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Best Pharmaceutical MAOI to combine with DMT?

Drench

Drench

Bluelighter
Joined
Mar 3, 2009
Messages
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Behind my decks
Hi, I was wondering what the best pharmaceutical MAOI is best to combine with DMT?

Two that I can get my hands on are -

Mocolobemide (Trima) - 150mg
Tranylcypromine (Parnate) - 10mg

Which out of the two would be the best?

What dose would need to be taken of each drug? Would it be before or after ingestion of the DMT?

Cheers, Drench.
 
No personal experience but Ismene's recommendation sounds good to me - Moclobemide is not known to produce any reuptake inhibitor effect which is good, seems to be pretty selective in its activity as an MAO-A and -B inhibitor and a brief wiki skim seems to indicate that it's pretty much contraindication free beyond the usual MAO-I concerns. Seems more or less ideal for pharmahuasca.
 
Why is Rue a better MAOi?

I havent tried either, but from all reports moclo is very clean and transparant feeling on the body while Harmala's come with bodyload.
Yet both potentiate DMT equally well.

I would just go with the less painful route.
 
If we're looking at natural MAOI's to use in conjunction with Ayahuasca would it not be most prudent to suggest the traditional Caapi vine?

Historically the shamans believe that there’s a divine intelligence in the plant, it guides and protects the user by revealing only what is needed and what one is capable of understanding and utilizing, not more, not less.

Whether you ascribe to the biological standpoint, or the spiritual, it is true that the Caapi Vine, and harmala seeds contain 'more'. Whether we're talking alkaloids or 'spirits'. The Mocolobemide will surely provide a more 'transparient' experience with 'the light'. But sometimes this light is better filtered as in a through a projector, to see what you were truly meant to see. Discomfort and additional nausea brought about by the natural MAOI's can surely fuel the dive into a deeper and more meaningful experience; however less pleasant it may be at the time.

If you just want to experience DMT, the synthetic MAOI should be fine.
 
^wow try to ignore the atrocious grammatical mishaps; I guess talking about psychedelics takes me to a rather spacey place.
 
I agree that harmala almost certainly contains alkaloids that do more than simply inhibit MAO-A and MAO-B and therefore probably offers a distinct experience, but I'd be careful about romanticising traditional myths and ascribing intelligence to any active compound. Harmala produces nausea because it's a psychoactive chemical, not because the intelligence behind it thinks you will learn more after vomiting. There is no such thing as what you are "meant to see" beyond what you or some other conscious being wants you to see. Your unconscious can seem almost like a benevolent external entity in that it can produce content that you were never conscious of creating and seems to have your interests in mind, but the meaning produced by a drug experience comes from within, not some plant-spirit controlling your experience. Any additional meaning gained due to physical nausea is about how you symbolically interpret the experience, but I would certainly never want to add nausea to an experience for this purpose. I am certainly skeptical of the idea that there is any specific thought, revelation, personal growth or other 'productive' result that could be had using natural ayahuasca but not pharmahuasca or for that matter, sobriety.
 
solistus said:
I agree that harmala almost certainly contains alkaloids that do more than simply inhibit MAO-A and MAO-B and therefore probably offers a distinct experience, but I'd be careful about romanticising traditional myths and ascribing intelligence to any active compound. Harmala produces nausea because it's a psychoactive chemical, not because the intelligence behind it thinks you will learn more after vomiting. There is no such thing as what you are "meant to see" beyond what you or some other conscious being wants you to see. Your unconscious can seem almost like a benevolent external entity in that it can produce content that you were never conscious of creating and seems to have your interests in mind, but the meaning produced by a drug experience comes from within, not some plant-spirit controlling your experience. Any additional meaning gained due to physical nausea is about how you symbolically interpret the experience, but I would certainly never want to add nausea to an experience for this purpose. I am certainly skeptical of the idea that there is any specific thought, revelation, personal growth or other 'productive' result that could be had using natural ayahuasca but not pharmahuasca or for that matter, sobriety.
Click to expand...

I would imagine that when you use a certain plant, you're affected by that plant's DNA as well. I would imagine that DNA is the most potent experiential molecule of all, but I could be wrong based on how one might define molecule. I think the source always matters, but you may certainly be getting at something quite valuable when you say that experience comes from within.
 
moclobemide seems to be used significantly more often than tranylcipromine, for that reason alone I'd choose it. I have some myself but not used it yet.
 
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