Opioids Best ROA for morphine sulfate 30mg

[Stan the man]

Round, white morphine sulfate 30mg pills manufactured by Roxane Laboratories, Inc.

Would railing these do me any good? Or are they like MS Contin and I have to plug them? Would 30mg be enough for someone with minimal opiate tolerance?

 

[tricomb]

Those are morphine IR, MSIR30mg.

30mg is more than enough for someone with minimal tolerance. You should still plug them because 30mg of morphine has a very hard time finding it's way into your epithelial walls amongst at least 200mg of filler/binders/inactive ingredients clogging up the works.

 

[Psychonauticunt]

Round, white morphine sulfate 30mg pills manufactured by Roxane Laboratories, Inc.

Would railing these do me any good? Or are they like MS Contin and I have to plug them? Would 30mg be enough for someone with minimal opiate tolerance?

I'm not sure of what you mean by "minimal" opiate tolerance - a little above zero, due to moderate use a little while ago; or that you generally react very strongly to even relatively small doses, despite the lack of acute tolerance.

Anyway, morphine has very poor intranasal and oral bioavailability, in the 30% region. Unless you are injecting, I suggest you plug. It's hard to get a good picture of your opiate tolerance with the information provided.

I consider myself to be slightly naturally tolerant; to get a nice (although underwhelming buzz), I'll take 300-390mg of codeine, or 300-400mg of tramadol (or more, but NEVER DO THAT - SEIZURE RISK! As I'm sure you're aware).

Having not had opiates for many months, and never used them more than very very rarely, I tried I.V. morphine for the first time. 10mg may has well have been placebo; I plugged another 10mg within 15 minutes and then felt a mild buzz, like maybe 90-120mg of codeine.

A few weeks later - surely after tolerance had subsided - I was injected with 40mg. THIS was something like I was expecting - not a tiny bit too much, but then again I'm larger than average. [DISCLAIMER: You should not I.V. 40mg of morphine if you have no tolerance].

Either way, I.V. is the most efficient ROA but you do need to know exactly what's in those pills, how to filter them out, and how to bang. Plugging them is your next best bet.

I might use 30mg orally for some kind of injury - but not even serious pain. With negligible bioavailability, oral morphine is a poor and wasteful formulation.

 

[tricomb]

hold on, are you saying you IV'd 40mg morphine with low tolerance? >_< Definitely not HR at its finest.

Morphine is for serious pain. Just because it has a low bioavailability does not make it "poor and wasteful". This just means you're not doing it right.

Morphine the gold standard for a reason, pretty much superior to all other opiates in terms of analgesia and unlimited ceiling limit, limited only by it's dose/response curve.

 

[phatass]

ROA bio-availabilities i've read are
IV-99%
pluged 65%
oral-35%
snorted 20%

 

[Tommyboy]

^ IV is always 100% since it is the ROA that the rest of the ROAs BAs are based off of (ahh, too many acronyms in one sentence). They take the plasma concentrations of a dose of the drug give via IV, and use that as the value for 100%. Then at another time they administer the drug via a different ROA and measure the plasma concentrations, and figure out the BA % in proportion to IV. Everything else seems accurate, not that your value for IV wasn't accurate, it was only off by 1%.

 

[tricomb]

Yeah even though you may not get 100% of the dose your administering, it's considered the maximum total amount your body processes, factoring in whatever loss you may have along the preparation process, which in the scientific studies done to assess the BA of morphine, is not an issue as it is a controlled environment every step of the way.

 

[Stan the man]

I know opiates are water soluble, could I not do a simple cold water extraction and then shoot it?

 

[Stan the man]

ROA bio-availabilities i've read are
IV-99%
pluged 65%
oral-35%
snorted 20%

Can morphine be smoked?

 

[kokaino]

Morphine can be smoked, but not in the form of morphine sulfate so you definitely can't smoke the pills.

The best ROA for these IR morphine pills is obviously IV, but that comes with extra risk and if you aren't experienced than I wouldn't recommend it. The next best ROA is rectal administration. Taking morphine orally or intranasally isn't going to yield the great high which morphine can provide, but if taken in the right doses, you can achieve an intense euphoric high even taking it orally (I have had some incredible experiences with oral morphine - its all about the dose). It's all about your tolerance level and the dose you take. You say you have minimal opiate tolerance, what's "minimal" opiate tolerance? How much hydrocodone or oxycodone can you handle orally?

 

[Psychonauticunt]

hold on, are you saying you IV'd 40mg morphine with low tolerance? >_< Definitely not HR at its finest.

Morphine is for serious pain. Just because it has a low bioavailability does not make it "poor and wasteful". This just means you're not doing it right.

Morphine the gold standard for a reason, pretty much superior to all other opiates in terms of analgesia and unlimited ceiling limit, limited only by it's dose/response curve.

Alright, you make a few good points. While I did allude to it by saying I have higher natural tolerance, and that I am quite large, I should maybe have stressed in the interest of harm reduction that you shouldn't try this at home. I felt very confident doing it and was quite sure I would be fine. Slight discomfort was what I was expecting, but it was less than that. However, I'd already gauged my tolerance with previous attempts and ascertained this to be safe, and had a more experienced (sober) friend watching. So I do apologize - I should have maybe underlined that this is not a good idea, prima facie, for non-tolerant individuals.

Also, what I meant by "poor and wasteful" - although you're quite right, I now disagree with my own words and would tone it down a notch - is that for getting effects with finite supplies of morphine, insufflating or ingesting it gets you much less in the way of effects (or fewer doses) than other ROAs. For legitimate pain relief, and if you have a steady supply, of course - eat them. But I was assuming this may be something other than ordinary medicinal use (correct me if I'm wrong), so I pointed out that other methods are more efficient. Doing it "wrong" or "right" is pretty subjective, but either way, I think you could make the point that if you only have one 30mg pill and you want recreational effects, oral consumption may even be doing it wrong - or there may be a more correct way, depending on your intention.

Anyway, thanks for pointing those out - I didn't explain myself very clearly.

 

[tricomb]

It may be harder to dose for recreational uses due to limited supply/amount, but I was talking about medical use, not abuse.

Morphine is probably the best pain killer we have right now, or ever will have, it's oral BA and 1st pass metabolism don't change that, it just calls for a dose titration.