• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

befor (E) you roll

E

Euronymous

Bluelighter
Joined
Jan 2, 2006
Messages
104
i've recently seen this advertised at parites, apparently its supposed to rid your "e" hangover, i was fortunate enough to speak with an individual who was a promoter for the stuff and i asked him "How does this stuff combat the hangover?" He replys to me, "It works like a vaccine." OKAY



according to dictionary.com

vaccine - any preparation used as a preventive inoculation to confer immunity against a specific disease, usually employing an innocuous form of the disease agent, as killed or weakened bacteria or viruses, to stimulate antibody production.

im pretty sure an mdxx hangover is NOT a disease. and if your taking rolls that you don't even know what contents the pills are, how do you know that this stuff will provide the "correct" vaccine? theres sooo many dfferent contents of rolls(mda/mde/mdma/meth/gbh/coke/etc..) So is this vaccine some kinda supper vaccine that protects you from all substances? I personally haven't been able to experiment with it yet to see if it really does clear an E hangover, but i did try it while on 25mgadderall/20sack of K/minor achohol consumption) i had no sleep that night and felt reasonably good the next day, i even had to work at 11:30am that day, i mean i was lil a lil screwy in my head, but my mood overall was more than postive/comfortable. what the hell is in this stuff? and has anyone experimented?
 
Vaccine is the wrong term, definitely.
So what do this "E hangover cure" contain...?
I'm guessing just 5-HTP and amino acids and vitamins.
 
He was probably just trying to dumb down his explanation of how it works, and if you substitute "disease" and "hangover" in that definition then it almost is true.

Like Matt presumed it was likely 5-htp, a dietary supplement you can get anywhere. Of course this hasn't been proven by the FDA or anything, but what 5-htp does is convert directly into serotonin. So, while the roll is depleting the serotonin in your brain the 5-htp is refilling it. Since the depletion of the serotonin is what causes you to crash, this effectively keeps many people from having a hangover (and some have reported rolling harder as well because they have more serotonin for the E pill to act upon).

People are also known to take it as the roll starts to end, SWIM confirmed that this is just as effective for him personally and it really does work - he even said he felt buzzed the next day.

Just a warning, don't take too much or it will lead to Serotonin Syndrome (here are the symptoms). This doesn't happen often, and while I can take 300 MG and be fine YMMV so try it out at lower doses, working your way up before you use it rolling. If you feel any of the symptoms of Serotonin Syndrome at some point then you should not mess around with it. And save yourself some money and buy it at a health food store.

Hope this helps.
 
One of the main reasons MDMA has a notable hangover effect is that it destroys tryptophan hydroxylase - the enzyme your brain uses to convert trytophan (an amino acid) into 5-hydroxy-tryptophan (5HTP) -

Your brain the decarboxylates 5HTP into 5-hydroxy-tryptamine (or Serotonin)-

it is theorized that taking 5HTP will help the recovery process and possibly even minimize neurotoxicity by skipping the rate limiting step in the serotonin pathway (trypto-5HTP via tryptophan hydroxylase)-

It is still a theory since there are no proven studies that this works in people - although there is tons of info on it definitely boosting serotonergic storage of serotonin in mice (as well as interestingly dopaminergic storage of serotonin)-

peace
 
From my experience 5-htp does very little to prevent the comedown, i would go as far as attributing most of positive testimonials to the placebo effect. It may help somewhat in theory, but to be honest for some odd reason I feel almost better without it. I also think serotonin depletion is not the main cause of the comedown, there must be another mechanism in action. Having said that I dont really get depression after mdma, just some mental slow down and tendency for negative thoughts to be more dominate than usual, so it might just be me.
 
Hmm...So im guessing...its a more cost effective version of 5htp that you'd be buying at walgreens/cvs etc. The pills of 5thp can be rather costly(13$) and only have soo many pills(20at the most) before you roll cost about 20$ you only need one spray, and its a whole bottle, probably could last you much longer than a bottle of pills. Good point on the seratonin syndrome, defenitly don't want to overdo any sertongeric activity ecspecially when fucking around with MDxx. I think if people were to get pill testers before they drop beans and take this stuff, it would be quite a victory in the battle against neural damage caused by xtc, what do you guys think?

Thanks for your comments guys.
 
5-htp is pretty cheap if you know where to look. I've got 1lb of it for bellow $20.
 
^^

you can not get a pound of pure 5-HTP (or anything near pure) for $20

sorry, you've been had

simple understanding of the cost of producing this tell sharply otherwise

you may have a very low standardized extract of Griffonia Simplifolia ....AT BEST
 
we get these tablets in oz come in 2pills per packet I just went and grabbed 1 i have left over they are basically vitamin tabs i will write ingredients down they have on back of pack as best i can on front they are called
Sparkle ,lots of good stuff to replace the bad stuff,puts back what you take out .is all written on front of pack
on back is written
Each tablet contains thiamine hydrochloride(B1)15mg,riboflavine(B2)15mg ,nicotinamide(B3) 50mg , pyndoxine hydrochloride (B6) 25mg , cyanocobalamin (B12) 100mcg , biotin 150mcg , magnesium amino acid chelate 300mg , (equiv.magnesium 60mg) , potassium citrate 44.2mg (equiv.potassium 16mg) , zinc citrate dihydrate 31.15mg (equiv. zinc 10mg) , plusextracts equivalent to dry: silybum marianum fruit ( milk thistle) 500mg , eleutherococus senticosus root (siberian ginseng ) 450mg , panax ginseng root (korean ginseng) 400mg , panax notoginseng root (tienchi ginseng) 150mg , schizandra chinensis fruit 150mg , camellia sinensis leaf (green tea) 100mg
Directions: take no more than 2 a day
think they do as good a job as 5htp
hope this helps a little as to what they mite contain I guess they are probably all similar
 
And ............. the received wisdom seems to be that if you take 5HTP immediately before a roll it will shorten the duration of the experience (in addition to any possible danger of serotonin syndrome).

I once took 50mg 5HTP about 1 hour prior to ingestion and the roll was less intense and definitely shorter. I do think it helps if taken over the next few days following MDMA though - at least it works for me.

E
 
I've experienced w/ both before & after the roll and now I might / might not take any 5-htp prior to rolling but DEFINITELY post-roll. I've found that supplementing w/ a good multi, 500mg-1g of vit. c, 400mg vit. e, 500mg magnesium and of course 100-200mg 5-htp really helps how you feel the day after. I've also been informed that vitamin-e helps convert the 5-htp into seratonin, so i make sure that I have that on hand while taking the 5-htp.

I do not think that this is a placebo effect, I remember trying with and without the supplements and I definitely feel a lot better the following days after rolling than I do without taking them. I actually make sure that I take the supplements and I do not roll unless I have them on hand.
 
Also, the best way to compare it that I've heard is to compare ur brain to a car's gas tank (bare w/ me here).

explanation of metaphor:

1. brain = gas tank
2. seratonin = gas, you need seratonin to be happy, gas to drive
3. while rolling, ur seratonin is depleting, while driving, ur gas is depleteting
4. after rolling, seratonin has significantly diminished, after driving for a while, gas has significantly deminished
5. taking 5htp will help restore lost seratonin, stopping at a gas station to fill ur car w/ gas will help restore gas... obviously

hope my example answered ur questions, or helped anyways - even though i turned it into after instead of before...
 
Last edited:
^ Haha, in some ways right yeah. Continuing to ram the pedal down (eating more MDMA) doesn't help if there's no fuel for the engine to run on (5-HT to release).
 
You must log in or register to reply here.
Top