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Misc Benzos Vs. Alcohol

I

illn3ss

Greenlighter
Joined
Apr 29, 2013
Messages
36
Who wins? And what about differences in chemistry concerning GABA receptors, if there's any nerds out there.
 
Last edited:
opi8 said:
In a fight? I'd say alcohol easy.
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I say benzos cause you don't throw up. The main thing is too even out your dosages so you don't blackout and actually feel the high. To me alcohol tastes like shit. I believe if Jesus came back he would approve of Xanax as a replacement for the blood of Christ. Do you think its bad that I took 9 bars with someone I don't really trust? (it was throughout the night). And a futhur question, which drug can you keep your basic instinctual "flight or fight" mode when blacked out on heavy dosages or either substsances? Or is there not a difference? Aren't they both the same shit? They both affect GABA receptors, but in what way do they differ in the way they release GABA in the brain?
 
Alcohol is more sedating earlier off because it is a dirty drug. It gets fuzzy and disorientating. It hits more Inhibitory receptors than benzos.

Benzos are clean all the way up until you are blacked out. It's very easy to forget you have taken them.

They are both terrible at maintaining a level of inhibition at higher dosages.

They both lay well within the same category of effects, but as far as destruction to the brain itself, alcohol takes the cake.

Benzos are relatively benign if taken properly.

You can keel over and die from too much alcohol.

It's damn near impossible to consume a lethal dose of many mainstream benzos without losing consciousness. Combining them with other sedatives is on the other hand multiplying the fatality of both said drugs.
 
Psychedelic Jay said:
Alcohol is more sedating earlier off because it is a dirty drug. It gets fuzzy and disorientating. It hits more Inhibitory receptors than benzos.

Benzos are clean all the way up until you are blacked out. It's very easy to forget you have taken them.

They are both terrible at maintaining a level of inhibition at higher dosages.

They both lay well within the same category of effects, but as far as destruction to the brain itself, alcohol takes the cake.

Benzos are relatively benign if taken properly.

You can keel over and die from too much alcohol.

It's damn near impossible to consume a lethal dose of many mainstream benzos without losing consciousness. Combining them with other sedatives is on the other hand multiplying the fatality of both said drugs.
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Well how does 9 bars taken over a period of around 3-4 hours compare to a benign dosage? And also would I be able to defend myself? Somewhere I heard that you inhibit a werewolf like mindset, as in pcp. For the record, my friend (who I don't really trust) took a video of me trying to smoking the cord to an xbox controller, but I was conscious nevertheless. I guess my main question is, would you be able to remember to wake up after a traumatic experience, such as a gun being pulled on you? I do remember when I got my DUI (I was on allot of ativan, all I remember is taking the pills than my other friend slam the door on me cause I was driving retarded. Would Xanax work the same way? At an 18 milligram dosage being conscious? 8(
 
alcohol is useless for me now..it just makes me slower, groggy, not wanting to do much of anything..at least with benzos i get very relaxed with a clear head and no 'dirty buzz' type feeling..neither drug is good for party atmosphere for me anymore though..
 
Not just that the pharmacological profil is totally different, Alcohol is neurotoxic and Benzodiazepine are incredibly non-toxic.

Both Alcohol and Benzodiazepine are positive allosteric modulator of GABAa receptor and produce a very similar effect on the receptor causing anxiolytic and sedation, I would say both do the same effect on the receptor but Benzodiazepine are MUCH more potent since you only need a few milligrams to get the effect and you have to drink a lot of alcohol to have the same effect.

Alcohol have a very complex pharmacological profil, it affect

GABAa as a positive allosteric modulator
NMDA, AMPA, Kainate Glutamate receptor as an antagonist
Potentiate 5HT3
Potentiate Glycine
Antagonise nicotinic ACh receptor
Inhibit sodium and calcium voltage gated channels and activate potassium channels

So the effect are very different but on the GABAa receptor Benzodiazepine are much more potent by weight.
 
QUARE said:
Not just that the pharmacological profil is totally different, Alcohol is neurotoxic and Benzodiazepine are incredibly non-toxic.

Both Alcohol and Benzodiazepine are positive allosteric modulator of GABAa receptor and produce a very similar effect on the receptor causing anxiolytic and sedation, I would say both do the same effect on the receptor but Benzodiazepine are MUCH more potent since you only need a few milligrams to get the effect and you have to drink a lot of alcohol to have the same effect.

Alcohol have a very complex pharmacological profil, it affect

GABAa as a positive allosteric modulator
NMDA, AMPA, Kainate Glutamate receptor as an antagonist
Potentiate 5HT3
Potentiate Glycine
Antagonise nicotinic ACh receptor
Inhibit sodium and calcium voltage gated channels and activate potassium channels

So the effect are very different but on the GABAa receptor Benzodiazepine are much more potent by weight.
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Do you think doing 9 bars overnight with someone I didn't really trust was a smart idea? lol
 
Mr.Scagnattie said:
^^^

You took 18mg's of alprazolam in one night? 8( Did you end up waking up in a jail cell naked covered in peanut butter?
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No although I did wake up in jail after taking an unknown amount of ativan couple years ago. My friend actually took a video of me and I attempted to use the end of an xbox controller to light up a bowl. I woke up in bed feeling normal.
 
For me personally, it depends largely which benzo you're talking about. I'm a bit unusual in that I actually prefer Temazepam and Nitrazepam to, say, Diazepam or Alprazolam. Not sure why, just my personal preference. Although not technically a member of the benzo family, I'm partial to Etizolam too. So yeah, I suppose my choice here would be to reach into the benzo horde in my cupboard as opposed to the beer in my fridge.
 
Actually, because I done Benzodiazepine in a very high dose for the first time about 15mg of Lorazepam (Ativan) for the first time of my life I end up black out in a my friends car with my friend (not the one who was driving) who did a little less then me and we were totally fucked up. I dont really know how it ends but I did wake up in my bed and not in jail. But its not how it always end, theres real Phenazepam report that really end in jail so I would suggest not abuse too much Benzodiazepine since then cause Amnesia and total inhinbition that leading to dumb action which you might regret after your trip.
 
....and this is why i love benzos! haha

on a side note, what's the consensus for z-drugs? half a bar of zolpidem (5mg) feels like im 10 beers deep. if used with little bit of alcohol, i usually puke within 15 minutes and pass out. on the other hand, zoplicone (3.75mg) with a couple a beers often renders a black out experience, in which i would go ape-shit. only remember bits and pieces of the night. one time, i had gotten back from a party and should've just went to bad, but i ended taking my car keys and went for a ride. did several donuts outside my house and crashed into an utility pole few blocks away. i had no recollection of the events that took place, i had to do some investigative resarch myself to pick up on the clues and needed the police report to fill me in on the rest of the details.
 
Personally, I've never had much recreational experience with zed-type drugs. Here in Wales, when hunting for free benzos (prescriptions here are free of charge) the standard prescription is a box of Temazepam, although in the past I've been dumped with 14x 7.5mg Zopiclone. Washed 3 of them down with a beer. Next thing I know I woke up in the morning, and have absolutely no bloody recollection of any activity which took place in-between, although my housemates report another tale entirely. I don't find them anywhere near as recreational.
 
^ well 3x 7.5mg zopiclone is a bit heavy innit? i have to say though, i find z-drugs far superior than benzos in the recreational department. then again, i usually don't just nod off, i would boost with amphetamines or cocaine. im glad to say those days are long past me though.
 
I have to admit, it was a 'brave' (or foolish) dose to start with, and it did totally floor me with the booze. Do you personally get the full muscle-relaxant properties with zed-type drugs that most people experience with certain benzos, or just the mental relaxation and sedation?
 
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