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Opioids Best Way to Take Oxycodone.......

"Just fuckin eat it".

Why? In that case, just fucking eat heroin, at high doses it's BA is actually about the same... But seriously, to dispell the many myths of oxycodone:

First off, IV oxycodone is 1.5-2x as potent as oral oxycodone(and it tends to be 2x more often than 1.5x), and, the half-life of IV oxycodone is EXACTLY THE SAME AS THE ORAL HALF-LIFE. So IV oxycodone is 1.5-2x as potent as oral, and lasts just as long. So they're is literally no advantage to oral oxycodone, when compared to IV(or even IM). Of course injecting is bad and blah blah, but if your already injecting H and dillies, IV oxy is literally superior in every way

Secondly(and this is related to the first) the oral BA of oxycodone is not "very high" as everyone claims. In reality, the oral BA is highly variable, ranging anywhere from 35-90%. The mean is somewhere between 50-70%, though it appears to be much closer to 50 than 70%.

And finally, oral is not better than intranasal. Despite what many have claimed, the oral and nasal BA's are about the same, both around 50%. However, intranasal hits much faster, with a tman of 10-20min, vs oral, which had a tmax of around 90 minutes.

So all in all, oral has no benefits, aside from simplicity. IV is much stronger, and with an identical half-life; intranasal is about the same, at worst, the BA might average a tiny bit lower, but no one would notice the slight difference, and it is compensated by the MUCH FASTEE onset. So technically, IV is the best,(though not exactly recommended!) with intranasal and oral being tied, although I think most would agree intranasal is superior.(Not me, I don't snort drugs :) )


Edit: Rybee I saw your other post, and thanks. And let me clarify I'm not being rude, it's just that they're us a lot of misinformation about oxycodone,(among other things) and I am trying to clear it up!!!

Finally someone else who gets it :D Back when I was shooting oxys, every second time I'd post on the subject I'd get half a dozen ''just eat them man, they have 90% oral BA, shooting oxy is useless, etc etc etc'' responses. Meanwhile I'd gone from eating 200mg to shooting 80mg, with a negligible decrease in duration.

Anyway, I'm not advocating people start IVing who don't already do so, just glad to see someone else who understands that IV oxy is significantly more efficient than oral :p
 
I have an extremely high tolerance to Opiates. I wondered if I would feel better taking Methadone rather than what I take now. I take MORPHINE Instant release of 330mg which is 11 3omg pills. I want to make sure I cop the same high as well as relief of my pain. Our great U.S.Of A. at the Veterans Admin Hospital has me taking that much and I'm not even dying from cancer or anything like that. I just wonder if it would leave me with more energy to do things. I want to get out and live . I miss having the Love of a nice lady . No one can tell when I take my drug. I also take 4mg of Clonazepam. NO I'm not going to tell you the name of my doctor. I have chronic pain and I am living with it.But I don't get out much and I truly miss something people take for grated. I'm about 60 and people tell me I look 45 and I still have it ion me to Love. GOD KNOWS HOW MUCH I MISS LOVING A WOMAN AND FEELING LOVED BACK. I just want to know if Methadone could do the same thing as all that Morphine dose and leave me with enough energy to do things with another and to be able ton Love before I end up dying. I'm not dying now. Men in my family don'
t live long and I just want to fall in real love just one last time before I do waste what time I have left on this good earth. THIS IS NOT A JOKE AND I AM TELLING YOU THE TRUTH HOPING FOR A NICE ANSWER> I am a very lonely man and I just don't know if one thing would work better than another. I am mentally and physically able to Love a Woman very Much For many years to come. Can anyone giver me a good answer to this. I'ts the only thing I feel so empty over and Hope Someone can help. I got to find her and that has been real hard too. Lazarusnumber2 PLEASE. THIS IS NO JOKE TO ME> I THINK WE ALL STILL NEED TO FEEL LOVED AND WANT TO LOVE BACK
 
Finally someone else who gets it :D Back when I was shooting oxys, every second time I'd post on the subject I'd get half a dozen ''just eat them man, they have 90% oral BA, shooting oxy is useless, etc etc etc'' responses. Meanwhile I'd gone from eating 200mg to shooting 80mg, with a negligible decrease in duration.

Anyway, I'm not advocating people start IVing who don't already do so, just glad to see someone else who understands that IV oxy is significantly more efficient than oral :p

Yeah, it's asanine for so someone to tell me that my 90mg-120mg IV oxy or whatever isn't better than swallowing. I mean, all you have to do is a little research.

More importantly, anyone who had actually shot it, will laugh at the idea that oral is 90% as effective?
But yeah, it's not worth the needle if you haven't alread started, much less for oxycodone.

(I feel bad for the snorters too. Though; they've been told they are silly, but really, oral/intranasal is the same, so... More power to them!!!

Ps: the half-life of IV oxy and oral oxy is exactly the same(so says every study known to man) so "negligible decrease" is about right... Really only the near-instantaneous Tmax(5vs90min) would make it appear shorter...)
 
Lazarusnumber2 - I feel for you, I really do. If I were your age and single I'd definitely shoot you a PM :) but alas I'm 34 and happily married, so not a candidate for you. But I agree totally on wanting your life back. I have been in chronic pain for almost a year now and I thought I would be better by now but things are just getting worse with my physical condition. I can't go out, have a life, I can barely take care of my children (I have three little ones, and I feel HORRIBLE about leaving so much of the parenting to my husband but I'm unable to even get out of bed some days.) I want my life back. I want my happiness back. I want for ONE FUCKING MINUTE not to be in pain. Because I always am, no matter what I take or what I do. Even in my sleep I'm in pain - I have DREAMS that center around it, when I'm able to sleep, and sometimes I just can't. I wake in the middle of the night with shooting pains in my back and aches and pains everywhere else and I can only cry about it because there's nothing I can do. I was uninsured for a while but now that I've got my insurance back I'm trying to do something about it. My in-laws (with whom I live) see me as nothing but a junkie who wants pain pills for fun, when nothing could be farther from the truth. In fact, I go to a pain clinic where they don't prescribe opiates, just so that they don't think I'm a junkie. Meanwhile I've been buying opiates online, poppy and sometimes pills, to try to pull myself together enough so that SOMETIMES I can come down and have dinner with the family (mostly I don't eat; I've lost a ton of weight and still losing, I look almost anorexic by now) or I can take care of my baby son or drive myself to appointments since no one will drive me. They're all, I guess, suffering from "compassion fatigue" which is what happens when someone is sick as long as I have been...eventually they just say "the hell with it" and leave me alone. And don't bother to wake me up for things or make sure I eat or anything. It feels like no one cares anymore.

I know what you're feeling, I really do. I just wanted to reach out and tell you you're not alone. I, too, feel unloved...unloved by my family, who can't understand why I'm not better. I don't understand it either. Only a doctor can explain it and I hope we figure it out soon so I know if I have to be on a maintainance med for the rest of my life or if this will go away.
 
id disagree wholeheartedly. i found plugging opiates to give me a shitty high (no pun intended), and its not worth all the extra "steps", if you will.

just my opinion, could be horribly wrong according to your theory

Extra steps? If you mean the (approximately guessed) 2 extra minutes to open up the capped Pill(s), pour out the HcL and add some water before pulling the solution into a syringe and insert, then i for myself think those 2 minutes are worth it if you want a (subjectively felt) quicker onset and stronger rush/intensity; in short: more bounce for the ounce!
 
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The problem with this thread IMO is that everyone is arguing the "best" way to take oxycodone, but the truth is that "best" can vary from person to person depending on their ultimate objective.

I think it is obvious, like many has said, that the IV rout with provide the most efficient effects. Furthermore, this also avoids the first pass through the liver, and has that benefit as well. Although, most know the risks associated with going down this path...

However, the true tone of the OP's initial post really seems like he is asking how to best potentiate oxycodone via the nasal, rectal, or oral ROAs - despite the name of the thread. So first we need to clarify what he really means by "best" (longest duration, most efficient, best high, safest, etc etc). I think oral / recal probably are the safest ROAs with the least possible adverse side effects / risks. If he is limited in the ROA he is willing to do, then perhaps we need to switch the discussion to how to potentiate it given is selected ROAs.

Lazerousnumber2 - I guess I don't fully understand why your medication is preventing you from finding a woman and falling in love? If it is because of how out of it it makes you feel, then you have to ask yourself if you really do want to maintain the pain relief and the "high", as the high is going to inevitably effect your energy and ability to act sober. Wanting to maintain your high and be able to act perfectly normal may be impossible, and you may have to choose...Also, yes, methadone could probably help in some regards, but I think we would need a little more information regarding your specific objectives. Personally, I would recommend trying to find someone online. Not only is it more efficient, but you will be able to establish a bond prior to having to meet in person and disclosing your medication and or energy level. Love can overcome a lot of things once established.
 
I have an extremely high tolerance to Opiates. I wondered if I would feel better taking Methadone rather than what I take now. I take MORPHINE Instant release of 330mg which is 11 3omg pills. I want to make sure I cop the same high as well as relief of my pain. Our great U.S.Of A. at the Veterans Admin Hospital has me taking that much and I'm not even dying from cancer or anything like that. I just wonder if it would leave me with more energy to do things. I want to get out and live . I miss having the Love of a nice lady . No one can tell when I take my drug. I also take 4mg of Clonazepam. NO I'm not going to tell you the name of my doctor. I have chronic pain and I am living with it.But I don't get out much and I truly miss something people take for grated. I'm about 60 and people tell me I look 45 and I still have it ion me to Love. GOD KNOWS HOW MUCH I MISS LOVING A WOMAN AND FEELING LOVED BACK. I just want to know if Methadone could do the same thing as all that Morphine dose and leave me with enough energy to do things with another and to be able ton Love before I end up dying. I'm not dying now. Men in my family don'
t live long and I just want to fall in real love just one last time before I do waste what time I have left on this good earth. THIS IS NOT A JOKE AND I AM TELLING YOU THE TRUTH HOPING FOR A NICE ANSWER> I am a very lonely man and I just don't know if one thing would work better than another. I am mentally and physically able to Love a Woman very Much For many years to come. Can anyone giver me a good answer to this. I'ts the only thing I feel so empty over and Hope Someone can help. I got to find her and that has been real hard too. Lazarusnumber2 PLEASE. THIS IS NO JOKE TO ME> I THINK WE ALL STILL NEED TO FEEL LOVED AND WANT TO LOVE BACK

Get off morphine and switch to oxy. I function very well and lead a normal life on it. But without it I am in fkin hell.
 
^ Because of what? Addiction or because you can't handle the Pain? And in the long run any Opioid will affect ones Life (especially things like sex-drive/libido) if the dosage is high enough, and 330mgs of Morphine is a lot - well at least that's what i'm thinking! The dose of Oxy needed for the same analgesic effects obviously will be somewhat lower as it's stronger, and still i don't think it'll be 'low enough' - but then the Intake/Consumption-Regimen (daily/as needed) also plays a Major Role in how much of an impact it has.
 
Yeah, it's asanine for so someone to tell me that my 90mg-120mg IV oxy or whatever isn't better than swallowing. I mean, all you have to do is a little research.

More importantly, anyone who had actually shot it, will laugh at the idea that oral is 90% as effective?
But yeah, it's not worth the needle if you haven't alread started, much less for oxycodone.

(I feel bad for the snorters too. Though; they've been told they are silly, but really, oral/intranasal is the same, so... More power to them!!!

Ps: the half-life of IV oxy and oral oxy is exactly the same(so says every study known to man) so "negligible decrease" is about right... Really only the near-instantaneous Tmax(5vs90min) would make it appear shorter...)

Let's see this research, site some sources to back up your rather outlandish claims like that heroin is as BA as oxycodone orally, sounds like a whole lotta bullshit padded with basic pharmacokinetic terms. Intravenous oxycodone in no way ever stood out to me as being any better than an equal dose taken orally or rectally even both worked a helluva lot better than oxycodone. even IV'd, it does not go directly to your brain, it goes to your heart and then gets pumped all over your body, it's not like for example how methamphetamine can so easily reach the BBB and diffuse across in WAY less time than IV'd when one inhales vaporized methamphetamine through their nostrils it hits instantly and I know methamphetamine is absolutely incomparable to oxycodone because besides the whole not an opioid and total different class of drug aspect, to be blunt, it actually packs a punch that can make your knees give out the rush is so intense. Oxycodone IV which I've done extensively, was always:

1) Disappointing
2) in hindsight, more to satisfy a needle fetish than to get the type of instantaneous and significant change in mindset and physical perception that normally the IV route is saved for.
3) A waste of needles, isopropyl/pre-and-post-admin sterilization and antibiotic compounds, micron filters, and just.... injections I shouldn't have put into my body.

I'm NOT saying, don't shoot up oxycodone cuz it's weak, im not saying the IV route is weak, it's as strong as whatever dose you'd normally take via the IMO vastly superior in longevity and intensity with only the smallest bit of patience via the oral and/or rectal routes of administration. And I'm NOT saying that because it's not worth shooting, that methamphetamine is. I don't condone the intravenous abuse of any drug, but seriously if you're going to be doing your body that harm, of all things to be injecting.... oxycodone is pretty pathetic in my experience and in no way justifies the risks.


How the hell is this thread still open, I wondered originally when stumbling in here. Of course, the age old debate about injecting oxycodone....... When will this topic die
rolleyes.gif
 
Sorry tri, im in here. It's aliveee!! I micron filter now ;) Rxd oxycodone and IV the whole script. On the way home from the pharmacy I will eat one pill but that it. For me personally, the effects are much LeSs intense orally administered. There is no traditional "rush" with oxy as all of you know but rather an intense instant onset that can be interpreted by some as a rush. Overall I'm in the crowd that says with the price of oxy nowadays, IV or bust.
 
For those who think oral oxy "doesn't work":

1. You need to defeat the time-release, or you'll just have a low serum-drug level for a really long time.
2. You need to adjust the dose upward from IV (even though the bioavailability is over 70 percent or so), since the drug is absorbed over the course of one to a few hours in your GI tract (oral dosing is nature's time-release ;)).

ebola
 
I've got 5mg roxys (no apap), and experimented with shooting them recently. I got some effect, but noticed that most of the binders wouldn't dissolve. So I'm assuming that the oxycodone is soluble while the binders are not. Is a micron filter the best way to try and separate all the water in the spoon from the left over binders?

I know it's likely futile, just curious at this point.
 
Let's see this research, site some sources to back up your rather outlandish claims like that heroin is as BA as oxycodone orally, sounds like a whole lotta bullshit padded with basic pharmacokinetic terms. Intravenous oxycodone in no way ever stood out to me as being any better than an equal dose taken orally or rectally even both worked a helluva lot better than oxycodone. even IV'd, it does not go directly to your brain, it goes to your heart and then gets pumped all over your body, it's not like for example how methamphetamine can so easily reach the BBB and diffuse across in WAY less time than IV'd when one inhales vaporized methamphetamine through their nostrils it hits instantly and I know methamphetamine is absolutely incomparable to oxycodone because besides the whole not an opioid and total different class of drug aspect, to be blunt, it actually packs a punch that can make your knees give out the rush is so intense. Oxycodone IV which I've done extensively, was always:

1) Disappointing
2) in hindsight, more to satisfy a needle fetish than to get the type of instantaneous and significant change in mindset and physical perception that normally the IV route is saved for.
3) A waste of needles, isopropyl/pre-and-post-admin sterilization and antibiotic compounds, micron filters, and just.... injections I shouldn't have put into my body.

I'm NOT saying, don't shoot up oxycodone cuz it's weak, im not saying the IV route is weak, it's as strong as whatever dose you'd normally take via the IMO vastly superior in longevity and intensity with only the smallest bit of patience via the oral and/or rectal routes of administration. And I'm NOT saying that because it's not worth shooting, that methamphetamine is. I don't condone the intravenous abuse of any drug, but seriously if you're going to be doing your body that harm, of all things to be injecting.... oxycodone is pretty pathetic in my experience and in no way justifies the risks.


How the hell is this thread still open, I wondered originally when stumbling in here. Of course, the age old debate about injecting oxycodone....... When will this topic die
rolleyes.gif

Are you joking? "Outlandish claims"? Seriously? I've posted refs in different threads, hell I'll post more. But what is outlandish about it? Oxy BA varies from 40-90%, oral H BA is dose dependent, and can range from as low as 20%, to 75% at high doses.

Remember, oral diamorphine is 1.5-2x as potent as oral morphine. Guess what? Oral oxycodone is 1.5-2x as potent as (chronic) oral morphine. That by extension makes oral H and oxy on par.(At least at high doses).

And I've already discussed in detail that rectal oxycodone is absorbed more slowly than oral, with a longer tmax, and lower cmax. The trade off is that it has a longer duration than either IV or PO.

If you didn't like IV oxycodone, that's your business. And injecting any pill carries risks, so it's really a good thing. But in my experience, anyone not liking IV oxycodone either has a very high tolerance, it didn't do enough. But I myself think oxycodone is overrated, I am just trying to get the FACTS out there.

As you well know, everyone is different, and everyone is entitled to do oxy(and all other drugs) they're own way.

I just don't understand your attitude, I explain everything I post and have no problem posting references l, which I have done many times. If you don't like IV oxycodone, fine, I mean really it's good you don't, but it doesn't make anything I say less true, and you certainly don't need to get an attitude, I'll happily discuss and back up any claim I make.

And I don't know what the meth thing is about. As for the "bbb", clearly the CNS penetration is the same regardless of route. But oxycodone crosses this barrier quite well. This is why IV oxy is *roughly* equipotent with IV morphine, despite the fact that morphine's binding affinity is several times higher than oxycodone's.(according to the binding affinity thread on BL, morphine's binding affinity is is some 6x higher than oxycodone.

Again, I'm not sure how my post(s) irritated you, and certainly I don't know what is "outlandish" about any of it. Frankly I think you'd embrace the truth in any form. But sorry if something's not clear. I'll attempt to rectify any problems sir!!! ?
 
Are you joking? "Outlandish claims"? Seriously? I've posted refs in different threads, hell I'll post more. But what is outlandish about it? Oxy BA varies from 40-90%, oral H BA is dose dependent, and can range from as low as 20%, to 75% at high doses.

Remember, oral diamorphine is 1.5-2x as potent as oral morphine. Guess what? Oral oxycodone is 1.5-2x as potent as (chronic) oral morphine. That by extension makes oral H and oxy on par.(At least at high doses).

And I've already discussed in detail that rectal oxycodone is absorbed more slowly than oral, with a longer tmax, and lower cmax. The trade off is that it has a longer duration than either IV or PO.

If you didn't like IV oxycodone, that's your business. And injecting any pill carries risks, so it's really a good thing. But in my experience, anyone not liking IV oxycodone either has a very high tolerance, it didn't do enough. But I myself think oxycodone is overrated, I am just trying to get the FACTS out there.

As you well know, everyone is different, and everyone is entitled to do oxy(and all other drugs) they're own way.

I just don't understand your attitude, I explain everything I post and have no problem posting references l, which I have done many times. If you don't like IV oxycodone, fine, I mean really it's good you don't, but it doesn't make anything I say less true, and you certainly don't need to get an attitude, I'll happily discuss and back up any claim I make.

And I don't know what the meth thing is about. As for the "bbb", clearly the CNS penetration is the same regardless of route. But oxycodone crosses this barrier quite well. This is why IV oxy is *roughly* equipotent with IV morphine, despite the fact that morphine's binding affinity is several times higher than oxycodone's.(according to the binding affinity thread on BL, morphine's binding affinity is is some 6x higher than oxycodone.

Again, I'm not sure how my post(s) irritated you, and certainly I don't know what is "outlandish" about any of it. Frankly I think you'd embrace the truth in any form. But sorry if something's not clear. I'll attempt to rectify any problems sir!!! ?

Lorne, while I Read that you have previously cited your sources, I kindly attempt to not be nagging while pointing out that this would be a great time to whip those bad boys out. The IV vs Oral oxycodone debate has long been heated.

Many know I am Rxd a fairly large amount of Roxicodone 30s. Besides having near fatal health consequences from a roughly ~1500mg a day IV habit a few years ago, shooting these is my preference for my pain relief. While there is no traditional hydro/dia morphine rush, the instant onset surely rockets me up rather sharply. I find the legs to be secondary to heroin and IMO is awesomely energizing. Oxy is a unique opiate for me in that regard. Without getting too off topic, let me respond with my point. Now that ER Oxycodone is for all practical purposes uninjectable, 30mg roxies are all that's left for IV users still in love with this particular chemical. This only adds to the debate because for the vast majority of users, the oral BA is certainly noticeably high. Gone are the days of getting seriously reckless with a 160mg shot of OC for the cheap. With only Blues available the situation isn't as much of a "premium" iv experience as it used to be. I fill Actavis and they truly don't help shoot themselves. Obviously I love the high but they're no OC 80s...

I hope u guys see where I'm coming from. Large #s of people who shoot roxies began during the great Florida pill rush with OCs. The ones still prescribed, like myself, have a difficult time IVing anything over 120mg of IR oxycodone because of the consistencyof A215S and Vs. I dodon't see as many malli around anymore. I think where we are in "abuse deterrence" (*ahem* fxck you, DEA) in this period of time calls in question affordibility and practicality.

>>>> lorne I'm waiting patiently on those sources

>>>>> PS don't shoot FIVE MG ROXIES that's a lot of filler for such a small reward. I go as far as finding anything under 30mg inadequate. If you come across Green a214s, crush them in a shot glass and take a shot of 15mg roxies with sum cherry coke. Too much filler you don't want that shit floating in your bloodstream
 
^^^ Don't worry, Space, I"ll be posting multiple references today. I mean the fact that a fucking mod would be so rude is, to me, outlandish.

Anyway, to start off:

http://www.ncbi.nlm.nih.gov/m/pubmed/1485370/?i=3&from=/1424423/related

Just a small study, which compared oxycodone via the oral, rectal and of course, intravenous routes. My main purpose for posting this link is to demonstrate one of multiple studies indicating that the BA of oral oxycodone is less than is often reported(closer to 50 than 87%). According to this study, the BA's of both the oral and rectal routes were LESS THAN 50%.

Of course one study is never enough to be sure of anything, but the same is true for the 87% figure often cited, and this is not the only study reporting a lower BA for PO oxycodone.
 
http://www.ncbi.nlm.nih.gov/m/pubmed/18945270/

They're is a study, confirming that the bioavailability of high-dose diamorphine is over 60%. And note that this isn't just an abstract, as the full text available, and the link above has another link to the full text, though all the important info is in the abstract.

As I said, oral H is 1.5-2x as potent as oral morphine, and oxycodone is also 1.5-2x as potent, which would make them (gasp!) equipotent. But I guess that is outlandish, whahaha!!!

Here is the relevant section:

RESULTS: The maximum plasma concentration (C(max)) of morphine was twofold higher after oral diacetylmorphine than after morphine administration in both groups. However, morphine bioavailability was considerably higher in chronic users [diacetylmorphine 45.6% (95% confidence interval 40.0, 51.3), morphine 37.2% (30.1, 44.3)] than in naive subjects [diacetylmorphine 22.9% (16.4, 29.4), morphine 23.9% (16.5, 31.2)] after low oral doses (48.5 micromol) of either diacetylmorphine or morphine. Morphine clearance was similar in both groups. Moreover, oral absorption of morphine from diacetylmorphine was found to be dose dependent, with bioavailability reaching 64.2% (55.3, 73.1) for high diacetylmorphine doses (1601 micromol).
 
Well the 'best' way is to probly just eat it, but I never do that unless it's a Percocet or some mixture with tylenol/ibuprofen in it. My favorite way to do it is IV, and although many claim it doesn't have a rush, it does to me. I have hydromorphone and Morphine to compare it to(no heroin to compare.) And obivously the rush is not as good as Hydromorphone or morphine(sometimes found that to be unconfortable with the histamine release.) But I enjoy it. BUT since I am trying to obstain from IV snorting comes to second for me. I found it pretty much last as long as oral AS LONG as I snort some water 5-10 minutes after I snort it. Would just eat it, but I prefer the quicker onset and just like to snort them, fun times. On Bupe now, so when I do use it's never as intense no matter what way i do it on the few days outta the month I decide to go on vacation. But for HR, just eat them, or plug them. Plugging seems to last longer than oral for me...
 
^^^ yes, as I've already mentioned, rectal oxycodone has a longer half-life than oral/IV(and again, the oral/IV half-life is exactly the same). The trade-off is that it takes much longer to take effect(tmax of 2-3h vs 1.5-2 for oral) and it has a lower Cmax.
But, a longer duration. I'm looking for a ref now(and it's like that with most opioids, rectal having a slower onset, but longer duration, though no one seems to want to accept this :(

Ok, here we go, I've posted this before, but what does that matter??? ;)


(Note how in the ref below, they refer to the BA of oral/rectal being 47-62%, which is what most studies agree with)...

Rectal oxycodone provides effective analgesia for patients who have difficulty swallowing or in whom the oral dosage form is contraindi- cated. Limitations of rectal administration include erratic absorption, limited patient acceptance, and a longer absorption lag time and time to Cmax than oral tablets (Tmax 3.1 hours vs. 1.5 hours).13 This may be the result of poorer blood supply to the rectum and a smaller surface area for drug absorption as compared to the upper gastrointestinal tract. Lo- cal irritation may develop at the absorption site, and an anorectal rash may limit its use after some weeks.13 The bioavailability of rectally ad- ministered oxycodone suppository (47 to 62%) is similar to orally ad- ministered tablets; however, there is large interpatient variation.13,33 This suggests that either there is no significant difference in first-pass effect of oxycodone when administered rectally or there is incomplete absorption from the suppository.

Source: The pharmacokinetics of oxycodone., J Pain Palliat Care Pharmacother. 2004;18(4):17-30.
 
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1381353/

I'll elaborate shortly...



Abstract

1. The pharmacokinetics and metabolism of oxycodone were studied in nine healthy young volunteers in a cross-over study. Each subject received oxycodone chloride once intramuscularly (0.14 mg kg-1) and twice orally (0.28 mg kg-1) at intervals of 2 weeks. A double-blind randomized pretreatment with amitriptyline (10-50 mg a day) or placebo was given prior to oral oxycodone. 2. The concentrations of oxycodone, noroxycodone and oxymorphone in plasma and the 24 h urine recoveries of their conjugated and unconjugated forms were measured by gas chromatography. 3. No differences were found between treatments in mean Cmax and AUC values of oxycodone which varied from 34 to 38 ng ml-1 and from 208 to 245 ng ml-1 h, respectively. The median tmax of oxycodone was 1 h in all groups. The bioavailability of oral relative to i.m. oxycodone was 60%. The mean renal clearance of oxycodone was 0.07-0.08 l min-1. The kinetics of oxycodone were unaffected by amitriptyline. 4. The mean ratio of the AUC(0.24 h) values of unconjugated noroxycodone to oxycodone was 0.45 after i.m. oxycodone and 0.6-0.8 after oral oxycodone. Plasma oxymorphone concentrations were below the limit of the assay. Eight to 14% of the dose of oxycodone was excreted in the urine as unconjugated and conjugated oxycodone over 24 h. Oxymorphone was excreted mainly as a conjugate whereas noroxycodone was recovered mostly in an unconjugated form.

So as you can see, according to this study, the bioavailability of oral oxycodone, in relation to IM, was 60%. As we all know, IM is (almost) always slightly less than IV; with oxycodone, I believe IM is 85-100%. So that would make the oral BA(relative to IV) like, what, 45-60%? Certainly nowhere near 90%. Are you satisfied yet, Tricomb??? ?
 
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