Baclofen/gabapentinoids and the GHB receptor

[Kdem]

I've been trying to retrieve something but I've been unable to find it.

I recall that someone said that the gabapentinoids (phenibut ?) but not baclofen had affinity for the GHB receptor, but I don't know where, and what exactly was posted. Perhaps someone could clarify.

 

[mike.vick]

Well the ghb receptor IS on the gaba receptor, and gabapentenoids DO NOT bind to the gaba receptor, except very light binding by phenibut- which is the worst one of all the gabapentenoids, IMO.

 

[serotonin2A]

Well the ghb receptor IS on the gaba receptor, and gabapentenoids DO NOT bind to the gaba receptor, except very light binding by phenibut- which is the worst one of all the gabapentenoids, IMO.

There is a specific receptor for GHB that is an entirely different entity than GABA receptors.

https://en.m.wikipedia.org/wiki/GHB_receptor

 

[Nagelfar]

There is a specific receptor for GHB that is an entirely different entity than GABA receptors.

https://en.m.wikipedia.org/wiki/GHB_receptor

Yes sero has it

GABA_B is distinct from it's affinity for the GHB receptor, which was discovered from GHB and thus named. Receptors are named after the discovering compound, like ritalin binds to the cocaine-receptor; which isn't the dopamine receptor, but rather the reuptake ligand site on the DA transporter; complete other side of the synapse from where dopamine binds though dopamine also "binds" to the substrate site on DAT distinct from the receptor; amphetamines are considered to share that same "site", but which isn't the cocaine receptor site but 'overlaps' with it to some degree.

GHB receptor has been found in drugs meant to agonize it without the GABA; and it is not sedating, but with the potent ones, excitotoxic, causing seizures.

 

[Solipsis]

I don't think phenibut or other gabapentinoids bind to the GHB receptor.

Seems like that someone was confused about phenibut binding to GABAb somewhat, which GHB also does.