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Benzodiazepine Raw Powder Solubility

kidamnesiac said:
dissolve it in alcohol, pour as a liquid onto whatever solid powder you want (it doesn't fucking matter), stick into a mixer or mix like hell by hand, let dry for a while, cap with a cap'm'quik, sell to all your buddies. got it? NOT ADVANCED.
or just lay on blotter and pick up from the distribution part. want us to help sell any other drugs for you?
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I could do without your sarcasm and mis-information. I don't sell drugs, I only use them. I have a script for clonazepam but its not quite enough for my agoraphobia (yah google it 8)) Please save your nonsense for the Basic Fourm

-Jamshyd, I've tried alot of the different benzo powders, TRUST me I'm fully aware of their solubilities, atleast the ones I've handled. Thanks for the concern though.

:DDutch
 
Unfortunately, Jamshyd is absolutely CORRECT:
"Lorazepam: colourless, crystaline powder; practically insoluble in water, slightly soluble in ethanol, hardly soluble in methylenechloride."
(taken from a handbook on analysis of pharmaceuticals; a quite reliable source)
 
Some other 1,4-benzodiazepines from the same book:

- Bromazepam: practically insol. in water, slightly sol. in ethanol and DCM (=methylenchloride)

- Chlordiazepoxid: slightly sol. in ethanol

- Clonazepam: practically insol. in water, slightly sol. in methanol and DCM, hardly sol. in ether

- Medazepam: good sol. in ethanol

- Midazolam: practically insol. in water, easily sol. in acetone and ethanol, sol. in methanol

- Diazepam: nearly insol. in water, good sol. in ethanol

- Flurazepam-HCl: good sol. in water, sol. in ethanol, insol. in ether

- Flunitrazepam: practically insol. in water, sol. in acetone, hardly sol. in ethanol

- Lorazepam: practically insol. in water, slightly sol. in ethanol, hardly sol in DCM

- Nitrazepam: insol. in water, sol. in alkaline aqueous solutions

- Oxazepam: practically insol. in water, hardly sol. in ethanol and DCM

- Temazepam: practically insol. in water, easily sol. in DCM, sligtly sol. in ethanol

Please note that if the substances are present as salt (like the mentioned flurazepam-HCl), solubility in water/MeoH is normally drastically increased, while it is decreased for DCM. Exceptions are possible.

Murphy
 
CaptainBenzo said:
I'm trying to figure out what what hydrophilic (water soluble) intermediate I should use, maize starch, sodium starch glycollate, or just lactose.
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Errrrrm...I don't get it. That sentence doesn't make sense to me...Explain plz.
 
MurphyClox said:
Errrrrm...I don't get it. That sentence doesn't make sense to me...Explain plz.
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Thanks for the great info MurphyClox. Can you add Alprazolam to that list please??

What I was asking was what can I add to the powder so that I can consume it with the most effective results.

-Dutch
 
CaptainBenzo said:
Hammilton....Always blowing up my spot, wait until I have enough posts to private message you.
You'll know who I am, until then please keep that sarcastic shit to yourself. (1)
Were are not all in college for chemistry like you. We are here to learn because of this. Not to make ourselves feel superior to people who know less about that subject. (2)Please use your knowledge to help people learn without trying to lower our self esteems (3)

8)Dutch
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(1)Do you think that if I knew who you were (as if I don't) I'd care? (2) All of us have better things to do than to help people who think their benzos will evaporate with ethanol make pills for public sale. You've been working on this for almost a year now, no? You still haven't gotten making pills down? I really thought you'd have been arrested by now. (3) How do you lower an agoraphobic's self esteem???

If this was about anything but helping you make some cash on home made pills, I'd definitely providei answers. Except it's not.
 
Oh and from personal experience:

Alprazolam - Very Soluble in Ethanol

Diazepam -Decent Solubility in Ethanol

Clonazepam- Very Soluble in Ethanol

-Dutch
 
Hammilton said:
(1)Do you think that if I knew who you were (as if I don't) I'd care? (2) All of us have better things to do than to help people who think their benzos will evaporate with ethanol make pills for public sale. You've been working on this for almost a year now, no? You still haven't gotten making pills down? I really thought you'd have been arrested by now. (3) How do you lower an agoraphobic's self esteem???

If this was about anything but helping you make some cash on home made pills, I'd definitely providei answers. Except it's not.
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1) You should we've chatted alot via PM and Phone. I wouldn't classify us as friends. However we had an understanding

2) Quit while you behind. I'm a firefighter and I was in a real bad explosion that almost killed me, it left me with 3rd degree burns on 25% of my body. I didn't get arrested, I don't do anything illegal.

3) HUH??? What people with agoraphobia don't have self esteems??
I guess you have a minor in psychology.

Please stop being a troll, that talks a big deal online, I know you...I understand why get on here and try to bully people with you psycho bable. I don't need your help and I never asked for it.

Please, If you have nothing productive to say, just keep your comments to yourself.

Thanks,

-Dutch
 
Alprazolam: Solubility in water is 40 mg per liter...that is next to nothing and would be best describes as 'hardly soluble'.

A mixture of acetone/hexane is useful for recrystallisation of the free base.

Note: I will stop posting in this thread if the accusations continue...Go to the social club and deal it out over there, both of you. It's 'pissing me off' to post my stuff between the personal pitfights of some board members. Sorry to say so, and sorry for the rude words.

Murphy
 
I found that the best thing to dissolve benzos in for rectal admin. is MILK. Yes, milk (the higher the fat content, the better). I think F&B will agree with me on this one.
 
...which is in compliance with the overall lipophilicity of all benzos. I would agree, too, but I have never tried it.
 
Jamshyd said:
I found that the best thing to dissolve benzos in for rectal admin. is MILK. Yes, milk (the higher the fat content, the better). I think F&B will agree with me on this one.
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Thats kind of brings out my main question. Is it as simple as adding lactose powder to the raw benzo powder and inserting the mixture into capsules.
or do i need to add a disintegrant such as sodium starch glycollate??
I'm not really down with the HOLE "rectal" thing:\

Murphy I applogize on behalf myself and these other people. I guess because of the nature of the drug people assume I have criminal intentions, I assure you I don't. If I was trying to make potassium tablets it would be another story, however I would be in the same boat (as far as uncertainty of how to make power comsumable).

I greatly appreciate all helpful input!
:)Dutch
 
Just tell us EXACTLY what end product you want to make with the raw benzo powder, and then we can probably help you.

If you're just trying to add a "bulking" agent to increase the amount of powder per dose, get some inositol, lactose, or hell, just crush up some melatonin tablets. Mix em together and stir. Voila!
 
Well, you're missing out. 10mg rectal Diazepam is every bit as good as 20mg orally, and has a much faster comeup.

Anyway... again, I'm sorry to say that these questions make me very scared of the many different ways you could screw up due to lack of knowledge...

You tell me: a pill has 10mg diazepam and, say, talc and starch. Another pill has 10mg diazepam and has lactose, talc and starch. What is the difference?
 
You guys are right, lorazepam's water solubility is quite low: 0.08 mg/mL @ neutral pH. This is perhaps twice the solubility of alprazolam, but still very low. Those stupid emedicine toxicity write-ups will often refer to lorazepam as "water soluble", which is misleading...

The solubility of alprazolam increases greatly in an acidic solution :12 mg/mL @ pH 1.2, compared to 40mg/L @ a neutral pH.

As wungchow mentioned, what is the end use? I don't believe you need to add lactose/etc to the tablets to "activate" the drug as you seem to be suggesting. If this is just for ease of handling, why not put the alprazolam on blotter paper...
 
http://www.usdoj.gov/dea/programs/forensicsci/microgram/mg0508/mg0508.html

Microgram said:
XANAX BLOTTER PAPER IN BARTLESVILLE, OKLAHOMA


Photo 1 (12 of 86 squares)
The Oklahoma State Bureau of Investigation Northeast Regional Laboratory (Tahlequah) recently received a partial sheet of blotter paper, with a Xanax tablet shape with the word “XANAX” inside the tablet shape imprinted repeatedly on one side (see Photo 1) and the word “XANAX” imprinted repeatedly on it in bold letters on the opposite side (photo not shown), suspected LSD. The exhibit was seized in Bartlesville by the Washington County Sheriff’s Office, pursuant to a traffic stop for suspected DUI (Bartlesville is in the northeast corner of the state, near Tulsa). The sheet contained 86 dosage units, segmented into ¼ inch squares. UV irradiation did not give the bright fluorescence usually observed with LSD blotter paper, and analysis of methanolic extracts by GC and GC/MS indicated not LSD but rather alprazolam (not quantitated, but a moderate to high loading based on the chromatograms). A similar submission was previously submitted to the laboratory; however, that exhibit consisted of only two squares, and was imprinted with “XANAX” on only one side. In the latter case, analysis again indicated a heavy loading of alprazolam.

[Editor’s Notes: Xanax is a trade name for alprazolam. Over the past five years, there have been numerous reports of blotter paper laced with drugs other than LSD, usually designer tryptamines and phenethylamines. However, use of benzodiazepines (such as alprazolam) for this purpose is unusual. Submissions of blotter paper actually containing LSD are currently uncommon.]
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I had no trouble dissovling phenazepam into propylene gycol and filling gelcaps with it....just check your particular gelcap to make sure it doesnt break down with the propylene gycol...and your good to go.

I used a bit of semi congelled gelatin to seal the two part cap. Its a pain in the ass, but if your only making a few to carry with you, its doable.
 
wungchow said:
Just tell us EXACTLY what end product you want to make with the raw benzo powder, and then we can probably help you.

If you're just trying to add a "bulking" agent to increase the amount of powder per dose, get some inositol, lactose, or hell, just crush up some melatonin tablets. Mix em together and stir. Voila!
Click to expand...

Corrected me if i'm wrong please. Since these raw powder forms aren't water soluble, I assume that means i can't just sniff or put the raw form into a capsule and get the desired effect. I'm thinking I need something added to make the body process the drug.

I figured it was clear by know my intentions as stated in post #1 to make my own capsules.

Ziddy, cool read up. seems it would be quite simple to make that blotter paper, I just wonder how they keep the dosages consistent.

-Dutch
 
Your body can process water-insoluble benzos just fine. You don't need to "activate them" in any way.
 
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