bayhead415
Bluelighter
- Joined
- Aug 24, 2012
- Messages
- 254
What I mean is that oxymorphone is more sedating without other side effects in my opinion. In an article I read it mentioned that oxymorphone bound more selectively to µ receptor vs κ & δ receptors and I think meant it mean it mostly bound to the first and very little to the second two where as all the other morphine compounds bound to κ & δ as well as µ. If I can find the article again I will post it here as it LITERALLY described every opiate and compared all of their pharmacological aspects as well as described the 3 different receptors and what is caused to the activation of them. I learned there was 2 µ receptors with one only inducing sedation while the second induced analgesia, nausea, and the other physical effects as well as the ones including side effects. In my experience it is literally the only opiate that has a true sleep inducing and sedative effect and I have used morphine, heroin, and dilaudid in low and extreme doses and NEVER getting close to the sedating effect oxymorphone nasal or orally no matter how I took the other compounds exluding IV. It leads me to believe that it binds strongly to the µ receptor that only causes sedation vs. the one that causes the other side effects, but I have no scientific evidence backing this up.
Edit: http://www.painphysicianjournal.com/2008/april/2008;11;S133-S153.pdf here it is. Scroll down to the bottom near the conclusion for the different opiate comparison and ther receptor activation and near the top for the table that descripes the different opiate receptors. although I am sure this article is a great read. Personally I do not have the time to do it right now in my life.
Also here is the quote "Oxycodone has activity at multiple receptors, but
oxymorphone has high affinity for the µ receptor with
negligible interaction with κ and δ receptors"
"• Mu 1 – Analgesia
• Mu 2 – Sedation, vomiting,
respiratory depression, pruritus,
euphoria, anorexia, urinary retention,
physical dependence"
Looks like I made a mistake the 1st one is selectively analgesia, while the 2nd is sedation so it must bind to the second strongly if not both of them. As I said I barely skimmed it while I was looking for oxymorphone rectal bioavalibilty.
Edit: http://www.painphysicianjournal.com/2008/april/2008;11;S133-S153.pdf here it is. Scroll down to the bottom near the conclusion for the different opiate comparison and ther receptor activation and near the top for the table that descripes the different opiate receptors. although I am sure this article is a great read. Personally I do not have the time to do it right now in my life.
Also here is the quote "Oxycodone has activity at multiple receptors, but
oxymorphone has high affinity for the µ receptor with
negligible interaction with κ and δ receptors"
"• Mu 1 – Analgesia
• Mu 2 – Sedation, vomiting,
respiratory depression, pruritus,
euphoria, anorexia, urinary retention,
physical dependence"
Looks like I made a mistake the 1st one is selectively analgesia, while the 2nd is sedation so it must bind to the second strongly if not both of them. As I said I barely skimmed it while I was looking for oxymorphone rectal bioavalibilty.
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