My experience with Baclofen for opioid potentiation. To summarize the upcoming story in one ominous sentence. After 60mg Baclofen and 120mg Oxy IR, my wife described me the next morning as an unconscious pile of quivering, twitching, drooling mess. I "slept on the couch". She took comfort in my tortured moans and loud gasps for air as my lungs clearly decided to take several breaks through the night. I was unresponsive to to almost anything. My neighbor was in combat rescue with the USAF for several Middle East tours stretching dessert storm to most recent conflicts in Syria and Afghanistan. He performed a several deep pain stimuli including jaw line pressure points, a vicious sternal rub and placing my legs and holding them in very uncomfortable stress positions. The sternal worked... Had it not, I would be intubated in a coma as I write this.
This is not my first experience with Baclofen. And it truly is the gold stadard for opiate potentiation. If you insist On using it, remember, Baclofen goes from 20mg's and an OC and feelin' fiiiine to a twitching pile of unresponsive drool in a big damn hurry. It has a tight curve. Just like Soma and many other skeletal muscle relaxers. Simply 10mg too much and you're done. I am a very experienced user of all opiates and their potentiators. IMHO- 600mg cimetedine, a benzo... And maybe promethazine are the way to go. Promethazine goes from "super fun" to intense and unpleasant delerient in about half a pill as well. Please respect Baclofen. It's not well documented. There is no antidote. You go to the ER in Bac OD, you get a dick tube. An endotracheal tube. Supportive care. And a bunch of people hoping you pull through. On a side note, and also poorly advertised, Baclofen is a miracle for severe alcoholism... hardened alcoholics regularly post reviews in shock that not every Dr in the US at least, is at least privy to this life saving information.