'm going to stroke out.
 
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Pretty wild combos that some of you describe. :stoned:

My favorite combo taking alone is LSD + vaping cannabis. I take the LSD in the morning and after peaking the cannabis session starts. With sativa the whole experience lasts for more than 16 hours ... it goes on and on and on. I love it.

Best combo for partying is MDMA + Ketamine. Feels like the room becomes liquid and is made of pure euphoria. Absolutely fascinating.
 
nepalnt21 said:
worst (and almost best) is dxm, acid, and datura (i dunno why i'm r-slurred)... the datura definitely puts me in a stupid and crazy mindset where i'm likely to make bad decisions that end up affecting other ppl negatively. in small amounts, it can add a nice woozily... uh... zhenna say kwa quality but it's too risky.
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You had a true Schizopherinc or psychotic moment because you had SNDRI + NMDA antagonism + M1 antagonism. The trip(even If you can call It one) Is your brain freaking out It can OC It self 200x without catching fire. Also their the rewire phase where If you had booze dopamine would keep you awake instead of NMDA.
 
I can't think of any combos I've done that are specifically terrible, I've never had a bad trip/drug experience outside of single doses of anticholinergics in combination with nothing else, but trying to list some of the best ones:
  • 3-MeO-PCP, MDA and 2C-B.
  • 25C-NBOMe, MDA and a xanny I got off the street that lasted maybe 3-5 hours, so I'm assuming it was legit and not bromazolam but I can't be positive.
  • 3-HO-PCP, Allylescaline, and 2C-B.
  • Harmaline, tetrahydroharmine, and DMT/trace amounts of 5-MeO-DMT due to the plant matter I was extracting from.
  • Miprocin, 2C-B, DOM and dippers containing 3-MeO-PCP.
  • Ketamine, LSD and 2C-B.
  • 25C-NBOMe (as well as a separate variant of this mix with 25I-NBOMe) alongside CanKet, which is sometimes referred to as 2-FXE or 2F-O-PCE.
Keep in mind that virtually every one of these experiences are also involved pretty massive quantities of cannabis.
 
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