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Opioids Best Way to Take Oxycodone.......

^

1: dont believe so either, I've always thought it goes down into the stomach after dripping down the throat

2: pretty much answered your own question there, but also how soluble the drug is, individual first-pass metabolism, and low stomach PH can affect it too
 
I know most gets stuck in back of sinus, but I mean some has to be traveling with the air and get past...I suppose it wouldnt really matter if it made it in the lungs though, your body breaks down matter there too...

So to clarify, you want HIGH PH in stomach for oxy?
 
Those pills that are really chalky go into your lungs big time next time you snort a perc, T3 or vicodan blow out right away and a cloud of white dust will blow out of your lungs. Even smaller amounts can go into the lungs and damage them which is a downside to insufflation. It is quite a big deal actually it makes you hack up crap all the time.
 
My understanding is that many drugs are absorbed faster and at a larger % when the PH of the stomach is increased. (This goes for Oxycodone and other related)

This is not true for ALL drugs though, I believe.

Btw: taking a couple antacids with it can help it absorb faster
 
Those pills that are really chalky go into your lungs big time next time you snort a perc, T3 or vicodan blow out right away and a cloud of white dust will blow out of your lungs. Even smaller amounts can go into the lungs and damage them which is a downside to insufflation. It is quite a big deal actually it makes you hack up crap all the time.

Not to mention no one has talked about the BA of it in your lungs =P

Also, one of the arguments is that when you snort, yes high is slightly higher faster, but it makes it so that you adjust to it, and kind of ruin future experiences a bit. In regards to the BA...even it was twice as low as oral, I dont think it would really matter if it only takes you half as much. But I prefer oral for other reasons that just BA...
 
My understanding is that many drugs are absorbed faster and at a larger % when the PH of the stomach is increased. (This goes for Oxycodone and other related)

This is not true for ALL drugs though, I believe.

Btw: taking a couple antacids with it can help it absorb faster

Yes, all opioids are alkaline, which means that they absorb faster and more efficiently in a basic environment(IE: high ph)

A
@visceral: I can't read your last message, but if your at a point where 3mg made you feel normal, I would take 2ng today, and go from there.

Though maybe it's a little late for that!
 
^ When i asked what ROA is best i was said that oral consumption is best, but since i'm naturally curious and knew it'd never take them intranasally nor IV/IM (and if so, Tabs would be the very last thing ending up in my veins/muscles), i simply tried both ways. And while the oral Route was fine, it was not nearly what i was hoping for, so i tried them rectally and found it way intense, hence BA must have been higher this way! So even if studies state something different than that, i subjectively came to the conclusion that BA with rectal Administration must be higher - at least for myself! Why 'for myself'? Because BA is notably influenced, but rarely if ever mentioned, by many personal factors (metabolism etc.). So that could just mean that

a. my ass can process them better as my stomach does =D
b. those obstinately claim oral ROA is best do this because it's purely based on studies, but don't incorporate important personal factors

Mine are based on personal experiences and that's why i suggest that if one is curious to see what's best, just try what Route(s) is/are viable and see what works FOR YOU!
 
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Okay... I take my hat off to Lorne... It took longer than expected to come on last night, probably an hour, but was actually quite intense and lasted well on into the early hours of the morning.

I'm going to admit defeat and say that insufflation was definitely as good as, if not better, than ingesting it.
 
Id agree for pills with no APAP, snort that shit all day imo

but stuff with APAP should never be snorted

its really not that complicated
 
My back's been killing me today, been on my feet all day.

Just tried it again, only 2x5mg rails this time as I've not long ago taken a fair dose of MS Contin and want to keep my dosage down as low as possible.

Onset has been much faster than last night, can feel my arms getting warm/fuzzy/heavy at only ~15 mins. Not sure why...

Quicker than oral administration which usually takes ~60 minutes.
 
Even if snorting seems or actually really is 'better' as dosing the same Amount orally, which i've no reason to doubt so far, and when so many ppl affirm their experience and we now incorporate the frequency of these occurrences, the logic conclusion must have something to it (i.e. snorting Oxycodone, at least to some extent, having a higher bioavailability in comparison when administered orally) - and even though it still remains somewhat arguable, because it's not acutal fact as when this is being compared to proper scientific studies that have been made in the past, but a collection of personal experiences- those studies, which i also have not the slightest doubt of being very valuable reference points and something that has to be considered, are unfortunately often kinda misused by those, simply to defend their position about this disputable Topic and believe what they say, mean and think, counts for everyone - when the much more interesting question is, if 'better' is not confused by the fact that this well-known to provide a very fast onset ROA (along with the highly superior rectal administration) makes ppl belief the actual bioavailability is higher, which could be - but only if, besides the faster onset, the analgesic properties are the same or better - just as the overall duration of effects of said substance!

Whatever it is or may be, the inevitably onset of effects, even more prominent when the dose has been taken rectally (mostly confirmed by IV/IM-Users) especially after they ceased taking the Compound via this Route, is almost non-existent when taken the oral way, or more precisely said at least not to a comparable degree! That said, if you don't wanna snort Pills along with some of the nasty fillers they cointain and if you have no problem sticking a minuscule 1ml syringe up your backdoor - try that (after you emptied this region, which means going to the bathroom beforehand!). I don't and never will (i just hope i never did!) advise ppl to do drugs but surely recommended routes, so just for the sake of your own health please think about those fillers in the Pills, some of them being really bad in fact, even more so if they enter your respiratory system which is something you can't avoid - a common downside of snorting, nevermind what it is - railing crushed pills is worst and extremely unhealthy!

I bet my Ass that if you get over it that you stick something up your ass (2-3cm max.), and if it's that bad remember that the procedure is over in a few seconds - what follows shortly after that is payback BIG TIME!!! <3

But be careful with the dose since the absorption via this Route is very high, better start low and up the dose if needed, because you can un-take what's in, and the consequences could be not nice, even fatal!

Remember that and take care!
 
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if you have no problem sticking a minuscule 1ml syringe up your backdoor try it.

I was always hesitant to try this. I've taken Fentanyl/Methadone/Oxycodone/Morphine/Tramadol/Dihydrocodeine/Codeine and without a doubt, the best high I ever got was from dihydrocodeine administered rectally. It was quite some time ago at the end of my p/x and I had a fair amount left over, enough for an oral dose, but thought I'd just give it a try after reading a 'how to do it' thing on BL... wasn't the most pleasant feeling I've ever had, not the worst though. But the rush it gave me was the best I'd ever experienced, I think euphoria is quite a strong state of mind, and that's the closest I've felt to total euphoria. It sounds absurd when compared to Fentanyl/Oxycodone but it was incredible, and something I've never got close to achieving ever again. I think it was because that was a very long time ago when I had very little tolerance, (before I was put on Fentanyl/Methadone/MS Contin for spinal nerve pain relief).

I've tried it a few times after and never achieved that state, with anything. I was very short on my oral morphine once as I couldn't collect my p/x after work so I had to make 1 day's worth last 2 days when I was in absolute agony. Given the low bio-availability of oral morphine when ingested ( ~20-40% ), and the significantly higher bio-availability when rectally administered ( 35-70% ) it made sense *at the time* to split the dose into two and administer it rectally each day so I'd still be getting adequate pain relief on both days, but from a single dose.

Great in theory... in practice? 20ml of oral morphine up the bum made for great wet-sticky-farts and leakages! I only had a 10ml syringe so had to do it in two goes on the bathroom floor... I'm glad I can laugh about it now, it's quite funny in hindsight. Just an awful, awful experience! Some dihydrocodeine in 5ml of water is fine... 20ml of sticky oral morphine... no no no no no no!


I don't IV, never have done, never will do, so obviously the highs/rushes I've experienced wont ever be comparable to that of an IV user. I'm not a hardcore user in the slightest, I'm p/x'd pain meds for genuine pain so just like to abuse it every now and then.
 
Yea its all about preference I would only pop any pill that had apap in it now its just not worth it and takes away the euphoria/pain relief too much when snorting percs and stuff.
 
From what I've read, the bioavailability of oxycodone ingested orally seems to be equivalent to administered rectally.

Even if the bioavailability was the same, would administering it rectally provide more of a rush/quicker onset?
 
I have found the best way to take them is orally, right before a meal. By the time the last bite is down, the itchies and warm flushing comes on intensely. And is generally more relaxing since there's a full stomach of food in me
 
Even if snorting seems or actually really is 'better' as dosing the same Amount orally, which i've no reason to doubt so far, and when so many ppl affirm their experience and we now incorporate the frequency of these occurrences, the logic conclusion must have something to it (i.e. snorting Oxycodone, at least to some extent, having a higher bioavailability in comparison when administered orally) - and even though it still remains somewhat arguable, because it's not acutal fact as when this is being compared to proper scientific studies that have been made in the past, but a collection of personal experiences- those studies, which i also have not the slightest doubt of being very valuable reference points and something that has to be considered, are unfortunately often kinda misused by those, simply to defend their position about this disputable Topic and believe what they say, mean and think, counts for everyone - when the much more interesting question is, if 'better' is not confused by the fact that this well-known to provide a very fast onset ROA (along with the highly superior rectal administration) makes ppl belief the actual bioavailability is higher, which could be - but only if, besides the faster onset, the analgesic properties are the same or better - just as the overall duration of effects of said substance!

Whatever it is or may be, the inevitably onset of effects, even more prominent when the dose has been taken rectally (mostly confirmed by IV/IM-Users) especially after they ceased taking the Compound via this Route, is almost non-existent when taken the oral way, or more precisely said at least not to a comparable degree! That said, if you don't wanna snort Pills along with some of the nasty fillers they cointain and if you have no problem sticking a minuscule 1ml syringe up your backdoor - try that (after you emptied this region, which means going to the bathroom beforehand!). I don't and never will (i just hope i never did!) advise ppl to do drugs but surely recommended routes, so just for the sake of your own health please think about those fillers in the Pills, some of them being really bad in fact, even more so if they enter your respiratory system which is something you can't avoid - a common downside of snorting, nevermind what it is - railing crushed pills is worst and extremely unhealthy!

I bet my Ass that if you get over it that you stick something up your ass (2-3cm max.), and if it's that bad remember that the procedure is over in a few seconds - what follows shortly after that is payback BIG TIME!!


id disagree wholeheartedly. i found plugging opiates to give me a shitty high (no pun intended), and its not worth all the extra "steps", if you will.

just my opinion, could be horribly wrong according to your theory
 
From what I've read, the bioavailability of oxycodone ingested orally seems to be equivalent to administered rectally.

Even if the bioavailability was the same, would administering it rectally provide more of a rush/quicker onset?

No. Contrary to popular belief, IN MOST CASES, rectal administration results in a slower onset, with a lower Cmax. The one benefit to this is that the half-life is longer, resulting in prolonged analgesia.

With oxycodone, oral tmax is 60-90 minutes, while rectal is 2-3 hours, but rectal lasts longer.

I'll try and post a ref, but I don't think I have time. Surely you trust me by now? :)
 
No. Contrary to popular belief, IN MOST CASES, rectal administration results in a slower onset, with a lower Cmax. The one benefit to this is that the half-life is longer, resulting in prolonged analgesia.

With oxycodone, oral tmax is 60-90 minutes, while rectal is 2-3 hours, but rectal lasts longer.

I'll try and post a ref, but I don't think I have time. Surely you trust me by now? :)

Interesting! Fair enough! Thanks once again :)
 
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