This question is as old as this site is. Yes yes I'm a green lighter but only because I had to get a new account. The BEST ROA is rectal. hands down. Go get an oral syringe, some lotion for the tip, a small cup to mix the crushed beads/powder in, and about 2-4ml of water. Then stick that bad boy about 2 knuckles deep in your bum and press the syringe slowly. Should hit hard in about 10 minutes. Ive been bumpin (yes pun intended) for two days now and I feel great.
In terms of harm reduction, you use less (roughly a half to a third of what you would), it hits fast and "clean" (not as many noticeable neg side effects imo) and it doesnt leave you craving more after you peak nearly as bad as other ROA, at least in my experience.