Tripman
Bluelight Crew
Well guys the month is drawing to a close and it's that time again where we all must vote for our favourite facts!
1. Loulou reed:
Because France is growing poppies massively. They transform it into different opiates (codeine, morphine), and back in 2000(ish), they sold a few kilograms of very pure heroin to the Switzerland heroin programs, but as soon as it was discovered by the media they stopped selling it by fear of french public reaction.
2. nAON:
The Opium Wars were a number of conflicts thought between China and Britain in the mid-19th century. Britain, through the East India Company, was smuggling vast quantities of opium into China, where it was illegal. After the emperor had smugglers arrested and opium stocks destroyed, Britain sent forces in which ravaged China. The result of the war included the opening of chinese ports to trade, and the secession of Hong Kong to Britain.
Source
3. Louis CK:
Avoid taking opioids after a large meal. Opioids disrupt the flow of bile and pancreatic enzymes, making it difficult for the body to digest food. This often results in undigested food traveling through your intestines, making opioid constipation much more problematic than it already is. If you can, wait an hour or two after a large meal to allow your body a chance to release necessary enzymes.
For mild to moderate constipation, a ginger and celery smoothie may be helpful in aiding bowel movements. Celery is a natural laxative and ginger promotes the production of digestive enzymes.
Good luck and always remember to use wisely.
4. Lacster
mu-opiate receptors are presynaptic, and inhibit neurotransmitter release; through this mechanism, they inhibit the release of GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking the dopamine pathways, exogenous opioids causes inappropriate dopamine release, and lead to aberrant synaptic plasticity, which leads to dependency. opioid receptors have various other vital roles in the CNS and PNS however, controlling pain, cardiac, gastric and vascular function as well as possibly panic and satiation, and receptors are found at postsynaptic locations as well as presynaptically.
Source
5. Mugz
After oral administration, tramadol demonstrates 68% bioavailability, with peak serum concentrations reached within 2 hours.
It is a central analgesic with a low affinity for opioid receptors. Its selectivity for mu receptors has recently been demonstrated, and the M1 metabolite of tramadol (ODT), produced by liver O-demethylation, shows a higher affinity for opioid receptors than the parent drug.
That is why ODT actually feels amazing and great and much more like a real opioid than regular tramadol
Source
6. nAON
In October 2002, Chechen rebels took 850 people hostage in a theatre in Moscow. After negotiations failed, Russian special forces pumped an unidentified gas into the ventilation system, killing 39 of the attackers and 129 of the hostages. Though the exact identity of the gas was never revealed, it was (eventually) revealed by the Russian authorities to be a fentanyl derivative.
1. Loulou reed:
Because France is growing poppies massively. They transform it into different opiates (codeine, morphine), and back in 2000(ish), they sold a few kilograms of very pure heroin to the Switzerland heroin programs, but as soon as it was discovered by the media they stopped selling it by fear of french public reaction.
2. nAON:
The Opium Wars were a number of conflicts thought between China and Britain in the mid-19th century. Britain, through the East India Company, was smuggling vast quantities of opium into China, where it was illegal. After the emperor had smugglers arrested and opium stocks destroyed, Britain sent forces in which ravaged China. The result of the war included the opening of chinese ports to trade, and the secession of Hong Kong to Britain.
Source
3. Louis CK:
Avoid taking opioids after a large meal. Opioids disrupt the flow of bile and pancreatic enzymes, making it difficult for the body to digest food. This often results in undigested food traveling through your intestines, making opioid constipation much more problematic than it already is. If you can, wait an hour or two after a large meal to allow your body a chance to release necessary enzymes.
For mild to moderate constipation, a ginger and celery smoothie may be helpful in aiding bowel movements. Celery is a natural laxative and ginger promotes the production of digestive enzymes.
Good luck and always remember to use wisely.
4. Lacster
mu-opiate receptors are presynaptic, and inhibit neurotransmitter release; through this mechanism, they inhibit the release of GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking the dopamine pathways, exogenous opioids causes inappropriate dopamine release, and lead to aberrant synaptic plasticity, which leads to dependency. opioid receptors have various other vital roles in the CNS and PNS however, controlling pain, cardiac, gastric and vascular function as well as possibly panic and satiation, and receptors are found at postsynaptic locations as well as presynaptically.
Source
5. Mugz
After oral administration, tramadol demonstrates 68% bioavailability, with peak serum concentrations reached within 2 hours.
It is a central analgesic with a low affinity for opioid receptors. Its selectivity for mu receptors has recently been demonstrated, and the M1 metabolite of tramadol (ODT), produced by liver O-demethylation, shows a higher affinity for opioid receptors than the parent drug.
That is why ODT actually feels amazing and great and much more like a real opioid than regular tramadol
Source
6. nAON
In October 2002, Chechen rebels took 850 people hostage in a theatre in Moscow. After negotiations failed, Russian special forces pumped an unidentified gas into the ventilation system, killing 39 of the attackers and 129 of the hostages. Though the exact identity of the gas was never revealed, it was (eventually) revealed by the Russian authorities to be a fentanyl derivative.
