Alcohol and benzos have harmed me the most in the long term, and opiates in the short term with my oxy addiction a couple years ago.
With that said though, weed has definately caused some negative reactions in me. Cannabis is the ONLY psychedelic drug that i seem to crave ridiculously after smoking it, even though when i'm actually high on cannabis alone i feel that it's 3rd rate in terms of a psychedelic experience. I smoked at least 6 times daily for 7 years, and just the fact that i was having mildly psychedelic experiences throughout the day for that amount of time, gaining nothing positive from it, aside from just being really mellow, says something about my PERSONAL weed consumption.
I also find it annoying that all of my old friends that i used to be able to socialize with intensly in the past are just getting stoned all the time, and over half of them can't even carry on a decent conversation for 5 minutes. Also, i think i recall subdefy saying this in the overrated/underrated drugs thread: Overrated, drug combos. Underrated, psychedelics by themselves.
When i eat mushrooms now, it's usually by myself, because all of the friends that i used to trip with are smoking so much weed that i can't have a decent trip with them, because along with the psychedelia of the mushrooms, most of them are just completely hazed up off weed and don't really give a shit about using psychedelics as tools to delve into themselves, but just a way to get "mad fuckored and see cool visuals". Alright, nothing wrong with that, i do that sometimes too, but when i try to talk about how great tripping alone can be, and all of the amazing experiences i've had, they basically just tell me to stop overanalizing things so much and smoke a bowl. No thanks, i like tripping without smoking tons of weed sometimes, and maybe just coincidentally, i seem to get the most out of tripping when i dont smoke loads of weed with mushrooms, LSD, MDMA, DXM, or insert other powerful psychedelic.
Now, i think weed should be totally legal, actually all drugs i think should be totally legal, but weed definately seemed to keep me from having clear-headed spiritual trips, and just makes me want to use stronger psychedelics as play toys. Just my personality. I still like weed, as i smoke it once a week, sometimes in pretty large amounts, but even though it is a psychedelic, it seems to interfere with potentially mindblowing experiences that i would be able to remember if i didn't smoke pot constantly while tripping. Weed to me is the psychedelic with no personality and a huge mental cloud, making it hard for me to integrate any thoughts during weed alone or tripping along with weed, into my sober conciousness. It's an enhancer and a major clouder at the same time to me, unless i get some good quality sativa-dominant nugs,(which is rare, most of the high quality cannabis around here is indica dominant) but even good heady highs seem to leave me hazy as fuck after they wear off, and as i mentioned before, craving more even though it really wasn't that mindblowing.
Everyone reacts differently to pot, and obviously there are many different strains out there, and while i never get paranoid while stoned,(i did the first time i got high, but never since then have i had any major paranoia/anxiety) i just use it when i want to have purely recreational trips, as it usually just leaves me feeling dumbed down and hungry in the end.
Even more detail; This is what usually happens with me with cannabis alone, especially when i was smoking daily.
1. Smoked the cannabis, mild psychedelic rush, general feelings of pleasure. Colors brighten, mild CEVS, interesting thoughts.
2. Coming down a bit, usually feel like smoking more at this time, usually happens within the hour. I forget all of the interesting thoughts, still feeling stoned, but the psychedelic effects seem to be gone.
3. Hungry as hell, i eat, usually smoke again, repeat steps 1 and 2.
In conclusion, i think pot can be really nice if not abused, but usually just seems to cloud any potentially enlightening experiences i could have without smoking, or mixing with other psychedelics. Weed does definately enhance benzos/opiates/alcohol though, and those aren't things i use for introspection, so i have no problem smoking bud to just boost the pleasure.
In conclusion, after smoking tons of weed, i find it to be more or less purely recreational, which isn't good or bad, but the goofy fun of smoking has left me in some really retarded hazes during heavy use. Pot is nice to me, but not particularly enlightening. All in good fun.