Recruiting [AUS] New Clinical Trial Testing a Treatment to Help Reduce Cannabis Use - Sydney and Melbourne

C

CUD-CUD Study

Greenlighter
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Apr 30, 2024
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👋 Thomas here from the Cannabidiol (CBD) for Cannabis Use Disorder (CUD) Study at the University of Sydney.

Cannabis Use Disorder is long-term, persistent cannabis use despite significant harms related to your use, such as social and financial harms, e.g. spending more time or money on weed than you'd prefer.

I'm excited to 📢 announce 📢 that we are launching our Phase III clinical trial investigating a new treatment to help people aiming to reduce their cannabis use.

🌱 Study details 🌱
  • A world first clinical trial for CUD, and the largest of its kind.
  • A 12-week study involving study medication.
  • 4 x research interviews at a research clinic located at your convenience.
  • Reimbursement provided for your time.
  • Our study is run across 5 sites in NSW and 2 sites in VIC.
  • To learn more, click our Expression of Interest form; you can also contact us:
If you're keen to read more about the ins and outs of the trial, click through to see our recent 🔗 study publication.
Ethics: ETH02467; ANZCTR: 12623000526673

😎 The research team 😎
Check out the following link for more information on the study, as well as cannabis harm reduction advice: CBD for CUD - User News.

I will be checking this thread and responding to any comments, so please post questions you may have :).
 
There has been previous research looking at CBD to assist people with reducing their use and increasing number of weed-free days.

This article goes over the French example where they can buy high CBD low THC flower over the counter: https://pubmed.ncbi.nlm.nih.gov/34615556/ - And this article (again French example) looks at vaped CBD to reduce cannabis use : https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.899221/full

From our study article:
"There is increasing interest in the use of cannabinoid medications to treat CUD. Promising results have emerged in RCTs with delta-9-tetrahydrocannabinol (THC)-based medications (e.g., nabiximols [16], a 1:1 ratio of THC and CBD) and synthetic THC-based medications (e.g., dronabinol, nabilone) [16, 17]. However, many individuals may not be attracted to cannabinoid ‘agonist’ therapy with THC-based medications as they may have intoxicating, psychotogenic, anxiogenic and addictive properties. Thus, there is growing interest in the potential of non-intoxicating cannabinoids, such as CBD, in the treatment of CUD."

This need for a pharmacotherapy treatment for CUD, alongside positive animal studies with CBD for reducing drug self-administration, are the basis behind using CBD for the study.
 
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